[1]沈云志,王毅军.miRNA及LncRNA在器官移植免疫排斥中作用的研究进展[J].医学信息,2019,32(02):43-47.[doi:10.3969/j.issn.1006-1959.2019.02.015]
　SHEN Yun-zhi,WANG Yi-jun.Advances in the Role of miRNA and LncRNA in Immune Rejection of Organ Transplantation[J].Journal of Medical Information,2019,32(02):43-47.[doi:10.3969/j.issn.1006-1959.2019.02.015]
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miRNA及LncRNA在器官移植免疫排斥中作用的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年02期
页码:
43-47
栏目:
综述
出版日期:
2019-01-15

文章信息/Info

Title:
Advances in the Role of miRNA and LncRNA in Immune Rejection of Organ Transplantation
文章编号:
1006-1959（2019）02-0043-05
作者:
沈云志; 王毅军
天津市第三中心医院肝胆外科，天津 300170
Author(s):
SHEN Yun-zhi; WANG Yi-jun
Department of Hepatobiliary Surgery,Tianjin Third Central Hospital,Tianjin 300170,China
关键词:
器官移植; 免疫排斥; 非编码RNA
Keywords:
Organ transplantation; Immune rejection; Non-coding RNA
分类号:
R392.4
DOI:
10.3969/j.issn.1006-1959.2019.02.015
文献标志码:
A
摘要:
器官移植是临床上治疗终末期器官衰竭的主要手段，关于器官移植免疫排斥的理论研究目前也非常深入和广泛，但是对于移植术后出现的急性和慢性排斥反应仍然没有得到有效的控制。近年来，非编码RNA（ncRNA）在免疫学中的作用成为人们研究的焦点，它是一类不具有编码蛋白质功能的单链RNA，其中包含两种目前研究最热的ncRNA，即miRNA和lncRNA。大量研究表明，这两种ncRNA在免疫系统的功能方面起着重要的调控作用，以其为基础的基因诊断和治疗在控制器官移植免疫排斥中有着十分重大的前景和意义。本文总结了关于miRNA
Abstract:
Organ transplantation is the main method for the treatment of end-stage organ failure in clinical practice. The theoretical research on immune rejection of organ transplantation is also very in-depth and extensive, but the acute and chronic rejection after transplantation has not been effectively controlled. In recent years, the role of non-coding RNA (ncRNA) in immunology has become the focus of research. It is a class of single-stranded RNA that does not have the function of encoding proteins. It contains two of the hottest ncRNAcurrently studied, namely miRNA and lncRNA.Numerous studies have shown that these two ncRNA play an important regulatory role in the function of the immune system, and their genetic diagnosis and treatment have great prospects and significance in controlling immune rejection of organ transplantation. This article summarizes the role of miRNAand lncRNA in immunological and organ transplant immunological rejection in order to achieve optimal control of organ transplant immune rejection and long-term graft survival.

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更新日期/Last Update: 2019-02-15