[1]周玲玲,鞠乐乐,颜 玉.结直肠癌患者手术前后血清IGF-1水平变化及临床价值分析[J].医学信息,2019,(04):121-123.[doi:10.3969/j.issn.1006-1959.2019.04.039]
 ZHOU Ling-ling,JU Le-le,YAN Yu.Analysis of Changes and Clinical Value of Serum IGF-1 Levels in Patients with Colorectal Cancer before and after Operation[J].Medical Information,2019,(04):121-123.[doi:10.3969/j.issn.1006-1959.2019.04.039]
点击复制

结直肠癌患者手术前后血清IGF-1水平变化及临床价值分析()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年04期
页码:
121-123
栏目:
临床研究
出版日期:
2019-02-15

文章信息/Info

Title:
Analysis of Changes and Clinical Value of Serum IGF-1 Levels in Patients with Colorectal Cancer before and after Operation
文章编号:
1006-1959(2019)04-0121-03
作者:
周玲玲鞠乐乐颜 玉
(佳木斯大学附属第一医院消化一科,黑龙江 佳木斯 154003)
Author(s):
ZHOU Ling-lingJU Le-leYAN Yu
(Department of Digestion,Subject One,the First Affiliated Hospital of Jiamusi University, Jiamusi 154003,Heilongjiang,China)
关键词:
IGF-1结直肠癌Dukes分期
Keywords:
IGF-1Colorectal cancerDukes staging
分类号:
R735.35
DOI:
10.3969/j.issn.1006-1959.2019.04.039
文献标志码:
A
摘要:
目的 用酶联免疫吸附测定法检测结直肠癌患者手术前后血清 IGF-1的含量,并探讨其手术前后血清水平变化及在结直肠癌发生发展中的作用。方法 选取在佳木斯大学附属第一医院首次确诊并行结直肠癌切除术患者共30例为观察组,于手术前清晨及术后30 d采集空腹静脉血。选取同时期体检健康者30例为对照组,采集体检当日空腹静脉血。用Elisa法检测两组患者血清IGF-1的含量,观察血清IGF-1含量在两组中的变化规律,分析IGF-1与结直肠癌临床各参数的关系。结果 观察组术前血清IGF-1水平为(200.48±42.25)ng/ml,高于观察组术后的(164.52±35.45)ng/ml和对照组的(146.26±43.14)ng/ml,差异有统计学意义(P<0.05);观察组术后血清IGF-1水平较对照组稍高,但差异无统计学意义(P>0.05);高分化、中分化者血清IGF-1水平低于低分化者,差异有统计学意义(P<0.05);Dukes分期中A+B和C+D期之间比较,差异有统计学意义(P<0.05)。结论 结直肠癌患者血清IGF-1参与结直肠癌的病变过程,是一种有促进细胞增殖、分化等多种生物学活性的细胞因子,可能作为结直肠癌发生、发展的重要预测指标及手术切除后手术效果的评定指标之一。
Abstract:
Objective To detect the serum levels of IGF-1 in patients with colorectal cancer before and after operation by enzyme-linked immunosorbent assay (ELISA), and to explore the changes of serum levels before and after operation and the development of colorectal cancer. Methods A total of 30 patients with primary colorectal cancer resection were enrolled in the First Affiliated Hospital of Jiamusi University. The fasting venous blood was collected in the early morning before surgery and 30 d after surgery. At the same time, 30 healthy subjects in the same period of physical examination were selected as the control group, and fasting venous blood was collected on the day of physical examination. Serum IGF-1 levels were measured by Elisa method. The changes of serum IGF-1 levels in the two groups were observed. The relationship between IGF-1 and clinical parameters of colorectal cancer was analyzed. Results The preoperative serum IGF-1 level in the observation group was (200.48±42.25) ng/ml, which was higher than that in the observation group (164.52±35.45) ng/ml and the control group (146.26±43.14) ng/ml,the difference was statistically significant (P<0.05). The level of serum IGF-1 in the observation group was slightly higher than that in the control group, but the difference was not statistically significant (P>0.05). The high-differentiation and moderately differentiated patients had low serum IGF-1 level. In the poorly differentiated, the difference was statistically significant (P<0.05); the difference between A+B and C+D in Dukes stage was statistically significant (P<0.05). Conclusion Serum IGF-1 in colorectal cancer patients is involved in the pathological process of colorectal cancer. It is a cytokine that promotes various biological activities such as cell proliferation and differentiation. It may be an important predictor and operation for colorectal cancer. One of the evaluation indicators of the surgical effect after resection.

参考文献/References:


[1]姜艳芳,魏志,孙自勤.中国青年大肠癌发病趋势分析[J].胃肠病学和肝病学杂志,2016,25(9):982-987.
[2]张明,石菊芳,黄慧瑶,等.中国人群结直肠癌疾病负担分析[J].中国流行病学杂志,2015,36(7):709-714.
[3]Shuang T,Fu M,Yang G,et al.The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells[J].Biochem Pharmacol,2018(12):143-152.
[4]Ding J,LI C,Tang J,et al.Higher expression of proteins in IGF/IR axes in colorectal cancer is associated with Type2 Diabetes Mellitus[J]. Pathol Oncol Res,2016,22(4):773-779.
[5]Simons CC,Schouten LJ,Godschalk RW,et al.Energy restriction at young age,genetic variants in the insulin like growth factor pathway and colorectal cancer risk in the NetherLands Cohort Study[J].Int J Cancer,2017,140(2):272-284.
[6]戚红霞,李晓虹,胡海强.血清IGF-1、IGFBP-3、VEGF及多项白介素在结直肠癌转移监测中的意义[J].海南医学院学报,2013,19(2):176-179.
[7]Zhou Y,Li S,Li J,et al.Effect of micro RNA-135a on cell proliferation, migration,invasion, apoptosis and tumor angiogenesis through the IGF-1/PI3K/Akt signaling pathway in nonsmall Cell lung cancer[J].Cell Physiol Biochem,2017,42(4):1431-1446.
[8]Wang H,Wang C,Tian W,et al.The crucial role of SRPK1 in IGF-1 induced EMT of human gastric cancer[J].Oncotarget,2017,8(42):72157-72166.
[9]Chi F,Wu R,Zeng YC,et al.Circulation insulin-likegrowth factor peptides and colorectal cancer risk: an updated systematic review and meta-analysis[J].Mol Biol Rep,2013,40(5):3583-3590.

相似文献/References:

[1]张西园.糖尿病与结直肠癌患者预后相关研究进展[J].医学信息,2018,(01):55.[doi:10.3969/j.issn.1006-1959.2018.01.020]
 ZHANG Xi-yuan.Research Progress in the Relationship between Diabetes and the Prognosis of Colorectal Cancer[J].Medical Information,2018,(04):55.[doi:10.3969/j.issn.1006-1959.2018.01.020]
[2]陈学敏,彭 琼.中性粒细胞与淋巴细胞比值联合癌胚抗原对结直肠癌早期诊断的研究[J].医学信息,2019,(02):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
 CHEN Xue-min,PENG Qiong.Early Diagnosis of Colorectal Cancer by Neutrophil-lymphocyte Ratio Combined with Carcinoembryonic Antigen[J].Medical Information,2019,(04):75.[doi:10.3969/j.issn.1006-1959.2019.02.022]
[3]李在明,魏正强.外泌体在结直肠癌中的研究进展[J].医学信息,2019,(03):42.[doi:10.3969/j.issn.1006-1959.2019.03.014]
 LI Zai-ming,WEI Zheng-qiang.Research Progress of Exosomes in Colorectal Cancer[J].Medical Information,2019,(04):42.[doi:10.3969/j.issn.1006-1959.2019.03.014]
[4]陈小玉,白 鍊,贺春香.结直肠癌根治手术患者营养状况调查[J].医学信息,2019,(05):83.[doi:10.3969/j.issn.1006-1959.2019.05.025]
 CHEN Xiao-yu,BAI Lian,HE Chun-xiang.Investigation on Nutritional Status of Patients Undergoing Radical Surgery for Colorectal Cancer[J].Medical Information,2019,(04):83.[doi:10.3969/j.issn.1006-1959.2019.05.025]
[5]李大略,赵资文,刘兆礼,等.加速康复外科对合并有糖尿病的结直肠癌患者术后炎症反应与营养代谢的影响[J].医学信息,2019,(07):67.[doi:10.3969/j.issn.1006-1959.2019.07.021]
 LI Da-lue,ZHAO Zi-wen,LIU Zhao-li,et al.Effect of Accelerated Rehabilitation Surgery on Postoperative Inflammatory Response and Nutrient Metabolism in Patients with Colorectal Cancer Complicated with Diabetes[J].Medical Information,2019,(04):67.[doi:10.3969/j.issn.1006-1959.2019.07.021]
[6]王逸飞,王 志,左宏波,等.伊利替康联合替吉奥在晚期结直肠癌治疗的临床研究[J].医学信息,2019,(07):158.[doi:10.3969/j.issn.1006-1959.2019.07.049]
 WANG Yi-fei,WANG Zhi,ZUO Hong-bo,et al.Clinical Study of Irinotecan Combined with Tegafur,Gimeracil and Oteracil Porassium Capsulesin the Treatment of Advanced Colorectal Cancer[J].Medical Information,2019,(04):158.[doi:10.3969/j.issn.1006-1959.2019.07.049]
[7]谢 勇,涂经楷,肖明盛,等.腹腔镜与传统开腹结直肠癌根治术手术效果对比[J].医学信息,2019,(11):98.[doi:10.3969/j.issn.1006-1959.2019.11.026]
 XIE Yong,TU Jing-kai,XIAO Ming-sheng,et al.Comparative of Laparoscopic and Traditional Open Radical Rectal Cancer Radical Operation[J].Medical Information,2019,(04):98.[doi:10.3969/j.issn.1006-1959.2019.11.026]
[8]李莎莎,李 芳,王卫峰,等.地中海饮食与结直肠癌的相关研究[J].医学信息,2019,(15):6.[doi:10.3969/j.issn.1006-1959.2019.15.003]
 LI Sha-sha,LI Fang,WANG Wei-feng,et al.Correlation between Mediterranean Diet and Colorectal Cancer[J].Medical Information,2019,(04):6.[doi:10.3969/j.issn.1006-1959.2019.15.003]
[9]孙 峰,鲍扬漪,朱 婷,等.晚期结直肠癌抗血管生成靶向治疗研究进展[J].医学信息,2019,(17):1.[doi:10.3969/j.issn.1006-1959.2019.17.001]
 SUN Feng,BAO Yang-yi,ZHU Ting,et al.Advances in Anti-angiogenesis Targeted Therapy for Advanced Colorectal Cancer[J].Medical Information,2019,(04):1.[doi:10.3969/j.issn.1006-1959.2019.17.001]
[10]崔爱惠,张新安,路 越.中医传统功法联合培土化毒方在SOX方案治疗 晚期结直肠癌中的临床疗效[J].医学信息,2019,(17):5.[doi:10.3969/j.issn.1006-1959.2019.17.002]
 CUI Ai-hui,ZHANG Xin-an,LU Yue.Clinical Efficacy of Traditional Chinese Medicine Combined with Peihuahuadu Recipe in the Treatment of Advanced Colorectal Cancer with SOX Regimen[J].Medical Information,2019,(04):5.[doi:10.3969/j.issn.1006-1959.2019.17.002]

更新日期/Last Update: 2019-03-07