[1]赵俊芝,赵永强,梁 曼.甲泼尼龙联合阿奇霉素治疗难治性支原体肺炎患儿的 临床效果分析[J].医学信息,2018,31(07):131-133.[doi:10.3969/j.issn.1006-1959.2018.07.044]
　ZHAO Jun-zhi,ZHAO Yong-qiang,LIANG Man.Analysis of the Clinical Effect of Methylprednisolone Combined with Azithromycin in Treatment of Children with Refractory Mycoplasma Pneumonia[J].Journal of Medical Information,2018,31(07):131-133.[doi:10.3969/j.issn.1006-1959.2018.07.044]
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甲泼尼龙联合阿奇霉素治疗难治性支原体肺炎患儿的 临床效果分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年07期
页码:
131-133
栏目:
药物与临床
出版日期:
2018-04-01

文章信息/Info

Title:
Analysis of the Clinical Effect of Methylprednisolone Combined with Azithromycin in Treatment of Children with Refractory Mycoplasma Pneumonia
文章编号:
1006-1959（2018）07-0131-03
作者:
赵俊芝1; 赵永强2; 梁 曼1
1.抚顺市抚顺县人民医院儿科，辽宁 抚顺 113006； 2.抚顺市矿业集团总医院儿科，辽宁 抚顺 113000
Author(s):
ZHAO Jun-zhi1; ZHAO Yong-qiang2; LIANG Man1
1.Department of Pediatrics,Fushun County People's Hospital,Fushun 113006,Liaoning,China; 2.Department of Pediatrics,General Hospital of Fushun Mining Industry Group,Fushun 113000,Liaoning,China
关键词:
难治性支原体肺炎; 甲泼尼龙; 阿奇霉素
Keywords:
Key words：Refractory mycoplasma pneumonia; Methylprednisolone; Azithromycin
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2018.07.044
文献标志码:
A
摘要:
目的 分析难治性支原体肺炎患儿应用甲泼尼龙联合阿奇霉素方案的效果。方法 择取2016年7月~2017年9月我院收治的86例RMPP者为研究对象，随机分为对照组和观察组，每组43例。对照组应用阿奇霉素方案，观察组在对照组基础上使用甲泼尼龙，观察两组患者体温恢复时间、治疗时间、治疗前后C反应蛋白水平，治疗效果以及治疗过程中不良反应发生情况。结果 观察组治疗时间、体温恢复时间短于对照组，差异具有统计学意义（P＜0.05）。治疗前，两组患儿C反应蛋白差异无统计学意义（P＞0.05）；治疗后，两组患儿C反应蛋白均有一定改善，观察组优于对照组，差异具有统计学意义（P＜0.05）。观察组治疗有效率为95.35%，高于对照组的72.09%，差异具有统计学意义（P＜0.05）。两组不良反应发生率相比，差异无统计学意义（P＞0.05）。结论 对于小儿RMPP患者使用应用甲泼尼龙联合阿奇霉素方案治疗，临床效果确切，不良反应少，有效率高，有助于疾病转归，值得进一步推广。
Abstract:
Abstract：Objective To analyze the effect of methylprednisolone combined with azithromycin in children with refractory mycoplasma pneumonia.Methods 86 patients with RMPP from July 2016 to September 2017 were randomly divided into control group(n=43)and observation group(n = 43).Azithromycin regimen was used in the control group,and methylprednisolone was used in the observation group on the basis of the control group.The temperature recovery time,treatment time,C-reactive protein level before and after treatment were observed in the two groups.The effect of treatment and the occurrence of adverse reactions in the course of treatment.Results The treatment time and the recovery time of body temperature in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in C-reactive protein between the two groups(P>0.05),but after treatment,the C-reactive protein in both groups was improved to some extent,and the observation group was superior to the control group,the difference was statistically significant(P<0.05).The effective rate of treatment in the observation group was 95.35%,which was higher than that of the control group 72.09%,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion For children RMPP patients treated with methylprednisolone combined with azithromycin treatment,clinical efficacy, adverse reactions,high effective rate,contribute to the prognosis of the disease,it is worthy of further promotion.

参考文献/References:

[1]任明星,薛国昌,沈琳娜,等.甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎的疗效与安全性分析[J].中国全科医学,2015,18(05):588-591. [2]矫云.甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎的疗效观察[J].中国医药指南,2016,14(29):76-77. [3]刘开云.分析甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎的疗效与安全性[J].中国实用医药,2016,11(21):151-152. [4]王丹.甲泼尼龙联合阿奇霉素对小儿难治性支原体肺炎的治疗效果观察[J].中国卫生标准管理,2016,7(18):104-105. [5]杨春艳,王云.甲泼尼龙联合阿奇霉素治疗小儿支原体肺炎的临床疗效[J].中外医疗,2015,34(36):121-123. [6]王丽君.甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎的疗效与安全性研究[J].临床医学,2016,36(01):105-107. [7]范徐威.甲泼尼龙联合阿奇霉素治疗小儿难治性支原体肺炎(RMPP)的疗效与安全性[J].生物医学工程学进展,2015,36(04):246-248. [8]张超雁,高立品.甲泼尼龙联合阿奇霉素在小儿难治性支原体肺炎治疗中的应用效果观察[J].中国实用医药,2015,10(36):133-134. [9]张萍.阿奇霉素与甲泼尼龙联合治疗小儿难治性支原体肺炎的临床疗效分析[J].中国继续医学教育,2015,7(24):156-157. [10]李华浚,陈啸洪,章杭湖,等.阿奇霉素联合甲泼尼龙治疗肺炎支原体肺炎患儿的临床研究[J].中国临床药理学杂志,2015,31(10):771-773.

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更新日期/Last Update: 2018-04-01