[1]王 猛.循环肿瘤细胞在肺癌诊疗中的临床研究进展[J].医学信息,2019,32(15):58-60.[doi:10.3969/j.issn.1006-1959.2019.15.019]
 WANG Meng.Progress in Clinical Research of Circulating Tumor Cells in the Diagnosis and Treatment of Lung Cancer[J].Journal of Medical Information,2019,32(15):58-60.[doi:10.3969/j.issn.1006-1959.2019.15.019]
点击复制

循环肿瘤细胞在肺癌诊疗中的临床研究进展()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年15期
页码:
58-60
栏目:
综述
出版日期:
2019-08-01

文章信息/Info

Title:
Progress in Clinical Research of Circulating Tumor Cells in the Diagnosis and Treatment of Lung Cancer
文章编号:
1006-1959(2019)15-0058-03
作者:
王 猛
天津市胸科医院胸外科,天津 300222
Author(s):
WANG Meng
Department of Thoracic Surgery,Tianjin Chest Hospital,Tianjin 300222,China
关键词:
肺癌循环肿瘤细胞反转录聚合酶链反应
Keywords:
Key words:Lung cancerCirculating tumor cellsReverse transcriptase polymerase chain reaction
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2019.15.019
文献标志码:
A
摘要:
肺癌现已成为发病率及致死率最高的恶性肿瘤,且呈逐年增高趋势,给人类的身体健康及生命安全带来严重威胁。肺癌的复发与转移是导致患者死亡的最主要原因,可能与循环肿瘤细胞(CTCs)进入血液存在一定关系,CTCs在肺癌患者的早期诊断、治疗指导、疗效评估及预后等方面具有十分重要的作用。本文就CTCs在肺癌诊疗中临床应用及研究进展进行综述。
Abstract:
Abstract:Lung cancer has become the malignant tumor with the highest incidence and mortality, and it is increasing year by year, posing a serious threat to human health and life safety. The recurrence and metastasis of lung cancer is the most important cause of death, which may be related to the entry of circulating tumor cells (CTCs) into the blood. CTCs play an important role in the early diagnosis, treatment guidance, efficacy evaluation and prognosis of lung cancer patients. . This article reviews the clinical application and research progress of CTCs in the diagnosis and treatment of lung cancer.

参考文献/References:

[1]聂启鸿,刘华峰,卢燕军.外周血循环肿瘤细胞上皮-间质转化机制调控的EP方案治疗小细胞肺癌的研究[J].重庆医学,2019,48(1):91-93. [2]刘磊,黄诚,李力,等.循环肿瘤细胞中不同表型细胞FGFR1基因表达程度与非小细胞肺癌临床病理特点相关性研究[J].中国肺癌杂志,2018,21(5):365-374. [3]张丽妍,谭晓明.循环肿瘤细胞检测在肺癌诊疗中的应用[J].上海交通大学学报(医学版),2018,38(3):343-347. [4]Pixberg CF,Raba K,Muller F,et al.Analysis of DNA methylation in single circulating tumor cells[J].Oncogene,2017,36(23):3223-3231. [5]Yadavalli S,Jayaram S,Manda SS,et al.Data-Driven Discovery of extravasation pathway in circulating tumor cells[J].Sci Rep,2017(7):43710. [6]李晶,姜北,万鹏,等.晚期非小细胞肺癌患者循环肿瘤细胞检测的临床意义[J].中国全科医学,2013,16(27):3202-3204,3207. [7]朱颖,江波,杨承纲,等.晚期非小细胞肺癌外周血CTC与肿瘤组织EGFR表达的相关性[J].中国现代医学杂志,2017,27(29):32-38. [8]蔡博,邓美洲,陈俊华,等.微流控芯片技术在循环肿瘤细胞富集和分析中的应用[J].中华实验外科杂志,2018,35(12):2369-2372. [9]沈敏娜,戴谦,周佳烨,等.481例恶性肿瘤患者循环肿瘤细胞(CTC)检测的回顾性分析[J].复旦学报(医学版),2018,45(6):769-774. [10]牛剑祥,宋瑞,王万祥.肝细胞癌循环肿瘤细胞的监测及其临床意义[J].中国老年学杂志,2019,39(4):800-802. [11]向森,焉然,张开芳.外周血循环肿瘤细胞对早期胃癌的诊断和预后评估价值[J].癌症进展,2019,17(6):693-696. [12]肖瑶,刘双,王增智,等.重组病毒特异性检测肺癌患者外周血活性循环肿瘤细胞的临床意义[J].中华结核和呼吸杂志,2019,42(2):101-105. [13]赵枰,洪煜婧,陈相.等.免疫磁珠负性富集结合免疫荧光抗体技术检测卵巢癌患者外周血CTCs的方法建立和应用[J].现代检验医学杂志,2017,32(3):56-58,62. [14]任慧子,陈健,丁世凯.EPCAM联合CK8免疫磁珠制备及循环肿瘤细胞检测[J].国际检验医学杂志,2018,39(14):1698-1700. [15]胡瑞娟,吴兆红.外周血循环肿瘤细胞与非小细胞肺癌患者临床分期的相关性[J].长江大学学报(自然版)理工,2018,15(8):29-31. [16]苗欣,赵家义,范银星,等.循环肿瘤细胞联合血清胃泌素释放前肽及神经元特异性烯醇化酶水平对SCLC化疗疗效的评估意义[J].中国肿瘤生物治疗杂志,2017,24(4):362-366. [17]吴文君,王智华,王卓,等.肺癌患者外周血中循环肿瘤细胞的快速分离与体外培养[J].遗传,2017,39(1):67-75. [18]Dorsey JF,Kao GD,Macarthur KM,et al.Tracking viable circulating tumor cells(CTCs)in the peripheral blood of non-small cell lung cancer(NSCLC)patients undergoing definitive radiation therapy:Pilot study results[J].Cancer,2015,121(1):139-149. [19]葛含天,朱万森,黄建中.循环肿瘤细胞定量检测在非小细胞肺癌患者中的应用价值研究[J].中国全科医学,2017,20(S3):144-146. [20]Xu Y,Qin T,Li J,et al.Detection of circulating tumor cells using negative enrichment immunofluorescence and an in situ hybridization system in pancreatic cancer[J].International Journal of Molecular Sciences,2017,18(4):622-630. [21]钟光华,刘丽贤,朱晓慧,等.循环肿瘤细胞检测在预测非小细胞肺癌化疗疗效中的应用[J].实用癌症杂志,2017,32(9):1521-1523. [22]范军振,吕亚莉,王波,等.非转移性非小细胞肺癌患者循环肿瘤细胞与临床病理特征的关系[J].诊断病理学杂志,2018,25(4):281-284,288. [23]张晓茜,范贤明.循环肿瘤细胞与肺癌患者预后相关性的Meta分析[J].临床合理用药杂志,2018,11(12):144-146. [24]叶春晖,陈亮,王继鹏,等.培美曲塞联合顺铂对晚期非小细胞肺癌患者外周血循环肿瘤细胞EGFR表达及预后的影响[J].中国医学前沿杂志(电子版),2017,9(12):34-37. [25]李发凯,陆远,王媛,等.循环肿瘤细胞检测在非小细胞肺癌化疗疗效评价中的应用[J].国际呼吸杂志,2018,38(12):898-903. [26]汪代杰,尹雷,周梅,等.预测非小细胞肺癌化疗患者循环肿瘤细胞检测的应用分析[J].临床医药文献电子杂志,2018,5(69):176. [27]郑张军,张金星.不同分子学方法在乳腺癌患者外周血循环肿瘤细胞检测中的应用[J].临床检验杂志(电子版),2019,8(1):97-98.

相似文献/References:

[1]尤 静.肺癌患者外周血CEA、NSE、CYFRA21-1联合检测的意义[J].医学信息,2018,31(06):149.[doi:10.3969/j.issn.1006-1959.2018.06.052]
 YOU Jing.Clinical Significance of Combined Detection of CEA,NSE,CYFRA21-1 in Peripheral Blood of Patients with Lung Cancer[J].Journal of Medical Information,2018,31(15):149.[doi:10.3969/j.issn.1006-1959.2018.06.052]
[2]戴 芳,曹晓美,王莉娜.肺癌患者疾病不确定感的影响因素与干预措施研究现状[J].医学信息,2018,31(08):35.[doi:10.3969/j.issn.1006-1959.2018.08.012]
 DAI Fang,CAO Xiao-mei,WANG Li-na.Research Status on Influencing Factors and Intervention Measures of Disease Uncertainty in Patients with Lung Cancer[J].Journal of Medical Information,2018,31(15):35.[doi:10.3969/j.issn.1006-1959.2018.08.012]
[3]吴 倩,王一非.中西医结合治疗肺癌脑转移疗效与安全性的Meta分析[J].医学信息,2022,35(10):120.[doi:10.3969/j.issn.1006-1959.2022.10.029]
 WU Qian,WANG Yi-fei.Meta-analysis of Efficacy and Safety of Integrated Traditional Chinese and Western Medicine in the Treatment of Brain Metastasis of Lung Cancer[J].Journal of Medical Information,2022,35(15):120.[doi:10.3969/j.issn.1006-1959.2022.10.029]
[4]王晓军.以时间护理为基础的呼吸训练与排痰管理对肺癌手术患者康复的影响研究[J].医学信息,2022,35(11):180.[doi:10.3969/j.issn.1006-1959.2022.11.048]
 WANG Xiao-jun.Effect of Respiratory Training and Expectoration Management Based on Time Nursing on Rehabilitation of Patients with Lung Cancer Surgery[J].Journal of Medical Information,2022,35(15):180.[doi:10.3969/j.issn.1006-1959.2022.11.048]
[5]邢益辉,刘 曼,厉玛倩倩,等.快速康复对肺癌手术患者并发症发生及生活质量的影响研究[J].医学信息,2018,31(16):168.[doi:10.3969/j.issn.1006-1959.2018.16.054]
 XING Yi-hui,LIU Man,LIMA Qian-qian,et al.Effect of Rapid Rehabilitation on Complications and Quality of Life in Patients with Lung Cancer Surgery[J].Journal of Medical Information,2018,31(15):168.[doi:10.3969/j.issn.1006-1959.2018.16.054]
[6]朱晓晓,张 顺,蔡 挺.镍暴露相关的肺癌发生分子机制研究[J].医学信息,2018,31(17):4.[doi:10.3969/j.issn.1006-1959.2018.17.002]
 ZHU Xiao-xiao,ZHANG Shun,CAI Ting.Molecular Mechanism of Lung Cancer Related to Nickel Exposure[J].Journal of Medical Information,2018,31(15):4.[doi:10.3969/j.issn.1006-1959.2018.17.002]
[7]付云杰.肺癌患者血浆D-二聚体、NSE及CYFRA21-1联合检测的临床价值[J].医学信息,2018,31(23):161.[doi:10.3969/j.issn.1006-1959.2018.23.047]
 FU Yun-jie.Clinical Value of the Plasma D-dimer and Serum NSE,CYFRA21-1 Combined Detection in the Diagnosis of Lung Cancer[J].Journal of Medical Information,2018,31(15):161.[doi:10.3969/j.issn.1006-1959.2018.23.047]
[8]覃柳麻,何慧敏.2014~2016年广西肿瘤医院肺癌患者流行病学及病理分布特征分析[J].医学信息,2019,32(05):67.[doi:10.3969/j.issn.1006-1959.2019.05.021]
 QIN Liu-ma,HE Hui-min.Epidemiological and Pathological Distribution Characteristics of Lung Cancer Patients in Guangxi Cancer Hospital from 2014 to 2016[J].Journal of Medical Information,2019,32(15):67.[doi:10.3969/j.issn.1006-1959.2019.05.021]
[9]魏优蕾,郭晓彤.肺癌患者血浆检测肿瘤标志物的分析方法及展望[J].医学信息,2019,32(07):39.[doi:10.3969/j.issn.1006-1959.2019.07.014]
 WEI You-lei,GUO Xiao-Tong.Analytical Methods and Prospects of Plasma Detection of Tumor Markers in Patients with Lung Cancer[J].Journal of Medical Information,2019,32(15):39.[doi:10.3969/j.issn.1006-1959.2019.07.014]
[10]杨寿林,宋庆志,吴路发,等.肿瘤标志物和凝血指标在肺癌辅助诊断中的效果分析[J].医学信息,2019,32(07):168.[doi:10.3969/j.issn.1006-1959.2019.07.053]
 YANG Shou-lin,SONG Qing-zhi,WU Lu-fa,et al.Efficacy Analysis of Tumor Markers and Coagulation Parameters in the Diagnosis of Lung Cancer[J].Journal of Medical Information,2019,32(15):168.[doi:10.3969/j.issn.1006-1959.2019.07.053]

更新日期/Last Update: 2019-08-01