[1]付云杰.肺癌患者血浆D-二聚体、NSE及CYFRA21-1联合检测的临床价值[J].医学信息,2018,31(23):161-163.[doi:10.3969/j.issn.1006-1959.2018.23.047]
　FU Yun-jie.Clinical Value of the Plasma D-dimer and Serum NSE,CYFRA21-1 Combined Detection in the Diagnosis of Lung Cancer[J].Journal of Medical Information,2018,31(23):161-163.[doi:10.3969/j.issn.1006-1959.2018.23.047]
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肺癌患者血浆D-二聚体、NSE及CYFRA21-1联合检测的临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年23期
页码:
161-163
栏目:
诊疗技术
出版日期:
2018-12-01

文章信息/Info

Title:
Clinical Value of the Plasma D-dimer and Serum NSE,CYFRA21-1 Combined Detection in the Diagnosis of Lung Cancer
文章编号:
1006-1959（2018）23-0161-03
作者:
付云杰
九江市第一人民医院呼吸内科，江西 九江 332000
Author(s):
FU Yun-jie
Department of Respiratory Medicine,Jiujiang First People's Hospital,Jiujiang 332000,Jiangxi,China
关键词:
肺癌; D-二聚体; 神经元特异性烯醇化酶; 细胞角蛋白19片段21-1
Keywords:
Lung cancer; D-dimer; Neuronspecific enolase; Cytokeratin 19 fragment21-1
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2018.23.047
文献标志码:
A
摘要:
探讨血浆D-二聚体和神经元特异性烯醇化酶、细胞角蛋白19片段21-1联合检测在肺癌诊断中的临床价值。方法 选取2016年2月~2017年12月我院收治的130例肺癌患者作为肺癌组，同时选取40例肺部良性肿瘤患者（良性病变组）及40例同期体检健康者（健康对照组）为对照，采用化学发光法检测血清NSE、CYFRA21-1，血浆D-二聚体检测采用免疫比浊法分别检测各组血浆D-D、血清NSE和CYFRA21-1水平，并对结果进行分析。结果 肺癌组血浆D-D、血清NSE和CYFRA21-1水平均高于肺部良性病变组及健康对照组（P＜0.05）；三项指标与肺癌的恶性程度相关，肺癌分期Ⅲ~Ⅳ期患者血浆D-D、血清NSE和CYFRA21-1水平高于Ⅰ~Ⅱ期患者（P＜0.05）；血浆D-D、血清NSE和CYFRA21-1在肺癌中的敏感度分别为68.31%、54.44%及52.22%，其三项联合检测的敏感度为88.89%。结论 肺癌患者血浆D-D、血清NSE和CYFRA21-1水平升高，对肺癌的临床分期具有一定鉴别诊断作用，可以作为肺癌诊断的敏感指标。三项联合检测对肺癌的早期辅助诊断具有重要的临床价值。
Abstract:
Objective To evaluate the plasma D-dimer(D-D) and serum neuronspecific enolase(NSE), Cytokeratin 19 fragment21-1 (CYFRA21-1) combined detection in the diagnosis of lung cancer．Methods 130 cases of lung cancer were selected admitted to our hospital from February 2016 to December 2017 as the research object (lung cancer group), At the same time, 40 patients with benign lung cancer (benign lesion group) and 40 patients (healthy control group) were selected as the control. The levels of D-D,NSE and CYFRA21-1 in all subjects were detected and the results were analyzed. Results Plasma D-D, serum NSE and CYFRA21-1 in the lung cancer group were significantly higher than those in the lung benign lesion group and the healthy control group (P＜0.05).Three indicators were associated with the malignant degree of lung cancer. The levels of plasma D-D,serum NSE and CYFRA21-1 at stage Ⅲ/Ⅳ were higher than those at stageⅠ/Ⅱ(P＜0.05). The sensitivity of plasma D-D,serum NSE and CYFRA21-1 in the diagnosis of lung cancer was 68.31%, 54.44% and 52.22%, but the combined sensitivity was 88.89%.Conclusion The levels of plasma D-D, serum NSE and CYFRA21-1 in lung cancer patients were significantly increased, and the clinical staging of lung cancer had a certain differential diagnosis role, which could be used as a sensitive indicator for the diagnosis of lung cancer. The combined detection of plasma D-D,serum NSE and CYFRA21-1 plays an important role in the diagnosis of lung cancer.

参考文献/References:

[1]Addario BJ.Lung cancer is a global epidemic and requires a global effort[J].Ann Transl Med,2015,3(2):26.
[2]李沫,郑敏玲,许振杰,等.血清NSE、SCC、CYFRA21-1和CEA联合检测对肺癌的诊断价值[J].中国热带医学,2016,16(6):584-587.
[3]方恒忠,陈炯.血清肿瘤标志物在胰腺癌早期诊断中的研究进展[J].国际外科学杂志,2015,42(9):642-645.
[4]白珊珊,何雅军.CA125、CA724、HE4和CEA联合检测在卵巢癌诊断中的应用[J].国际检验医学杂志,2016,37(5):639-641.
[5]王静,张侠.恶性肿瘤患者高凝状态的危险因素、发生机制及实验室检测[J].检验医学与临床,2015,12(15):2284-2287.
[6]郭欣,裴毅.老年结肠癌患者D-二聚体与肿瘤进展的相关性研究[J].中国药物与临床,2016,16(6):878-879.
[7]张呈球,施武辉,夏小明.纤维蛋白原和D-二聚体联合检测在肝癌中的临床意义[J].实验与检验医学,2011,29(2):164.
[8]赵如森,孙明,王永涛,等.凝血状态对肺癌的诊断及化疗效果的评估价值[J].实用癌症杂志,2016,31(11):1910-1911.
[9]高娟,任晓兵,井晓.神经元特异性烯醇化酶(NSE)在肺癌患者中的分层分析及临床意义[J].现代肿瘤医学,2017,25(20):3261-3265.
[10]余建洪,朱晓丽.ROC曲线评价4项指标对肺癌的鉴别诊断价值[J].检验医学与临床,2017,14(3):361-363.
[11]张萍,王红义,杨迎桂,等.血清CEA、ProGRP、NSE和CYFRA21-1联合检测在肺癌诊断中的应用研究[J].现代检验医学杂志,2016,31(2):56-59.
[12]沈娟,周芸,夏守慧,等.血清肿瘤标志物联合检测在非小细胞肺癌诊断中的价值[J].中国实用医药,2017,12(5):1-3.

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更新日期/Last Update: 2018-12-17