参考文献/References:
[1]Costa-Mattioli M,Monteggia LM.mTOR complexes in neurodevelopmental and neuropsychiatric disorders[J].Nat Neurosci,2013,16(11):1537-1543.
[2]Martínez de Morentin PB,Martinez-Sanchez N,Roa J,et al.Hypothalamic mTOR:the rookie energy sensor[J].Curr Mol Med,2014,14(1):3-21.
[3]Laplante M,Sabatini DM.Regulation of mTORC1 and its impact on gene expression at a glance[J].J Cell Sci,2013,126(Pt 8):1713-1719.
[4]Laplante M,Sabatini DM.mTOR signaling in growth control and disease[J].Cell,149(2):274-293.
[5]Dennis PB,Jaeschke A,Saitoh M,et al.Mammalian TOR:a homeostatic ATP sensor[J].Science,2001,294(5544):1102-1105.
[6]Sengupta S,Peterson TR,Sabatini DM.Regulation of the mTOR complex 1 pathway by nutrients,growth factors,and stress[J].Mol Cell,2010,40(2):310-322.
[7]Dagon Y,Hur E,Zheng B.p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake[J].Cell Metab,2012,16(1):104-112.
[8]Bauchart-Thevret C,Cui L,Wu G,et al.Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide[J].Am J Physiol Endocrinol Metab,2010,299(6):E899-E909.
[9]Jenna L,Jewell,Kun-Liang Guan.Nutrient signaling to mTOR and cell growth[J].Trends Biochem Sci,2013,38(5):233-242.
[10]Yoon MS,Du G,Backer JM,et al.Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway[J].J Cell Biol,2011,195(3):435-447.
[11]Düvel K,Yecies JL,Menon S,et al.2010.Activation of ametabolic gene regulatory network downstream of mTOR complex1[J].Mol Cell,2010,39(2):171-183.
[12]Hagiwara A,Cornu M,Cybulski N,et al.Hepatic mTORC2 activates glycolysis and lipogenesis through Akt,glucokinase,and SREBP1c[J].Cell Metab,2012,15(5):725-738.
[13]Meng ZX,Li S,Wang L,et al.Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation[J].Nat Med,2013,19(5):640-645.
[14]Pulakat L,DeMarco VG,Ardhanari S,et al.Adaptive mechanisms to compensate for overnutrition-inducedcardiovascular abnormalities[J].Am J Physiol Regul Integr Comp Physiol,2011 ,301(4):R885-R895.
[15]Deldicque L,Cani PD,Philp A,et al.The unfolded protein response is activated in skeletal muscle by high-fat feeding:potential role in the down-regulation of protein synthesis[J].Am J Physiol Endocrinol Metab,2010,299(5):E695-E705.
[16]Chakrabarti P,English T,Shi J,et al.Mammalian target of rapamycin complex 1 suppresses lipolysis,stimulates lipogenesis, and promotes fat storage[J].Diabetes,2010,59(4):775-781.
[17]Soliman GA,Acosta-Jaquez HA,Fingar DC.mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes[J].Lipids,2010,45(12):1089-1100.
[18]Varela L,Martínez-Sánchez N,Gallego R,et al.Hypothalamic mTOR pathway mediates thyroid hormone-inducedhyperphagia in hyperthyroidism[J].J Pathol,2012,227(2):209-222.
[19]Villanueva EC,Münzberg H,Cota D,et al.Complex regulation of mammalian target of rapamycin complex 1in the basomedial hypothalamus by leptin and nutritional status[J].Endocrinology,2009,150(10):4541-4551.
[20] Wan M,Leavens KF,Saleh D,et al.Postprandial hepatic lipid metabolism requires signaling through Akt2independent of the transcription factors FoxA2,FoxO1,and SREBP1c[J].Cell Metab,2011,14(4):516-527.