[1]朱婷樱,鲍扬漪.术前LMR和FIB的检测对结直肠中分化腺癌患者的临床意义[J].医学信息,2019,(04):94-98.[doi:10.3969/j.issn.1006-1959.2019.04.031]
 ZHU Ting-ying,BAO Yang-yi.Clinical Significance of Preoperative LMR and FIB Detection in Patients with Differentiated Adenocarcinoma in Colorectal[J].Medical Information,2019,(04):94-98.[doi:10.3969/j.issn.1006-1959.2019.04.031]
点击复制

术前LMR和FIB的检测对结直肠中分化腺癌患者的临床意义()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年04期
页码:
94-98
栏目:
论著
出版日期:
2019-02-15

文章信息/Info

Title:
Clinical Significance of Preoperative LMR and FIB Detection in Patients with Differentiated Adenocarcinoma in Colorectal
文章编号:
1006-1959(2019)04-0094-05
作者:
朱婷樱鲍扬漪
(安徽医科大学第三附属医院肿瘤科,安徽 合肥 230061)
Author(s):
ZHU Ting-yingBAO Yang-yi
(Department of Oncology,the Third Affiliated Hospital of Anhui Medical University,Hefei 230061,Anhui,China)
关键词:
结直肠中分化腺癌淋巴细胞与单核细胞比值纤维蛋白原辅助诊断术前评估
Keywords:
Differentiated adenocarcinoma in colorectalLymphocyte to monocyte ratioFibrinogen Assisted diagnosisPreoperative evaluation
分类号:
R753.3
DOI:
10.3969/j.issn.1006-1959.2019.04.031
文献标志码:
A
摘要:
目的 探讨结直肠中分化腺癌患者术前淋巴细胞与单核细胞比值和纤维蛋白原在辅助诊断、术前评估中的价值。方法 收集2010年1月~2013年7月在安徽医科大学第三附属医院接受手术治疗的结直肠中分化腺癌患者100例设为观察组,另选同时期健康体检者50例设为对照组,比较两组LMR、FIB值。通过受试者工作曲线确定结直肠中分化腺癌患者LMR与FIB的最佳截断值,根据截断值分为高、低LMR组,高、低FIB组。分析LMR、FIB与结直肠癌患者临床特征的关系及与术后5年生存率的相关性。结果 观察组LMR值(3.39±1.48)低于对照组(5.27±0.98),观察组FIB值(3.63±0.60)g/L高于对照组(2.78±0.41)g/L,统计学意义显著(P<0.01)。LMR、FIB的最佳截断值分别为3.65、3.495 g/L。高LMR组远处转移率为4.65%,低于低LMR组的21.05%,高LMR组在Ⅲ~Ⅳ期的比率为44.19%,低于低LMR组的64.91%,差异有统计学意义(P<0.05)。高FIB组远处转移率的22.22%,高于低FIB组的4.35%,高FIB组在Ⅲ~Ⅳ的比率为66.67%,高于低FIB组的43.48%,高FIB组淋巴结转移率为59.26%,高于低FIB组的34.78%,差异均有统计学意义(P<0.05)。高LMR组5年生存率为76.74%,高于低LMR组的47.37%,低FIB组5年生存率为78.26%,高于高FIB组的44.44%,统计学意义显著(P<0.01)。结论 术前LMR、FIB对结直肠中分化腺癌患者的辅助诊断、术前评估有一定临床价值。
Abstract:
Objective To investigate the value of preoperative lymphocyte and monocyte ratio and fibrinogen in the diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal. Methods 100 patients with colorectal differentiated adenocarcinoma who underwent surgery in the Third Affiliated Hospital of Anhui Medical University from January 2010 to July 2013 were enrolled in the observation group, and 50 healthy subjects in the same period were selected as the control group. The LMR and FIB values of the two groups were compared. The best cutoff values of LMR and FIB in patients with differentiated adenocarcinoma in colorectal were determined by receiver working curve. According to the cutoff value, they were divided into high and low LMR groups, high and low FIB groups. To analyze the relationship between LMR, FIB and clinical features of colorectal cancer patients and the correlation with 5-year survival rate. Results The LMR value of the observation group (3.39±1.48) was lower than that of the control group (5.27±0.98), and the FIB value of the observation group (3.63±0.60) g/L was higher than that of the control group (2.78±0.41) g/L, which was statistically significant (P <0.01). The optimal cutoff values for LMR and FIB are 3.650 and 3.495 g/L, respectively. The distant metastasis rate of the high LMR group was 4.65%, Below 21.05% of the low LMR group, the ratio of the high LMR group was 44.19% in the III~IV phase, which was lower than the 64.91% in the low LMR group, the difference was statistically significant (P<0.05). The distant metastasis rate was 22.22% in the high FIB group,Compared with 4.35% in the low FIB group, the ratio of III to IV in the high FIB group was 66.67%, which was higher than 43.48% in the low FIB group, and the lymph node metastasis rate in the high FIB group was 59.26%, which was higher than that in the low FIB group 34.78%,the differences were statistically significant (P<0.05). The 5-year survival rate was 76.74% in the high LMR group, which was higher than the low LMR group 47.37%, and the 5-year survival rate was 78.26% in the low FIB group, which was higher than that in the high FIB group 44.44%,Statistically significant (P <0.01). Conclusion Preoperative LMR and FIB have certain clinical value in the auxiliary diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal cancer.

参考文献/References:


[1]Jemal A.Cancer statistics,2015[J].Ca A Cancer Journal for Clinicians,2015,60(5):277-300.
[2]Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015.[J].Ca A Cancer Journal for Clinicians,2016,66(2):115-132.
[3]O'Malley G,Treacy O,et al.Stromal cell PD-L1 inhibits CD8+ T-cell antitumor immune responses and promotes colon cancer[J].Cancer Immunol Res,2018,6(11):1426-1441.
[4]Han LH,Jia YB,Song QX,et al.Prognostic significance of preoperative lymphocyte-monocyte ratio in patients with resectable esophageal squamous cell carcinoma[J].Asian Pac J Cancer Prev,2015,16(6):2245-2250.
[5]Lieto E,Galizia G,Auricchio A,et al.Preoperative neutrophil to lymphocyte ratio and lmphocyte to monocyte ratio are prognostic factors in gastric cancers undergoing surgery[J].J Gastrontest surg,2017,21(11):1764-1774.
[6]Li YL,Pan YY,Jiao Y,et al.Peripheral blood lymphocyte/monocyte ratio predicts outcome for patients with diffuse large B cell lymphoma after standard first-line regimens[J].Annals of Hematology,2014,93(4):617-626.
[7]Yamagishi T,Fujimoto N,Nishi H,et al.Prognostic significance of the lymphocyte-to-monocyte ratio in patients with malignant pleural mesothelioma[J].Lung Cancer,2015,90(1):111-117.
[8]周建刚,邵荣.术前癌胚抗原、D-二聚体、纤维蛋白原水平与结直肠癌患者临床病理学特征及分期的相关性研究[J].国际消化病杂志,2017(5):330-333.
[9]Pichler M,Hutterer GC,Stojakovic T,et al.High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific,metastasis-free,as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients[J].British Journal of Cancer,2013,109(5):1123-1129.
[10]Tsai YD,Wang CP,Chen CY,et al.Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer[J].Head Neck,2014,36(7):947-953.
[11]Tuting T,de Visser KED.How neutrophils promote metastasis[J].Science,2016,352(6282):145-146.
[12]Qu X,Tang Y,Hua S.Immunological Approaches Towards Cancer and Inflammation A Cross Talk[J]. Frontiers in Immunology,2018(9):563.
[13]Mandarano M,Bellezza G,Belladonna ML,et al.Assessment of TILs,IDO-1,and PD-L1 in resected non-small cell lung cancer:an immunohistochemical study with clinicopathological and prognostic implications[J].Virchows Archiv,2018:1-10.
[14]Zeng DQ,Yu YF,Ou QY,et al.Prognostic and predictive value of tumor-infiltrating lymphocytes for clinical therapeutic research in patients with non-small cell lung cancer[J].Oncotarget,2016,7(12):13765-13781.
[15]Chen X,Wu J,Ying L,et al. Prognostic Significance of Pre-Operative Monocyte-to-Lymphocyte Ratio in Lung Cancer Patients Undergoing Radical Surgery[J].Laboratory Medicine,2018, 49(2):29-39.
[16]周超,闫军浩,唐坚,等.淋巴细胞单核细胞比值与结直肠癌临床特征及预后的相关性分析[J].肿瘤,2017,37(12):1297-1303.
[17]Yang J,Xu H,Guo X,et al.Pretreatment Inflammatory Indexes as Prognostic Predictors for Survival in Colorectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy[J].Scientific Reports,2018,8(1):3044.
[18]Sahni A,Simpsonhaidaris PJ,Sahni SK,et al.Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2)[J].Journal of Thrombosis & Haemostasis,2010,6(1):176-183.
[19]Chen P,Wang C,Cheng B,et al.Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer[J]. Oncotargets & Therapy,2017 (10):3107-3118.
[20]Huang W,Wang S,Zhang H,et al.Prognostic significance of combined fibrinogen concentration and neutrophil-to-lymphocyte ratio in patients with resectable non-small cell lung cancer[J]. Cancer Biology & Medicine,2018,15(1):88-96.
[21]Lee SE,Lee JH,Ryu KW,et al.Preoperative plasma fbrinogen level is a useful predictor of adjacent organ involvement in patients with advanced gastric cancer[J].Gastric Cancer,2012(12): 81-87.
[22]Li Y,Wei S,Wang J,et al.Analysis of the factors associated with abnormal coagulation and prognosis in patients with non-small cell lung cancer[J].Zhongguo Fei Ai Za Zhi,2014,17(11):789-796.
[23]Tang L,Liu K,Wang J,et al.High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer[J].Journal of Surgical Oncology,2010,102(5):428-432.
[24]覃罗,姚晖,徐亮,等.中性粒细胞与淋巴细胞比值联合检测纤维蛋白原对结直肠癌预后的判断价值[J]. 中国免疫学杂志,2017,33(4):527-532.

更新日期/Last Update: 2019-03-07