[1]刘 云,于洪波.乌司他丁与生长抑素治疗重症急性胰腺炎临床疗效观察[J].医学信息,2019,32(01):160-161.[doi:10.3969/j.issn.1006-1959.2019.01.050]
　LIU Yun,YU Hong-bo.Clinical Efficacy of Ulinastatin and Somatostatin in the Treatment of Severe Acute Pancreatitis[J].Journal of Medical Information,2019,32(01):160-161.[doi:10.3969/j.issn.1006-1959.2019.01.050]
点击复制

乌司他丁与生长抑素治疗重症急性胰腺炎临床疗效观察()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年01期
页码:
160-161
栏目:
药物与临床
出版日期:
2019-01-01

文章信息/Info

Title:
Clinical Efficacy of Ulinastatin and Somatostatin in the Treatment of Severe Acute Pancreatitis
文章编号:
1006-1959（2019）01-0160-02
作者:
刘 云; 于洪波
大连九洲世纪医院消化内科，辽宁 大连 116400
Author(s):
LIU Yun; YU Hong-bo
Department of Gastroenterology,Dalian Jiuzhou Century Hospital,Dalian 116400,Liaoning,China
关键词:
乌司他丁; 重症急性胰腺炎; 生长抑素
Keywords:
Ulinastatin; Severe acute pancreatitis; Somatostatin
分类号:
R576
DOI:
10.3969/j.issn.1006-1959.2019.01.050
文献标志码:
A
摘要:
目的 比较乌司他丁和生长抑素治疗重症急性胰腺炎的临床疗效。方法 选择我院2017年7月~2018年7月收治的68例重症急性胰腺炎患者，随机分为对照组32例和观察组36例，两组患者均接受常规治疗，对照组在此基础上应用生长抑素治疗，观察组使用乌司他丁治疗。记录两组患者上腹部压痛缓解时间、腹痛恢复时间、血淀粉酶恢复时间，IL-6、IL-8、IL-10、TNF-α改善水平，比较两组治疗有效率。结果 观察组患者的上腹部压痛缓解时间、腹痛恢复时间、血淀粉酶恢复时间均少于对照组，差异有统计学意义（P＜0.05）；观察组患者的IL-6、IL-8、IL-10、TNF-α改善效果均优于对照组，差异有统计学意义（P＜0.05）；观察组治疗有效率为94.44%，高于对照组的75.00%，差异有统计学意义（P＜0.05）。结论 应用乌司他丁为重症急性胰腺炎患者治疗可有效改善各项炎症介质，缩短各项指标和症状的改善时间，临床应用可行性高。
Abstract:
Objective To compare the clinical efficacy of ulinastatin and somatostatin in the treatment of severe acute pancreatitis.Methods 68 patients with severe acute pancreatitis admitted to our hospital from July 2017 to July 2018 were randomly divided into control group (n=32) and observation group (n=36). Both groups received routine treatment. The control group was based on this. Treatment with somatostatin was given and the observation group was treated with ulinastatin. The remission time of abdominal pain, the recovery time of abdominal pain, the recovery time of blood amylase, the improvement of IL-6, IL-8, IL-10 and TNF-α were recorded in the two groups.Results The pain relief time, abdominal pain recovery time and blood amylase recovery time of the observation group were lower than those of the control group, the difference was statistically significant (P<0.05).The improvement of IL-6, IL-8, IL-10 and TNF-α in the observation group was better than that in the control group,the difference was statistically significant (P<0.05). The effective rate of the observation group was 94.44%,compared with 75.00% of the control group, the difference was statistically significant (P<0.05).Conclusion The application of ulinastatin in patients with severe acute pancreatitis can effectively improve various inflammatory mediators, shorten the improvement time of various indicators and symptoms, and has high clinical application feasibility.

参考文献/References:

[1]江宗奇.乌司他丁与奥曲肽联合治疗急性重症胰腺炎的疗效观察[J].中国医院用药评价与分析,2016,16(1):26-28.
[2]李科军,向正国,陈旭峰,等.早期大剂量乌司他丁联合奥曲肽治疗对重症急性胰腺炎患者炎症因子和T淋巴细胞的影响[J].海南医学院学报,2015,21(7):929-932.
[3]孔繁静.乌司他丁对重症急性胰腺炎全身炎症反应的抑制作用及对疗效的影响[J].山西医药杂志,2015,44(1):27-29.
[4]曾杰,陈宁波,张健,等.IL-6、IL-8、IL-10、TNF-α在严重多发伤的表达及与预后的相关性研究[J].四川医学,2013,34(3):289-292.
[5]陈宁波,曾杰,李艳,等.应用乌司他丁治疗严重多发伤血清IL-6、IL-8、IL-10、TNF-α的表达及临床意义[J].四川医学,2013,34(1):1-4.
[6]陈健,黄莹,王磊,等.乌司他丁对急性重症胰腺炎患者血清ZO-1、occludin、IL-18水平影响的多中心研究[J].中国生化药物杂志,2014,34(5):101-103.
[7] Wang G,Liu Y,Zhou SF,et al.Effect of Somatostatin, Ulinastatin and Gabexate on the Treatment of Severe Acute Pancreatitis[J].American Journal of the Medical Sciences,2016,351(5):506-512.
[8]欧云崧,贾利猛,王明锋,等.生长抑素联合乌司他丁治疗急性重症胰腺炎患者的临床分析[J].中国医学前沿杂志(电子版),2014,6(4):84-86.

相似文献/References:

[1]盛海龙,方长太,查佳安.超声造影对重症急性胰腺炎并发早期急性肾损的诊断价值[J].医学信息,2022,35(09):171.[doi:10.3969/j.issn.1006-1959.2022.09.044]
　SHENG Hai-long,FANG Chang-tai,ZHA Jia-an.Diagnostic Value of Contrast-enhanced Ultrasonography in Severe Acute Pancreatitis Complicated with Early Acute Kidney Injury[J].Journal of Medical Information,2022,35(01):171.[doi:10.3969/j.issn.1006-1959.2022.09.044]
[2]车鹏博,阮继刚,郭 丹.红细胞分布宽度联合D-二聚体含量预测 急性胰腺炎严重程度的价值[J].医学信息,2018,31(12):73.[doi:10.3969/j.issn.1006-1959.2018.12.022]
　CHE Peng-bo,RUAN Ji-gang,GUO Dan.The Value of Red Blood Cell Distribution Width Combined with D-dimer Content in Predicting the Severity of Acute Pancreatitis[J].Journal of Medical Information,2018,31(01):73.[doi:10.3969/j.issn.1006-1959.2018.12.022]
[3]只茂叶.重症急性胰腺炎的发病机制与内镜治疗研究[J].医学信息,2022,35(11):68.[doi:10.3969/j.issn.1006-1959.2022.11.019]
　ZHI Mao-ye.The Pathogenesis and Endoscopic Treatment of Severe Acute Pancreatitis[J].Journal of Medical Information,2022,35(01):68.[doi:10.3969/j.issn.1006-1959.2022.11.019]
[4]甘维桃,曾 凡,冮绍斌.乌司他丁对膝关节置换术后关节炎症及周围肿胀的影响[J].医学信息,2019,32(02):161.[doi:10.3969/j.issn.1006-1959.2019.02.049]
　GAN Wei-tao,ZENG Fan,GANG Shao-bin.Effect of Ulinastatin on Joint Inflammation and Peripheral Swelling after Knee Joint Replacement[J].Journal of Medical Information,2019,32(01):161.[doi:10.3969/j.issn.1006-1959.2019.02.049]
[5]杨 雍,吕汝琦,刘 丹.早期无创正压通气对重症急性胰腺炎合并肺损伤的保护作用机制[J].医学信息,2019,32(03):55.[doi:10.3969/j.issn.1006-1959.2019.03.018]
　YANG Yong,LV Ru-qi,LIU Dan.Protective Mechanism of Early Noninvasive Positive Pressure Ventilation on Severe Acute Pancreatitis Complicated with Lung Injury[J].Journal of Medical Information,2019,32(01):55.[doi:10.3969/j.issn.1006-1959.2019.03.018]
[6]张恺悦,陈幼琼.乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究[J].医学信息,2019,32(04):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
　ZHANG Kai-yue,CHEN You-qiong.Effect of Ulinastatin Combined with Xuebijing on Coagulation Function and Systemic Inflammatory Response in Patients with Sepsis after Burn[J].Journal of Medical Information,2019,32(01):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
[7]李 贺,付 锐,孙远松,等.早期区域动脉灌注肝素治疗高脂血症性SAP的临床效果[J].医学信息,2019,32(10):99.[doi:10.3969/j.issn.1006-1959.2019.10.031]
　LI He,FU Rui,SUN Yuan-song,et al.Clinical Effect of Early Regional Arterial Infusion of Heparin inthe Treatment of SAP with Hyperlipidemia[J].Journal of Medical Information,2019,32(01):99.[doi:10.3969/j.issn.1006-1959.2019.10.031]
[8]杨巧侠,王成果,王元欣.乌司他丁预处理对HepG2细胞氧化损伤保护作用的研究[J].医学信息,2019,32(13):72.[doi:10.3969/j.issn.1006-1959.2019.13.020]
　YANG Qiao-xia,WANG Cheng-guo,WANG Yuan-xin.Protective Effect of Ulinastatin Pretreatment on Oxidative Damage in HepG2 Cells[J].Journal of Medical Information,2019,32(01):72.[doi:10.3969/j.issn.1006-1959.2019.13.020]
[9]陈智华.赤芍加清胰汤联合空肠营养治疗重症急性胰腺炎的临床效果[J].医学信息,2019,32(21):156.[doi:10.3969/j.issn.1006-1959.2019.21.052]
　CHEN Zhi-hua.Clinical Observation on Treatment of Severe Acute Pancreatitis with Chishao Plus Qingyi Decoction Combined with Jejunal Nutrition[J].Journal of Medical Information,2019,32(01):156.[doi:10.3969/j.issn.1006-1959.2019.21.052]
[10]魏一鸣.乌司他丁对体外循环二尖瓣置换术患者肺功能损伤及炎性因子的影响[J].医学信息,2020,33(09):142.[doi:10.3969/j.issn.1006-1959.2020.09.046]
　WEI Yi-ming.Effect of Ulinastatin on Lung Function Injury and Inflammatory Factors in Patients Undergoing Mitral Valve Replacement with Cardiopulmonary Bypass[J].Journal of Medical Information,2020,33(01):142.[doi:10.3969/j.issn.1006-1959.2020.09.046]

更新日期/Last Update: 2019-01-22