[1]曹岚,侯瑞田,王福慧,等.Lp-PLA2血小板相关因子与2型糖尿病合并高血压病的 相关性研究[J].医学信息,2018,31(05):3-6，10.[doi:10.3969/j.issn.1006-1959.2018.05.002]
　CAO Lan,HOU Rui-tian,WANG Fu-hui,et al.Study on the Correlation between Lp-PLA2 Platelet-associated Factors and Type 2 Diabetes Mellitus Complicated with Hypertension[J].Journal of Medical Information,2018,31(05):3-6，10.[doi:10.3969/j.issn.1006-1959.2018.05.002]
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Lp-PLA2血小板相关因子与2型糖尿病合并高血压病的 相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年05期
页码:
3-6，10
栏目:
出版日期:
2018-03-01

文章信息/Info

Title:
Study on the Correlation between Lp-PLA2 Platelet-associated Factors and Type 2 Diabetes Mellitus Complicated with Hypertension
文章编号:
1006-1959（2018）05-0003-05
作者:
曹岚1; 侯瑞田2; 王福慧1; 葛晓春2; 何建秋2; 甄江伟1; 金凤表2
1.承德医学院，河北 承德 067000；2.承德医学院附属医院内分泌科，河北 承德 067000
Author(s):
CAO Lan1; HOU Rui-tian2; WANG Fu-hui1; GE Xiao-chun2; HE Jian-qiu2; ZHEN Jiang-wei1;  JIN Feng-biao2
1.Chengde Medical College,Chengde 067000,Hebei,China; 2.Department of Endocrinology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China
关键词:
2型糖尿病; 高血压病; Lp-PLA2; 血小板相关因子
Keywords:
Key words：Type 2 diabetes mellitus; Hypertension; Lp-PLA2; Platelet-associated factors
分类号:
R587.1；R544.1
DOI:
10.3969/j.issn.1006-1959.2018.05.002
文献标志码:
A
摘要:
目的 探讨脂蛋白相关性磷脂酶A2（Lp-PLA2）、血小板相关因子与2型糖尿病合并高血压病患者的相关性。方法 连续入选我院2型糖尿病患者共102例，分为2型糖尿病合并高血压病组（n=50）、单纯2型糖尿病组（n=52），以及同期住院的单纯高血压病组（n=30）、体检健康对照组（n=30）。记录四组患者一般资料、生化指标及血小板相关因子--血小板计数（PLT）、血小板分布宽度（PDW）、平均血小板容积（MPV）及大血小板比率（P-LCR）水平，并测定Lp-PLA2水平。结果 四组间性别、年龄、ALT、AST、Scr、BUN、TCH比较，差异无统计学意义（P＞0.05）。2型糖尿病合并高血压病患者的Lp-PLA2及PDW、MPV、P-LCR水平较单纯2型糖尿病患者、单纯高血压病组及健康对照组升高，差异有统计学意义（P＜0.05）；PLT较单纯2型糖尿病组、单纯高血压病组及健康对照组降低，差异有统计学意义（P＜0.05）。Lp-PLA2、PDW与收缩压（SBP）成正相关（P＜0.05），Lp-PLA2、PDW、MPW、P-LCT与糖化血红蛋白（HbA1c）成正相关（P＜0.05）。结论 Lp-PLA2、血小板相关因子可评估2型糖尿病患者血管内皮功能状态，合并高血压病的2型糖尿病患者血管内皮功能障碍更加严重，且该严重程度与血压、血糖控制不佳的程度有关。
Abstract:
Abstract：Objective To investigate the relationship between lipoprotein associated phospholipase A2（Lp-PLA2）,platelet related factors and type 2 diabetes mellitus complicated with hypertension.Methods 102 patients with type 2 diabetes mellitus were enrolled in our hospital.The patients were divided into two groups:type 2 diabetes mellitus complicated with hypertension group(n=50),type 2 diabetes group(n=52),hypertension group(n=30)and healthy control group(n=30).The general data, biochemical parameters and platelet related factor-platelet count(PLT),platelet distribution width(PDW),mean platelet volume(MPV)and large platelet ratio(P-LCR)were recorded in the four groups,and the level of Lp-PLA2 was measured.Results There was no significant difference in the age,sex,ALT,AST,Scr,BUN,TCH among the four groups(P>0.05).Type 2 diabetes mellitus and hypertension in patients with Lp-PLA2 and PDW, MPV and P-LCR levels higher than patients with type 2 diabetes mellitus,hypertension group and healthy control group increased,the difference was statistically significant(P<0.05);PLT compared with type 2 diabetes group and simple hypertension group and healthy control group decreased,with statistical significance the difference(P<0.05).Lp-PLA2 and PDW were positively correlated with systolic blood pressure(SBP)(P<0.05),and Lp-PLA2,PDW,MPW and P-LCT were positively correlated with glycosylated hemoglobin(HbA1c) (P<0.05).Conclusion Lp-PLA2 and platelet related factors can evaluate endothelial function in patients with type 2 diabetes mellitus, and endothelial dysfunction is more severe in type 2 diabetic patients with hypertension,and the severity is related to the degree of blood pressure and blood sugar control.

参考文献/References:

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更新日期/Last Update: 2018-03-01