[1]雷少晖,张永海.脑氧代谢的影像学测定方法研究[J].医学信息,2018,31(05):38-41.[doi:10.3969/j.issn.1006-1959.2018.05.015]
　LEI Shao-hui,ZHANG Yong-hai.Imaging Study of Brain Oxygen Metabolism[J].Journal of Medical Information,2018,31(05):38-41.[doi:10.3969/j.issn.1006-1959.2018.05.015]
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脑氧代谢的影像学测定方法研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年05期
页码:
38-41
栏目:
综述
出版日期:
2018-03-01

文章信息/Info

Title:
Imaging Study of Brain Oxygen Metabolism
文章编号:
1006-1959（2018）05-0038-04
作者:
雷少晖1; 2; 张永海2
1.青海大学，青海 西宁 810000；2.青海省人民医院，青海 西宁 810000
Author(s):
LEI Shao-hui1; 2; ZHANG Yong-hai2
1.Qinghai University,Xining 810000,Qinghai,China;2.Qinghai Provincial People's Hospital,Xining 810000,Qinghai,China
关键词:
脑血流量; 氧摄取率; 脑氧代谢率; 磁共振成像; 动脉自旋标记
Keywords:
Key words：Cerebral blood flow; Oxygen uptake rate; Cerebral oxygen metabolism rate; Magnetic resonance imaging; Arterial spin labeling
分类号:
R774
DOI:
10.3969/j.issn.1006-1959.2018.05.015
文献标志码:
A
摘要:
随着年龄的不断增长，脑血管疾病的发生率越来越高，对于脑血管疾病的血运动力学的研究越来越重要，能更好的认识脑血管疾病，从而能更早的发现、治疗及预防脑血管疾病。判断血液动力学的参数有脑血流量﹑灌注压、颅内压、氧摄取率、脑脊液和脑氧代谢率，正常状态下脑摄取与脑利用之间处于动态的平衡，当出现脑血管疾病时各参数之间将会出现变化，对于参数的研究能敏感的反应脑氧代谢的差异，从而更好的指导临床，更早的对疾病进行治疗，延缓恶化，同时为临床科研项目提供更加重要的线索。
Abstract:
Abstract：With the increasing of age,the incidence of cerebrovascular diseases is increasing.It is more and more important to study the blood dynamics of cerebrovascular diseases,which can better understand cerebrovascular diseases,so that we can discover,treat and prevent cerebrovascular diseases earlier.The hemodynamic parameters of cerebral hemodynamics include cerebral blood flow, perfusion pressure,intracranial pressure,oxygen uptake rate,cerebrospinal fluid,and cerebral oxygen metabolism rate.Under normal conditions,there is a dynamic balance between brain uptake and brain utilization.When cerebrovascular disease occurs changes will occur between the parameters.The study of parameters can be sensitive to the differences in cerebral oxygen metabolism,so as to better guide the clinical,early treatment of the disease,delay deterioration,and provide more important clinical research projects clue.

参考文献/References:

[1]Singhal AB,Lo EH.Advances in emerging nondrug therapies for acute stroke 2007[J].Stroke,2008,39(2):289-291. [2]Hackett PH,Roach RC.High altitude cerebral edema[J].High Alt Med Biol,2004,5(2):136-146. [3]Jordan JD,Powers WJ.Cerebral auto regulation and acute ischemic stroke[J].Am J Hy pertens,2012,25(9):946-950. [4]Lin W,Celik A,Derdeyn C,et al.Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion:a PET and MR study[J].J Magn Reson Imaging,2001,14(6):659-667. [5]Bremmer JP,van Berckel BN,Persoon S,et al.Day-to-day test-re-test variability of CBF,CMRO2,and OEF measurements using dynamic 15O PET studies[J].Mol Imaging Biol,2011,13(4):759-768. [6]CUI Can,MA Yun-chuan.Methods and Significance of Cerebral Vascular Reserve Function [J].Journal of Clinical and Experimental Medicine,2015,14(02):160-164. [7]崔璨,马云川.脑血管储备功能的检测方法及意义[J].临床和实验医学杂志,2015,14(02):160-164. [8]Zhou X.Chinese Journal of imaging medical imaging nuclear medicine[M].Beijing:People's Health Publishing House,2003. [9]周前.中国影像医学影像核医学卷[M].北京:人民卫生出版社,2003. [10]Konstas AA,Goldmakher GV,Lee TY,et al.Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke,part 2:technical implementations[J].Am J Neuroradiol,2009,30(5):885-892. [11]Hoeffner EG,Case I,Jain R,et al.Cerebral perfusion CT: technique and clinical applications[J].Radiology,2004,231(3):632-644. [12]Kim HJ,Kim TW,Ryu SY,et al.Acetazolamide-challenged perfusion magnetic resonance imaging for assessment of cerebrovascular reserve capacity in patients with symptomatic middle cerebral artery stenosis:comparison withtechnetium-99m-hexamethylpropyleneamine oxime single-photon emission computed tomography[J].Clin Imaging,2011,35(6):413-420. [13]Ma J,Mehrkens JH,Holtmannspoetter M,et al.Perfusion MRI before and after acetazolamide administration for assessment of cerebrovascular reserve capacity in patients with symptomatic internal carotid artery(ICA)occlusion:comparison with 99mTc-ECD SPECT[J].Neuroradiology,2007,49(4):317-326. [14]Duyu JH,Mone CW,Van GH,et al.Inflow versus deoxy- Hemog-tobin effects in BOLD functional magotic resonance Imaging using gradient echoes at 1.5T NMR[J].Bio Med,1994,7(2):83-95.[15]Spano VR,Mandell DM,Poublanc J,et al.CO2 blood oxygen level-dependent MR mapping of cerebrovascular reserve in a clinical population:safety，tolerability，and technical feasibility [J].Radiology,2013,266(2):592-598. [16]张春雨,呼日乐．急性脑血管病脑缺血半暗带的研究进展[J]．实用医学影像杂志,2004,5(3):173-174． [17]Detre JA,Leigh JS,Williams DS,et al.Perfusion imaging[J]．Magn Reson Med,1992,23(1):37-45． [18]Wu WC,Fernández-Seara M,Detre JA,et al.A theoretical and experimental investigation of the tagging efficiency of pseudo continuous arterial spin labeling[J].Magn Reson Med,2007,58(5):1020-1027. [19]Wong EC,Buxton RB,Frank LR.A theoretical and experimental comparison of continuous and pulsed arterial spin labeling techniques for quantitative perfusion imaging[J].Magnetic resonance in medicine,1998,40(3):348. [20]Ioannis K,Edelman RR.Carotid MR angiography using pulsed continuous arterial spin labeling[J].Journal of Cardiovascular Magnetic Resonance,2011,13(1):1-2.

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更新日期/Last Update: 2018-03-01