[1]罗巧彦,凌止发,严宗逊,等.中老年女性骨代谢指标与骨质疏松的相关性研究[J].医学信息,2019,32(17):68-71.[doi:10.3969/j.issn.1006-1959.2019.17.021]
　LUO Qiao-yan,LING Zhi-fa,YAN Zong-xun,et al.Correlation between Bone Metabolic Markers and Osteoporosis in Middle-aged and Elderly Women[J].Journal of Medical Information,2019,32(17):68-71.[doi:10.3969/j.issn.1006-1959.2019.17.021]
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中老年女性骨代谢指标与骨质疏松的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年17期
页码:
68-71
栏目:
论著
出版日期:
2019-09-01

文章信息/Info

Title:
Correlation between Bone Metabolic Markers and Osteoporosis in Middle-aged and Elderly Women
文章编号:
1006-1959（2019）17-0068-04
作者:
罗巧彦1; 凌止发2; 严宗逊1; 陈 敏 1; 李 玲1; 彭乙华1; 黄晓佳1
川北医学院附属医院内分泌科1，输血科2，四川 南充 637000
Author(s):
LUO Qiao-yan1; LING Zhi-fa2; YAN Zong-xun1; CHEN Min1; LI Ling1; PENG Yi-hua1; HUANG Xiao-jia1
Department of Endocrinology1,Department of Blood Transfusion2,Affiliated Hospital of North Sichuan Medical College, Nanchong 637000,Sichuan,China
关键词:
骨质疏松; 骨代谢标志物; 中老年女性
Keywords:
Key words：Osteoporosis; Bone metabolism markers; Middle-aged women
分类号:
R589.9
DOI:
10.3969/j.issn.1006-1959.2019.17.021
文献标志码:
A
摘要:
目的 分析骨代谢指标与骨质疏松的关系，为骨质疏松的防治提供流行病学依据。方法 采取随机分层抽样方法，选取2018年1月~5月来我院健康体检的30~90岁的成年女性400名。采用双能X线吸收测量仪（DEXA）测量腰椎及左侧股骨骨密度，由调查人员对所有体检对象进行问卷调查，同时收集清晨空腹血检测血常规、肝肾功、骨吸收指标TRAP-5b、CTX、 N-MID及骨形成指标BAP、PⅠNP等资料，进行统计学分析。结果 ①我院30岁以上女性骨质疏松的检出率为55.28%；②骨质疏松人群平均年龄为（63.54±9.40）岁，大于骨量减少人群的（49.42±9.51）岁和骨量正常人群的（44.14±6.71）岁，差异有统计学意义（P＜0.05）；年龄与骨密度存在相关性；③骨质疏松人群TRAP-5b、CTX、BAP水平大于骨量减少和骨量正常人群，均与骨密度存在相关性；N-MID、PⅠNP在骨质疏松人群、骨量减少和骨量正常人群中比较，差异无统计学意义（P＞0.05），与骨密度无相关性；④年龄升高是骨质疏松的危险因素，而超重和肥胖可能是骨质疏松的保护因素。⑤以年龄＞55岁来预测骨质疏松的敏感性和特异性分别为82.52%，81.48%；而以BAP＞17.7 μg/L来预测骨质疏松的敏感性和特异性分别为53.84%，73.65%。结论 中老年女性骨质疏松的检出率较高，年龄升高是骨质疏松的危险因素，骨密度与骨代谢指标TRAP-5b、CTX、BAP呈负相关。
Abstract:
Abstract：Objective Analysis of the relationship between bone metabolic markers and osteoporosis provides an epidemiological basis for the prevention and treatment of osteoporosis. Methods A randomized stratified sampling method was used to select 400 adult women aged 30-90 who were admitted to our hospital from January to May 2018. The dual-energy X-ray absorptiometry (DEXA) was used to measure the bone mineral density of the lumbar vertebrae and the left femur. The investigators conducted a questionnaire survey on all the subjects, and collected the early morning fasting blood test for blood routine, liver and kidney function, and bone resorption index TRAP-5b, CTX, N-MID and bone formation indicators BAP, PINP and other data for statistical analysis.Results ①The detection rate of osteoporosis in women over 30 years old in our hospital was 55.28%;②The average age of osteoporosis population was (63.54±9.40) years old, which was greater than that of people with reduced bone mass (49.42±9.51) years old and those with normal bone mass (44.14±6.71) years old, the difference was statistically significant (P<0.05). Age is related to bone mineral density; ③The levels of TRAP-5b, CTX and BAP in osteoporosis population were higher than those with normal bone mass and normal bone mass, and were associated with bone mineral density. N-MID and PINP were in osteoporosis population, bone mass loss and normal bone mass. There was no significant difference between the two groups (P>0.05) and no correlation with bone mineral density. ④Elevated age is a risk factor for osteoporosis, and overweight and obesity may be protective factors for osteoporosis. ⑤The sensitivity and specificity of predicting osteoporosis at age >55 years were 82.52% and 81.48%, respectively. The sensitivity and specificity of predicting osteoporosis with BAP>17.7μg/L were 53.84% and 73.65%, respectively.Conclusion The detection rate of osteoporosis is higher in middle-aged and elderly women. Age is a risk factor for osteoporosis. Bone mineral density is negatively correlated with bone metabolism markers TRAP-5b, CTX and BAP.

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更新日期/Last Update: 2019-09-01