[1]国 萍,李 青.ASCUS患者发生宫颈高级别病变高危因素分析[J].医学信息,2018,31(23):96-100.[doi:10.3969/j.issn.1006-1959.2018.23.026]
　GUO Ping,LI Qing.Analysis of High Risk Factors of Cervical Lesions in Patients with ASCUS[J].Journal of Medical Information,2018,31(23):96-100.[doi:10.3969/j.issn.1006-1959.2018.23.026]
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ASCUS患者发生宫颈高级别病变高危因素分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年23期
页码:
96-100
栏目:
论著
出版日期:
2018-12-01

文章信息/Info

Title:
Analysis of High Risk Factors of Cervical Lesions in Patients with ASCUS
文章编号:
1006-1959（2018）23-0096-05
作者:
国 萍; 李 青
安徽医科大学附属安庆医院妇产科，安徽 安庆 246000
Author(s):
GUO Ping; LI Qing
Department of Gynecology and Obstetrics,Anqing Hospital Affiliated to Anhui Medical University,Anqing 246000,Anhui,China
关键词:
非典型鳞状细胞; 宫颈上皮内瘤变; 人乳头瘤状病毒; 危险因素; CINⅡ
Keywords:
Atypical squamous cells; Cervical intraepithelial neoplasia; Human papillomavirus; Risk factors; CINⅡ
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2018.23.026
文献标志码:
A
摘要:
探讨不能明确意义的非典型鳞状细胞患者发生CINⅡ 及其以上宫颈病变的影响因素。方法 通过完善设计的调查量表对我院门诊就诊行宫颈液基细胞学检查（TCT）为ASCUS的236例患者进行回顾性资料收集，同时行人乳头瘤状病毒（HPV）基因型检测，和阴道镜检查+宫颈活检，对相关危险因素进行单因素和多因素分析。结果 236例ASCUS病变中，病理证实CIN共68例（28.81%），其中CINⅡ及以上检出36例，占总病例数的15.25%。236例ASCUS病例中，高危型HPV阳性率为55.51%，高危型HPV阳性及高危型HPV阴性组CINⅡ及以上病变检出率分别为25.19%、2.86%，差异有统计学意义（P＜0.05）。高危型HPV检测CINⅡ及其以上的敏感性达91.67%，阴性预测值达97.14%。单因素分析中年龄、初次性生活年龄、流产次数、HR-HPV与CINⅡ及其以上密切相关。Logistic多因素回归分析的结果表明初次性生活年龄、流产次数、HR-HPV是宫颈CINⅡ及其以上的高危因素。结论 高危型HPV检测是ASCUS患者分流的重要指标，尤其是年龄在30~50岁。初次性生活年龄≤20岁、流产次数＞2次、HR-HPV是ASCUS患者发生宫颈高度病变的独立的高危因素。
Abstract:
Objective To investigate the influencing factors of CINⅡ and above cervical lesions in atypical squamous cell patients without definite significance.Methods A total of 236 patients with cervical liquid-based cytology (TCT) as ASCUS were collected retrospectively by a well-designed survey scale,at the same time, the detection of (HPV) genotype of pedestrian papillomavirus and colposcopy examination+cervical biopsy,the related risk factors were analyzed by univariate and multivariate analysis.Results Of the 236 cases of ASCUS lesions, 68 cases (28.81%) were confirmed by pathology as CIN.36 cases of CINⅡ and above were detected, accounting for 15.25% of the total cases.In 236 cases of ASCUS, the positive rate of high-risk type HPV was 55.51%.The detection rates of CINⅡ and above in high risk HPV positive group and high risk HPV negative group were 25.19%,2.86%, respectively,the difference was statistically significant (P<0.05).The sensitivity of high risk HPV for detecting CINⅡ and above was 91.67% and the negative predictive value was 97.14%.Univariate analysis showed that age, age of first sexual life, number of miscarriages and HR-HPV were closely related to CINⅡ and above.The results of Logistic multivariate regression analysis showed that the age of first sexual life, the number of miscarriages and HR-HPV were high risk factors for cervical CINⅡ and above.Conclusion High-risk HPV is an important indicator of shunt in ASCUS patients, especially in 30~50 years old.The age of first sexual life ≤ 20 years old, and the number of miscarriages more than 2,HR-HPV were independent risk factors for high cervical lesions in patients with ASCUS.

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更新日期/Last Update: 2018-12-17