[1]石 沁,欧阳红梅,宋建新.血液病患者骨髓微环境和外周血部分细胞因子水平的对比[J].医学信息,2019,32(13):81-83.[doi:10.3969/j.issn.1006-1959.2019.13.022]
　SHI Qin,OUYANG Hong-mei,SONG Jian-xin.Comparison of Bone Marrow Microenvironment and Peripheral Blood Cytokine Levels in Patients with Hematological Diseases[J].Journal of Medical Information,2019,32(13):81-83.[doi:10.3969/j.issn.1006-1959.2019.13.022]
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血液病患者骨髓微环境和外周血部分细胞因子水平的对比()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年13期
页码:
81-83
栏目:
论著
出版日期:
2019-07-01

文章信息/Info

Title:
Comparison of Bone Marrow Microenvironment and Peripheral Blood Cytokine Levels in Patients with Hematological Diseases
文章编号:
1006-1959（2019）13-0081-03
作者:
石 沁1; 欧阳红梅2; 宋建新2
1.云南省临沧市云县人民医院检验科，云南 云县 675800； 2.云南省第一人民医院检验科，云南 昆明 650032
Author(s):
SHI Qin1; OUYANG Hong-mei2; SONG Jian-xin2
1.Department of Clinical Laboratory,Yunxian People's Hospital,Yunxian 675800,Yunnan,China; 2.Department of Clinical Laboratory,Yunnan First People's Hospital,Kunming 650032,Yunnan,China
关键词:
骨髓; 外周血; 细胞因子
Keywords:
Key words：Bone marrow; Peripheral blood; Cytokines
分类号:
R73
DOI:
10.3969/j.issn.1006-1959.2019.13.022
文献标志码:
A
摘要:
目的 探讨骨髓微环境中细胞因子IL-Iβ、IL-2、IL-4、IL-10、INF-γ、TNF-α水平与外周血中相应细胞因子的差异。方法选取2018年1月~2019年2月云南省第一人民医院血液科诊断的缺铁性贫血（IDA）、骨髓增生异常综合征（MDS-EB-1）、慢性粒细胞白血病慢性期（CML-CP）及急性髓系白血病（AML）患者各20例。应用流式细胞仪分析IDA、MDS-EB-1、CML-CP和AML患者骨髓及外周血IL-Iβ、IL-2、IL-4、IL-10、INF-γ、TNF-α的水平。结果 IDA患者骨髓微环境和外周血中细胞因子水平比较，差异无统计学意义（P＞0.05）；MDS-EB-1、CML-CP及AML患者骨髓微环境中IL-Iβ、IL-2、IL-4、IL-10、INF-γ、TNF-α水平高于外周血，差异有统计学意义（P＜0.05）。结论 IDA、MDS-EB-1、CML-CP及AML患者骨髓微环境中细胞因子IL-Iβ、IL-2、IL-4、IL-10、INF-γ、TNF-α的水平高于外周血中相应的细胞因子水平。在研究血液系统恶性肿瘤细胞因子时，应检测骨髓微环境中的细胞因子。
Abstract:
Abstract：Objective To investigate the differences of cytokines IL-Iβ, IL-2, IL-4, IL-10, INF-γ and TNF-α levels in the bone marrow microenvironment and corresponding cytokines in peripheral blood.Methods The iron deficiency anemia (IDA), myelodysplastic syndrome (MDS-EB-1) ,20 patients with chronic myeloid leukemia (CML-CP) and acute myeloid leukemia (AML). Flow cytometry was used to analyze the levels of IL-Iβ, IL-2, IL-4, IL-10, INF-γ and TNF-α in bone marrow and peripheral blood of patients with IDA, MDS-EB-1, CML-CP and AML.Results There was no significant difference in the cytokine levels between the bone marrow microenvironment and peripheral blood of patients with IDA (P>0.05).The levels of IL-Iβ, IL-2, IL-4, IL-10, INF-γ and TNF-α in the bone marrow microenvironment of patients with MDS-EB-1, CML-CP and AML were higher than those in peripheral blood,the difference was statistically significant(P<0.05).Conclusion The levels of cytokines IL-Iβ, IL-2, IL-4, IL-10, INF-γ and TNF-α in bone marrow microenvironment of patients with IDA, MDS-EB-1, CML-CP and AML are higher than those of peripheral blood. Corresponding cytokine levels. In the study of hematological malignancies cytokines, cytokines in the bone marrow microenvironment should be examined.

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相似文献/References:

[1]石 沁,欧阳红梅,宋建新.慢性淋巴细胞白血病患者骨髓INF-γ、IL-2、IL-4、IL-10及IL-1β水平的变化及意义[J].医学信息,2018,31(17):149.[doi:10.3969/j.issn.1006-1959.2018.17.047]
　SHI Qin,OUYANG Hong-mei,SONG Jian-xin.Changes and Significance of IFN-γ,IL-2,IL-4,IL-10 and IL-1β in Marrow of Patients with Chronic Lymphocytic Leukemia[J].Journal of Medical Information,2018,31(13):149.[doi:10.3969/j.issn.1006-1959.2018.17.047]

更新日期/Last Update: 2019-07-01