[1]丁 黎.Peyronie病的临床诊治研究[J].医学信息,2019,32(17):45-49.[doi:10.3969/j.issn.1006-1959.2019.17.015]
　DING Li.Clinical Diagnosis and Treatment of Peyronie's Disease[J].Journal of Medical Information,2019,32(17):45-49.[doi:10.3969/j.issn.1006-1959.2019.17.015]
点击复制

Peyronie病的临床诊治研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年17期
页码:
45-49
栏目:
综述
出版日期:
2019-09-01

文章信息/Info

Title:
Clinical Diagnosis and Treatment of Peyronie's Disease
文章编号:
1006-1959（2019）17-0045-05
作者:
丁 黎
孝感市第一人民医院，湖北 孝感 432000
Author(s):
DING Li
The First People's Hospital of Xiaogan City,Xiaogan 432000,Hubei,China
关键词:
Peyronie病; 阴茎畸形; 流行病学; 阴茎白膜
Keywords:
Key words：Peyronie disease; Penile malformation; Epidemiology; Penis white film
分类号:
R697.17
DOI:
10.3969/j.issn.1006-1959.2019.17.015
文献标志码:
A
摘要:
Peyronie病（PD）确切病因尚不明确，目前被认为是一些易感人群因为阴茎白膜的损伤（重复的小血管损伤或创伤）导致其创伤修复障碍，并最终形成纤维斑块，导致阴茎畸形、疼痛、插入困难及勃起功能障碍等。PD不仅是患者身体上的一种畸形，更是对其心理上的一种毁灭性打击。由于目前对PD病理生理的不完全理解及对该病的一些误解导致其治疗进展受限，使PD成为一种具有挑战性的疾病。根据目前的一些相关研究，绝大多数口服药物因疗效不确切而不被推荐常规使用，一些局部药物治疗及外力治疗等疗效尚存争议，而作为矫正阴茎畸形金标准的手术治疗则有导致阴茎缩短、术后ED的风险等，如何选择一种合适的治疗方案成为了困扰患者及泌尿外科医生的难题。本文整理美国泌尿学协会（AUA）和欧洲泌尿学协会（EAU）治疗PD的最新指南以及国内外治疗PD的相关研究，主要对PD的相关危险因素、流行病学及临床诊治进行综述，旨在为临床治疗PD提供参考。
Abstract:
Abstract：The exact cause of Peyronie's disease (PD) is unclear and is currently considered to be a susceptible population due to penile tunica albuginea (repetitive small vessel injury or trauma) resulting in a wound repair disorder that eventually leads to fibrous plaque, leading to penile malformations, pain, difficulty in insertion, and erectile dysfunction. PD is not only a deformity on the patient's body, but also a psychologically devastating blow. Due to the current incomplete understanding of the pathophysiology of PD and some misunderstanding of the disease, its treatment progress is limited, making PD a challenging disease. According to some current related research, the vast majority of oral drugs are not recommended for routine use because of inaccurate efficacy. Some local drug treatments and external treatments are still controversial, and surgical treatment as a standard for correcting penile malformation leads to penis. Shortening, the risk of postoperative ED, etc. How to choose a suitable treatment plan becomes a problem that plagues patients and urologists. This article reorganizes the latest guidelines for the treatment of PD by the American Association of Urology (AUA) and the European Association of Urology (EAU), as well as related studies on PD treatment at home and abroad, focusing on the related risk factors, epidemiology and clinical diagnosis and treatment of PD. Provide a reference for clinical treatment of PD.

参考文献/References:

[1]Levine LA,Burnett AL.Standard operating procedures for Peyronie's disease[J].J Sex Med,2013,10(1):230-244. [2]Gabrielson AT,Spitz JT,Hellstrom WJG.Collagenase Clostridium Histolyticum in the Treatment of Urologic Disease:Current and Future Impact[J].Sexual Medicine Reviews,2018,6(1):143-156. [3]Stuntz M,Perlaky A,des Vignes F,et al.The Prevalence of Peyronie's Disease in the United States:A Population-Based Study[J].PloS One,2016,11(2):e0150157. [4]Bilgutay AN,Pastuszak AW.Peyronie's Disease:A Review Of Etiology,Diagnosis,and Management[J].Current Sexual Health Reports,2015,7(2):117-131. [5]Milenkovic U,Ilg MM,Cellek S,et al.Pathophysiology and Future Therapeutic Perspectives for Resolving Fibrosis in Peyronie's Disease[J].Sex Med Rev,2019,S2050-0521(19)30011-30013. [6]Hatzimouratidis K,Giuliano F,Moncada I,et al.EAU guidelines on Erectile dysfunction,Premature Ejaculation,Penile Curvature and Priapism[J].EAU Annual Congress London,2017:978-990-79754-79791-79755. [7]Askari M,Mohamad Mirjalili SA,Bozorg M,et al.The prevalence of Peyronie's disease in diabetic patients -2018- Yazd[J].Diabetes & Metabolic Syndrome,2019,13(1):604-607. [8]Al-Thakafi S,Al-Hathal N.Peyronie's disease:a literature review on epidemiology,genetics,pathophysiology,diagnosis and work-up[J].Translational Andrology and Urology,2016,5(3):280-289. [9]Shindel AW,Sweet G,Thieu W,et al.Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures[J].Sexual Medicine,2017,5(3):e135-e141. [10]Herati AS,Pastuszak AW.The Genetic Basis of Peyronie Disease:A Review[J].Sexual Medicine Reviews,2016,4(1):85-94. [11]Chung E,Ralph D,Kagioglu A,et al.Evidence-Based Management Guidelines on Peyronie's Disease[J].The Journal of Sexual Medicine,2016,13(6):905-923. [12]Hussein AA,Alwaal A,Lue TF.All about Peyronie's disease[J].Asian Journal of Urology,2015,2(2):70-78. [13]Berookhim BM,Choi J,Alex B,et al.Deformity stabilization and improvement in men with untreated Peyronie's disease[J].BJU International,2014,113(1):133-136. [14]Davis SN,Ferrar S,Sadikaj G,et al.Female Partners of Men With Peyronie's Disease Have Impaired Sexual Function,Satisfaction,and Mood,While Degree of Sexual Interference Is Associated With Worse Outcomes[J].The Journal of Sexual Medicine,2016,13(7):1095-1103. [15]Nelson CJ,Diblasio C,Kendirci M,et al.The chronology of depression and distress in men with Peyronie's disease[J].The Journal of Sexual Medicine,2008,5(8):1985-1990. [16]Hellstrom WJ,Feldman R,Rosen RC,et al.Bother and distress associated with Peyronie's disease:validation of the Peyronie's disease questionnaire[J].The Journal of Urology,2013,190(2):627-634. [17]Coyne KS,Currie BM,Thompson CL,et al.Responsiveness of the Peyronie's Disease Questionnaire (PDQ)[J].The Journal of Sexual Medicine,2015,12(4):1072-1079. [18]Bekos A,Arvaniti M,Hatzimouratidis K,et al.The natural history of Peyronie's disease:an ultrasonography-based study[J].European Urology,2008,53(3):644-650. [19]Levine LA,Greenfield JM.Establishing a standardized evaluation of the man with Peyronie's disease[J].International Journal of Impotence Research,2003,15(Suppl 5):S103-S112. [20]Jung DC,Park SY,Lee JY.Penile Doppler ultrasonography revisited[J].Ultrasonography,2018,37(1):16-24. [21]Hauck EW,Hackstein N,Vosshenrich R,et al.Diagnostic value of magnetic resonance imaging in Peyronie's disease--a comparison both with palpation and ultrasound in the evaluation of plaque formation[J].European Urology,2003,43(3):293-299. [22]Nehra A,Alterowitz R,Culkin DJ,et al.Peyronie's Disease:AUA Guideline[J].The Journal of Urology,2015,194(3):745-753. [23]Kayes O,Khadr R.Recent advances in managing Peyronie's disease[J].F1000Research,2016,5(F1000 Faculty Rev):2372. [24]Russo GI,Milenkovic U,Hellstrom W,et al.Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease:A Systematic Review of the Literature[J]. European Urology,2018,74(6):767-781. [25]Sokhal AK,Jain NK,Jhanwar A,et al.Prospective study to evaluate the clinical outcome of intralesional interferon-α2b in the management of Peyronie's disease[J]. Urology Annals,2018,10(2):154-158. [26]Ziegelmann MJ,Viers BR,Montgomery BD,et al.Self-reported Clinical Meaningfulness Early in the Treatment Course Predicts Objective Outcomes in Men Undergoing Collagenase Clostridium histolyticum Injections for Peyronie Disease[J].Urology,2017(106):107-112. [27]Hellstrom WJG,Tan RBW,Liu G.Safety Profile of Collagenase Clostridium Histolyticum Stratified by Degree of Penile Curvature in Patients With Peyronie Disease[J].Urology,2017, 106(237):e9-e14. [28]Abdel Raheem A,Capece M,Kalejaiye O,et al.Safety and effectiveness of collagenase clostridium histolyticum in the treatment of Peyronie's disease using a new modified shortened protocol[J].BJU International,2017,120(5):717-723. [29]Carson CC,Sadeghi-Nejad H,Tursi JP,et al.Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease(PD)[J].BJU International,2015,116(5):815-822. [30]Martínez-Salamanca JI,Egui A,Moncada I,et al.Acute phase Peyronie's disease management with traction device:a nonrandomized prospective controlled trial with ultrasound correlation[J].The Journal of Sexual Medicine,2014,11(2):506-515. [31]Yafi FA,Pinsky MR,Sangkum P,et al.Therapeutic advancesin the treatment of Peyronie's disease[J].Andrology,2015,3(4):650-660. [32]Moncada I,Krishnappa P,Romero J,et al.Penile traction therapy with the new device "Penimaster PRO" is effective and safe in the stable phase of Peyronie's disease:a controlled multicentre study[J].BJU International,2019,123(4):694-702. [33]Chung E.Penile Reconstructive Surgery in Peyronie Disease:Challenges in Restoring Normal Penis Size,Shape,and Function[J].The World Journal of Men's Health,2018. [34]Carson CC,Levine LA.Outcomes of surgical treatment of Peyronie's disease[J].BJU International,2014,113(5):704-713. [35]Hatzichristodoulou G,Osmonov D,Kübler H,et al.Contemporary Review of Grafting Techniques for the Surgical Treatment of Peyronie's Disease[J].Sexual Medicine Reviews,2017,5(4):544-552. [36]Seveso M,Melegari S,De Francesco O,et al.Surgical correction of Peyronie's disease via tunica albuginea plication:long-term follow-up[J].Andrology,2018,6(1):47-52. [37]Chow AK,Sidelsky SA,Levine LA.Surgical Outcomes of Plaque Excision and Grafting and Supplemental Tunica Albuginea Plication for Treatment of Peyronie's Disease With Severe Compound Curvature[J].The Journal of Sexual Medicine,2018,15(7):1021-1029. [38]Bilgutay AN,Pastuszak AW.Peyronie's disease:What's around the bend?[J].Journal of the Urological Society of India,2016,32(1):6-14. [39]Dalkin BL,Carter MF.Venogenic impotence following dermal graft repair for Peyronie's disease[J].The Journal of Urology,1991,146(3):849-851. [40]Kadioglu A,Akman T,Sanli O,et al.Surgical treatment of Peyronie's disease:a critical analysis[J].European Urology,2006,50(2):235-248. [41]Garaffa G,Sacca A,Christopher AN,et al.Circumcision is not mandatory in penile surgery[J].BJU International,2010,105(2):222-224. [42]Taylor FL,Levine LA.Peyronie's Disease[J].The Urologic Clinics of North America,2007,34(4):517-534. [43]Garcia-Gomez B,Ralph D,Levine L,et al.Grafts for Peyronie's Disease:a comprehensive Review[J].Andrology,2018,6(1):117-126. [44]Levine LA,Estrada CR.Human cadaveric pericardial graft for the surgical correction of Peyronie's disease[J].The Journal of Urology,2003,(170):2359-2362. [45]Molina-Escudero R,Alvarez-Ardura M,Redón-Gálvez L,et al.Cavernoplasty with oral mucosa graft for the surgical treatment of Peyronie's disease[J].Actas Urologicas Espanolas,2016,40(5):328-332. [46]Cormio L,Mancini V,Massenio P,et al.Combined Plaque Incision,Buccal Mucosa Grafting,and Additional Tunica Albuginea Plication for Peyronie's Disease[J].Sexual Medicine,2019,7(1):48-53. [47]Levine LA,Becher EF,Bella AJ,et al.Penile Prosthesis Surgery:Current Recommendations From the International Consultation on Sexual Medicine[J].The Journal of Sexual Medicine,2016,13(4):489-518. [48]Khera M,Bella A,Karpman E,et al.Penile Prosthesis Implantation in Patients With Peyronie's Disease:Results of the PROPPER Study Demonstrates a Decrease in Patient-Reported Depression[J].The Journal of Sexual Medicine,2018,15(5):786-788. [49]Chung E,Solomon M,DeYoung L,et al.Comparison between AMS 700 CX and Coloplast Titan inflatable penile prosthesis for Peyronie's disease treatment and remodeling: clinical outcomes and patient satisfaction[J].The Journal of Sexual Medicine,2013,10(11):2855-2860. [50]Chung PH,Scott JF,Morey AF.High patient satisfaction of inflatable penile prosthesis insertion with synchronous penile plication for erectile dysfunction and Peyronie's disease[J].The Journal of Sexual Medicine,2014,11(6):1593-1598 [51]Wilson SK,Delk JR.A new treatment for Peyronie's disease:modeling the penis over an inflatable penile prosthesis[J].The Journal of Urology,1994,152(4):1121-1123. [52]Rolle L,Falcone M,Ceruti C,et al.A prospective multicentric international study on the surgical outcomes and patients' satisfaction rates of the ＇sliding＇ technique for end-stage Peyronie's disease with severe shortening of the penis and erectile dysfunction[J].BJU International,2016,117(5):814-820. [53]Egydio PH,Kuehhas FE.Penile lengthening and widening without grafting according to a modified ＇sliding＇ technique[J].BJU International,2015,116(6):965-972.

更新日期/Last Update: 2019-09-01