[1]谢 琴.肾小球C4d沉积在慢性肾病早期诊断及预后的价值分析[J].医学信息,2018,31(08):81-83.[doi:10.3969/j.issn.1006-1959.2018.08.025]
　XIE Qin.Value of Glomerular C4d Deposition in Early Diagnosis and Prognosis of Chronic Kidney Disease[J].Journal of Medical Information,2018,31(08):81-83.[doi:10.3969/j.issn.1006-1959.2018.08.025]
点击复制

肾小球C4d沉积在慢性肾病早期诊断及预后的价值分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年08期
页码:
81-83
栏目:
论著
出版日期:
2018-04-15

文章信息/Info

Title:
Value of Glomerular C4d Deposition in Early Diagnosis and Prognosis of Chronic Kidney Disease
文章编号:
1006-1959（2018）08-0081-03
作者:
谢 琴
四川省宣汉县人民医院肾内科，四川 宣汉 635150
Author(s):
XIE Qin
Department of Nephrology,Xuanhan County People's Hospital,Xuanhan 635150,Sichuan,China
关键词:
慢性肾脏病; 诊断; 肾小球血管袢; C4d
Keywords:
Key words：Chronic kidney disease; Diagnosis; Glomerular vasospasm; C4d
分类号:
R446.1；R692
DOI:
10.3969/j.issn.1006-1959.2018.08.025
文献标志码:
A
摘要:
目的 分析肾小球沉积C4d在慢性肾病中的价值,为临床提供可靠依据。方法 本次研究选自2014年1月～2017年1月医院肾内科肾脏病理检验患者194例，其中慢性肾脏病86例，急性肾损伤性疾病108例，均采用免疫组织化学检验肾小球C4d，进行沉积分型，慢性肾脏病对象划分为有效组（8周内随访蛋白尿得到控制）、对照组。对比慢性肾脏病、急性肾损伤患者肾小球C4d沉积情况，分析慢性肾脏病在C4d沉积表达中是否存在独立作用。分析肾小球C4d沉积是否在慢性病治疗中起到作用。结果 慢性肾脏病肾小球C4d阳性率、毛细血管袢区沉积伴系膜区沉积比重高于急性肾脏病对象，差异有统计学意义（P＜0.05）。肾小球毛细血管袢区C4d沉积成为慢性肾脏病疾病未获得控制的独立影响因素（P＜0.05）。结论 肾小球C4d沉积在早期诊断及判断预后具有价值，肾小球C4d毛细血管袢区沉积伴系膜区沉积慢性肾脏病风险较高，同时在疗效预测上有更高的价值。
Abstract:
Abstract：Objective To analyze the value of glomerular deposition C4d in chronic nephropathy.Methods From January 2014 to January 2017,194 cases of renal pathology were selected,including 86 cases of chronic kidney disease and 108 cases of acute renal injury disease.Glomerular C4d was detected by immunohistochemistry to classify sediments.Subjects with chronic kidney disease were divided into effective groups(control of proteinuria within 8 weeks)and controls.To compare the glomerular C4d deposition in patients with chronic kidney disease and acute kidney injury,and to analyze the independent role of chronic kidney disease in the expression of C4d deposits.Analysis of glomerular C4d deposition plays a role in the treatment of chronic diseases.Results The positive rate of glomerular C4d in chronic kidney disease,deposition in the capillary region,and deposition in the mesangial area were higher than those in acute kidney disease,and the difference was statistically significant(P<0.05).The deposition of C4d in the glomerular capillary loop area was an independent factor that did not control chronic kidney disease(P<0.05).Conclusion The glomerular C4d deposition is valuable in early diagnosis and prognosis.Glomerular C4d in the capillaries of the glomerulus is associated with a higher risk of deposition of chronic kidney disease in the mesangial area,and has a higher value in predicting the efficacy.

参考文献/References:

[1]刘林林,刘楠,王娟,等.肾小球C4d沉积为IgA肾病的预后因子[J].中国医科大学学报,2017,46(01):23-27.
[2]Yao B,Fang H,Xu W,et al.Dietary fiber intake and risk of type 2 diabetes:a dose-response analysis of prospective studies[J].European Journal of Epidemiology,2014,29(2):79.
[3]Zhang L,Zuo L.Current burden of end-stage kidney disease and its future trend in China[J].Clinical Nephrology,2016,86(13):27.
[4]陈灏珠,林果为,王吉耀,等.实用内科学[M].人民卫生出版社,2013:421-422.
[5]邹万忠.肾活检病理学[M].北京:北京大学医学出版社,2006:58-67.
[6]孟凡茹,薛玲,王秀丽,等.紫癜性肾炎患儿外周血白三烯B4水平和CD4~+CD25~+调节性T细胞表达[J].临床输血与检验,2011,13(02):108-110.
[9]Sahin OZ,Yavas H,Tasl F,et al.Prognostic value of glomerular C4d staining in patients with IgA nephritis[J].Int Clin Exp Pathol,2014,7(6):3299-3304.
[10]王丽芳,严静霞,孟凡茹,等.儿童慢性肾小球肾炎血清同型半胱氨酸与尿素氮水平的相关性[J].临床输血与检验,2013,15(04):382-383.

相似文献/References:

[1]韩 梅,吴 寒.我国弓形虫病研究进展[J].医学信息,2018,31(02):33.[doi:10.3969/j.issn.1006-1959.2018.02.012]
　HAN Mei,WU Han.Research Advances on Toxoplasmosis in China[J].Journal of Medical Information,2018,31(08):33.[doi:10.3969/j.issn.1006-1959.2018.02.012]
[2]王艳妮,杨静秀.宫颈上皮内瘤变病因及诊断的相关研究进展[J].医学信息,2018,31(02):46.[doi:10.3969/j.issn.1006-1959.2018.02.016]
　WANG Yan-ni,YANG Jing-xiu.Research Progress on the Causes and Diagnosis of Cervical Intraepithelial Tumor[J].Journal of Medical Information,2018,31(08):46.[doi:10.3969/j.issn.1006-1959.2018.02.016]
[3]高艳飞.降钙素原对新生儿感染性肺炎的早期诊断价值研究[J].医学信息,2018,31(03):154.[doi:10.3969/j.issn.1006-1959.2018.03.056]
　GAO Yan-fei.Study on the Value of Procalcitonin in the Early Diagnosis of Neonatal Infectious Pneumonia[J].Journal of Medical Information,2018,31(08):154.[doi:10.3969/j.issn.1006-1959.2018.03.056]
[4]罗 友,覃开凤,王小红.小颌畸形的产前超声诊断评价分析[J].医学信息,2018,31(04):160.[doi:10.3969/j.issn.1006-1959.2018.04.060]
　LUO You,QIN Kai-feng,WANG Xiao-hong.Evaluation of Prenatal Ultrasound Diagnosis of Maxillary Malformation[J].Journal of Medical Information,2018,31(08):160.[doi:10.3969/j.issn.1006-1959.2018.04.060]
[5]姚玉琳,王小红,覃开凤.大动脉转位的产前超声诊断评价[J].医学信息,2018,31(05):153.[doi:10.3969/j.issn.1006-1959.2018.05.055]
　YAO Yu-lin,WANG Xiao-hong,QIN Kai-feng.Prenatal Ultrasound Diagnosis of Transposition of Great Arteries[J].Journal of Medical Information,2018,31(08):153.[doi:10.3969/j.issn.1006-1959.2018.05.055]
[6]鲁秋彤.经阴道彩色多普勒超声在诊断剖宫产子宫疤痕妊娠中的 价值研究[J].医学信息,2018,31(05):160.[doi:10.3969/j.issn.1006-1959.2018.05.058]
　LU Qiu-tong.The Value of Transvaginal Color Doppler Ultrasound in the Diagnosis of Cesarean Scar Pregnancy[J].Journal of Medical Information,2018,31(08):160.[doi:10.3969/j.issn.1006-1959.2018.05.058]
[7]王秀峰.子宫颈上皮内瘤变的临床诊断治疗相关进展[J].医学信息,2018,31(06):55.[doi:10.3969/j.issn.1006-1959.2018.06.018]
　WANG Xiu-feng.Progress in Clinical Diagnosis and Treatment of Cervical Intraepithelial Neoplasia[J].Journal of Medical Information,2018,31(08):55.[doi:10.3969/j.issn.1006-1959.2018.06.018]
[8]刘爱君.糖化血红蛋白测定在糖尿病诊断中的应用价值分析[J].医学信息,2018,31(08):161.[doi:10.3969/j.issn.1006-1959.2018.08.057]
　LIU Ai-jun.Analysis of the Value of Determination of Glycosylated Hemoglobin in the Diagnosis of Diabetes Mellitus[J].Journal of Medical Information,2018,31(08):161.[doi:10.3969/j.issn.1006-1959.2018.08.057]
[9]刘治利,葛明建.肺部磨玻璃结节的CT特征与治疗策略进展[J].医学信息,2018,31(11):49.[doi:10.3969/j.issn.1006-1959.2018.11.016]
　LIU Zhi-li,GE Ming-jian.Advances in CT Features and Treatment Strategies of Pulmonary Ground-glass Nodule[J].Journal of Medical Information,2018,31(08):49.[doi:10.3969/j.issn.1006-1959.2018.11.016]
[10]黄 韬.藏毛窦疾病治疗分析[J].医学信息,2018,31(11):187.[doi:10.3969/j.issn.1006-1959.2018.11.063]
　HUANG Tao.Treatment of Pilonidal Sinus Disease[J].Journal of Medical Information,2018,31(08):187.[doi:10.3969/j.issn.1006-1959.2018.11.063]

更新日期/Last Update: 2018-04-15