[1]章 勇,李 秀.多索茶碱治疗慢性阻塞性肺疾病急性加重期患者的临床疗效[J].医学信息,2019,32(11):159-161.[doi:10.3969/j.issn.1006-1959.2019.11.048]
　ZHANG Yong,LI Xiu.Clinical Efficacy of Doxofylline in the Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Journal of Medical Information,2019,32(11):159-161.[doi:10.3969/j.issn.1006-1959.2019.11.048]
点击复制

多索茶碱治疗慢性阻塞性肺疾病急性加重期患者的临床疗效()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年11期
页码:
159-161
栏目:
药物与临床
出版日期:
2019-06-01

文章信息/Info

Title:
Clinical Efficacy of Doxofylline in the Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
文章编号:
1006-1959（2019）11-0159-03
作者:
章 勇; 李 秀
安徽医科大学第三附属医院呼吸内科，安徽 合肥 230061
Author(s):
ZHANG Yong; LI Xiu
Department of Respiratory Medicine,the Third Affiliated Hospital of Anhui Medical University, Hefei 230061,Anhui,China
关键词:
慢阻肺急性加重期; 多索茶碱; CAT评分; 血气分析
Keywords:
Key words：Acute exacerbation of chronic obstructive pulmonary disease; Doxofylline; CAT score;  Blood gas analysis
分类号:
R56
DOI:
10.3969/j.issn.1006-1959.2019.11.048
文献标志码:
A
摘要:
目的 探讨多索茶碱治疗慢性阻塞性肺疾病（COPD）急性加重期患者的临床疗效。方法 选取2017年9月~2018年8月我院收治的COPD急性加重期患者50例，随机分为观察组及对照组，各25例。对照组给予患者吸氧、抗感染、化痰及解痉平喘等治疗，观察组在对照组基础上加用多索茶碱0.3 g静滴治疗，比较两组动脉血气、CAT评分、临床疗效有效率。结果 治疗后，两组pH比较，差异无统计学意义（P＞0.05）；观察组PaO2高于对照组，PaCO2低于对照组，差异有统计学意义（P＜0.05）。观察组CAT评分低于对照组[（17.68±2.77）分 vs（19.76±2.60）分]，差异有统计学意义（P＜0.05）。观察组总有效率为88.00%，高于对照组的76.00%，差异有统计学意义（P＜0.05）。结论 多索茶碱治疗COPD急性加重期患者的临床治疗效果较好,患者的各项症状均得到缓解，值得临床使用。
Abstract:
Abstract：Objective To investigate the clinical efficacy of doxofylline in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 50 patients with acute exacerbations of COPD admitted to our hospital from September 2017 to August 2018 were randomly divided into observation group and control group, 25 cases each. The control group was given oxygen, anti-infection, phlegm and antispasmodic and antiasthmatic treatment. The observation group was treated with doxofylline 0.3 g intravenously on the basis of the control group. The arterial blood gas, CAT score and clinical efficacy were compared between the two groups.Results After treatment, there was no significant difference in pH between the two groups (P>0.05). PaO2 in the observation group was higher than that in the control group, and PaCO2 was lower than the control group, the difference was statistically significant (P<0.05). The CAT score of the observation group was lower than that of the control group [(17.68±2.77) points vs (19.76±2.60) points],the difference was statistically significant (P<0.05).The total effective rate of the observation group was 88.00%, which was higher than that of the control group 76.00%,the difference was statistically significant(P<0.05).Conclusion Doxofylline is effective in the treatment of patients with acute exacerbation of COPD. All have been alleviated and worthy of clinical use.

参考文献/References:

[1]Singh D,Agusti A,Anzueto A,et al.Global Strategy for the Diagnosis, Management,and Prevention of Chronic Obstructive Lung Disease:The GOLD Science Committee Report 2019[J].Eur Respir J,2019. [2]肖毅,蔡柏蔷.呼吸内科诊疗常规[M].第2版.北京:人民卫生出版社. [3]慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组.慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2017年更新版)[J].国际呼吸杂志,2017,37(14):1041-1057. [4]Shukla D,Chakraborty S,Singh S.Doxofylline:a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease[J].Expert Opin Pharmacother,2009(10):2343-2356. [5]van Mastbergen J,Jolas T,Allegra L,et al.The mechanism of action of doxofylline is unrelated to HDAC inhibition,PDE inhibition or adenosine receptor antagonism[J].Pulm Pharmacol Ther,2012,25(1):55-61. [6]Duffy N,Walker P,Diamantea F,et al.Intravenous aminophylline in patients admitted to hospital with non-acidotic exacerbations of chronic obstructive pulmonary disease:a prospective randomised controlled trial[J].Thorax,2005,60(9):713-717. [7]Lal D,Manocha S,Ray A,et al.Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease[J].J Basic Clin Physiol Pharmacol,2015(26):443-451. [8]袁雅冬,赵芳,王淑梅.左氧氟沙星对慢性阻塞性肺疾病急性加重患者的多索茶碱血药浓度的影响研究[J].中国药房,2017 ,37(6):3206-3209. [9]杨良芹,金桂兰.左氧氟沙星与多索茶碱联用引起中枢神经兴奋、失眠1例[J].中国医院用药评价与分析,2013,13(7):671-672.

相似文献/References:

[1]刘江海.异丙托溴铵雾化吸入治疗慢阻肺急性加重期的临床疗效[J].医学信息,2019,32(20):150.[doi:10.3969/j.issn.1006-1959.2019.20.047]
　LIU Jiang-hai.Clinical Efficacy of Ipratropium Bromide Inhalation in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Journal of Medical Information,2019,32(11):150.[doi:10.3969/j.issn.1006-1959.2019.20.047]
[2]武殿香.丙酸氟替卡松联合特布他林治疗COPD急性加重期的效果[J].医学信息,2019,32(21):143.[doi:10.3969/j.issn.1006-1959.2019.21.046]
　WU Dian-xiang.Effect of Fluticasone Propionate Combined with Terbutaline on Acute Exacerbation of COPD[J].Journal of Medical Information,2019,32(11):143.[doi:10.3969/j.issn.1006-1959.2019.21.046]
[3]曾丹丹,何英聪.糖皮质激素联合特布他林雾化治疗慢阻肺急性加重期患者的疗效及对炎症因子、肺功能的影响[J].医学信息,2022,35(23):129.[doi:10.3969/j.issn.1006-1959.2022.23.026]
　ZENG Dan-dan,HE Ying-cong.Effect of Glucocorticoid Combined with Terbutaline Atomization on Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and its Effect on Inflammatory Factors and Lung Function[J].Journal of Medical Information,2022,35(11):129.[doi:10.3969/j.issn.1006-1959.2022.23.026]

更新日期/Last Update: 2019-06-01