[1]李 莹,杨 宇,王 迪,等.Ang-2对肝再生作用机制的研究进展[J].医学信息,2019,32(03):31-33.[doi:10.3969/j.issn.1006-1959.2019.03.011]
 LI Ying,YANG Yu,WANG Di,et al.Progress in Research on the Mechanism of Ang-2 on Liver Regeneration[J].Journal of Medical Information,2019,32(03):31-33.[doi:10.3969/j.issn.1006-1959.2019.03.011]
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Ang-2对肝再生作用机制的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年03期
页码:
31-33
栏目:
综述
出版日期:
2019-02-01

文章信息/Info

Title:
Progress in Research on the Mechanism of Ang-2 on Liver Regeneration
文章编号:
1006-1959(2019)03-0031-03
作者:
李 莹1杨 宇1王 迪1张钊铜1刘 卓1王 玥1丁 隆2
(1.佳木斯大学,黑龙江 佳木斯 151100;2.佳木斯大学附属第一医院普外二科,黑龙江 佳木斯 154007)
Author(s):
LI Ying1YANG Yu1WANG Di1ZHANG Zhao-tong1LIU Zhuo1WANG Yue1DING Long2
(1.Jiamusi University,Jiamusi151100,Heilongjiang,China;2.General Surgery,the First Affiliated Hospital of Jiamusi University,Jiamusi 154007,Heilongjiang,China)
关键词:
肝再生Ang-2TGF-β1VEGF
Keywords:
Liver regenerationAng-2TGF-β1VEGF
分类号:
R735.7
DOI:
10.3969/j.issn.1006-1959.2019.03.011
文献标志码:
A
摘要:
对于肝脏的晚期病变,一般的治疗手段往往不能奏效,很多患者只能通过肝脏切除术或肝移植进行治疗,因此探究肝再生的影响因素就变得十分必要。近年来研究发现促血管生成素-2(Ang-2)在肝再生过程中发挥着极其重要的调控作用,本文对Ang-2及其受体做了简要概述,对近几年Ang-2在肝再生作用机制的研究情况进行综述。
Abstract:
For advanced lesions of the liver, general treatments often do not work. Many patients can only be treated by liver resection or liver transplantation. Therefore, it is necessary to explore the influencing factors of liver regeneration. In recent years, it has been found that angiopoietin-2 (Ang-2) plays an important role in the regulation of liver regeneration. This article gives a brief overview of Ang-2 and its receptors. The research on the mechanism of liver regeneration is reviewed.

参考文献/References:


[1]陈孝平,汪建平.外科学[M].第8版.北京:人民卫生出版社,2013:425-427.
[2]谢文勇,李涛.活体肝移植的研究进展[J].器官移植,2018,9(4):252-254.
[3]Asrani SK,Kamath PS.Natural history of cirrhosis[J].Curr Gastroenterol Rep,2013,15(2):308.
[4]潘杰斌,焦作义,张冬红,等.肝窦内皮细胞的研究进展[J].中国普外基础与临床杂志,2013,20(5):579-582.
[5]张杰,余晓岚.促血管生成素-2的研究进展[J].化学与生物工程,2014,31(9):1-7.
[6]Moss A.Theangiopoietin:tie 2 interaction:a potential target for future therapies in human vascular disease[J].Cytokine Growth Factor Rev,2013,24(6):579-592.
[7]朱月钮,傅立军,周爱卿.血管形成因子-1与肺动脉高压形成关系的研究[J].临床儿科杂志,2005,23(3):143-145.
[8]王爽,张晓玲.Ang-2、VEGF在子宫内膜异位症中的研究进展[J].实用临床医学,2008,9(8):132-134.
[9]任夏,施佳怡,李运红.血管生成素与急性胰腺炎相关性的研究进展[J].山东医药,2017,57(28):109-112
[10]冯仁鑫,邓星,张新,等.肝再生研究进展[J].胃肠病学,2015,20(3):169-173.
[11]解强,付文广,雷正明.肝星状细胞对肝再生的调控作用[J].现代医药卫生,2016,3(19):2990-2993.
[12]Hu J,Srivastava K,Wieland M,et al.Endothelial cell-derived angiopoietin-2 controls liver regeneration as spatiotemporal rheostat[J].Science,2014,343(6169):416-419.
[13]毕婉蓉,邢海林,金彩霞.转化生长因子-β1对小鼠肝纤维化的促进作用[J].同济大学学报,2014,35(6):12-16.
[14]尹继业,王少霞,刁瑞英,等.TGF-β1在肝再生调控中的作用研究[J].中国肝胆外科杂志,2008,14(4):261-264
[15]Lederer A,Seehofer D,Schirmerier A,et al.Postoperative bile leakage inhibits liver regeneration after 70% hepatectomy in rats[J].J Invest Surg,2013,26(1):36-45.
[16]Peng L,Jia X,Zhao J,et al.Substance P promotes hepatic stellate cell proliferation and activation via the TGF-β1/Samad-3 signaling pathway[J].Toxicology and Applied Pharmacology,2017(329):293-300.
[17]Russell WE,Coffey RJ,Ouellette AJ,et al.Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat[J].Proc Natl AcadSci USA,1988(85):5126-5130.
[18]Oe S,Lemmer ER,Conner EA,et al.Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice[J].Hepatology,2004(40):1098-1100.
[19]潘杰斌,焦作义,张冬红,等.血管内皮生长因子和转化生长因子-β1在肝再生过程中的表达[J].中华肝胆外科杂志,2013,19(10):767-770.
[20]Fagiani E,Christofori G. Angiopoietins in angiogenesis[J].Cancer Lett,2013,328(1):18-26.

更新日期/Last Update: 2019-02-25