[1]尚 波,金 菁.红细胞分布宽度在卒中后抑郁患者血清中的变化 及与炎症因子的关系[J].医学信息,2019,32(16):80-83.[doi:10.3969/j.issn.1006-1959.2019.16.024]
　SHANG Bo,JIN Jing.Changes of Erythrocyte Distribution Width in Serum of Patients with Post-stroke Depression and Its Relationship with Inflammatory Factors[J].Journal of Medical Information,2019,32(16):80-83.[doi:10.3969/j.issn.1006-1959.2019.16.024]
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红细胞分布宽度在卒中后抑郁患者血清中的变化 及与炎症因子的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年16期
页码:
80-83
栏目:
论著
出版日期:
2019-08-15

文章信息/Info

Title:
Changes of Erythrocyte Distribution Width in Serum of Patients with Post-stroke Depression and Its Relationship with Inflammatory Factors
文章编号:
1006-1959（2019）16-0080-04
作者:
尚 波; 金 菁
常州市第一人民医院神经内科，江苏 常州 213000
Author(s):
SHANG Bo; JIN Jing
Department of Neurology,Changzhou First People's Hospital,Changzhou 213000,Jiangsu,China
关键词:
红细胞分布宽度; 卒中后抑郁; 炎症因子
Keywords:
Key words：Red blood cell distribution width; Post-stroke depression; Inflammatory factors
分类号:
R749.4
DOI:
10.3969/j.issn.1006-1959.2019.16.024
文献标志码:
A
摘要:
目的 探究红细胞分布宽度（RDW）在卒中后抑郁（PSD）患者血清中的变化情况及与炎症因子的关系。方法 选取2018年10月~2019年4月我院收治的首发缺血性脑卒中患者90例，按照汉密尔顿抑郁量表（HAMD）评估法分为PSD组（38例）和非PSD组（52例），比较两组临床资料，并分析PSD与HAMD相关性及RDW与PSD发生风险及炎症因子间的关系。结果 两组年龄、高血压史、糖尿病史、Hb、MCHC、RDW、MCV比较，差异无统计学意义（P＞0.05）；两组性别、RBC、MCH、IL-6、TNF-α、IL-10比较，差异有统计学意义（P＜0.05）。IL-6、TNF-α与HAMD评分呈正相关（r=0.323、0.329，P＜0.05）。Logistic回归分析显示，IL-6和TNF-α是PSD发生的危险因素。PSD组RDW与IL-6呈正相关（r=0.457，P＜0.05）。结论 IL-6和TNF是PSD发生的危险因素，RDW可能通过介导炎症机制参与PSD的发生。
Abstract:
Abstract：Objective To investigate the changes of red blood cell distribution width (RDW) in serum of patients with post-stroke depression (PSD) and its relationship with inflammatory factors. Methods A total of 90 patients with first ischemic stroke admitted to our hospital from October 2018 to April 2019 were enrolled. According to the Hamilton Depression Scale (HAMD) assessment, they were divided into PSD group (38 cases) and non-PSD group (52 cases), compare the clinical data of the two groups, and analyze the relationship between PSD and HAMD and the relationship between RDW and PSD risk and inflammatory factors. Results There were no significant differences in age, history of hypertension, history of diabetes, Hb, MCHC, RDW and MCV between the two groups (P>0.05). Gender, RBC, MCH, IL-6, TNF-α, IL-10 The difference was statistically significant (P< 0.05). IL-6 and TNF-α were positively correlated with the HAMD score (r=0.323，0.329, P< 0.05). Logistic regression analysis showed that IL-6 and TNF-α were risk factors for PSD. RDW in the PSD group was positively correlated with IL-6 (r=0.457, P< 0.05).Conclusion IL-6 and TNF are risk factors for PSD. RDW may participate in the development of PSD through mediating inflammation.

参考文献/References:

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更新日期/Last Update: 2019-08-15