[1]李志俊,王 利,王 浩.姜黄素改善糖尿病肾病的作用机制研究[J].医学信息,2018,31(24):35-38.[doi:10.3969/j.issn.1006-1959.2018.24.010]
 LI Zhi-jun,WANG Li,WANG Hao.Study on the Mechanism of Curcumin in Improving Diabetic Nephropathy[J].Journal of Medical Information,2018,31(24):35-38.[doi:10.3969/j.issn.1006-1959.2018.24.010]
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姜黄素改善糖尿病肾病的作用机制研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年24期
页码:
35-38
栏目:
综述
出版日期:
2018-12-15

文章信息/Info

Title:
Study on the Mechanism of Curcumin in Improving Diabetic Nephropathy
文章编号:
1006-1959(2018)24-0035-04
作者:
李志俊王 利王 浩
上海中医药大学附属普陀医院肾内科,上海 200062
Author(s):
LI Zhi-junWANG LiWANG Hao
Department of Nephrology,Putuo Hospital,Shanghai University of Traditional Chinese Medicine, Shanghai 200062,China
关键词:
姜黄素糖尿病肾病氧化应激纤维化
Keywords:
CurcuminDiabetic nephropathyOxidative stressFibrosis
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2018.24.010
文献标志码:
A
摘要:
糖尿病肾病(DN)是糖尿病的严重并发症,表现为尿蛋白水平升高,肾小球滤过率降低(GFR)和最终肾功能不全。DN是全球范围内终末期肾病发生的主要原因,严重影响患者的生活质量和预后。现代医学治疗手段不能有良好的治疗效果,中医药在治疗本病方面取得了良好的成就。姜黄素是一种从姜黄根中分离出来的黄咖喱色素,已有研究表明其能改善DN的进展,然而姜黄素在DN的作用机制尚不明确,本文从姜黄素改善DN的氧化应激、炎症、肾脏纤维化、细胞凋亡等作用机制方面做一综述。
Abstract:
Diabetic nephropathy (DN) is a serious complication of diabetes characterized by elevated levels of urinary protein, decreased glomerular filtration rate (GFR), and eventual renal insufficiency. DN is the leading cause of end-stage renal disease worldwide, which seriously affects patients' quality of life and prognosis. Modern medical treatments can not have a good therapeutic effect, and Chinese medicine has achieved good results in the treatment of this disease. Curcumin is a yellow curry pigment isolated from turmeric root. It has been shown to improve the progress of DN. However, the mechanism of action of curcumin in DN is still unclear. This article improves the oxidative stress of DN from curcumin. The mechanism of action such as inflammation, renal fibrosis and apoptosis is reviewed.

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更新日期/Last Update: 2019-01-09