[1]罗巧彦,凌止发,严宗逊,等.中老年女性骨代谢指标与骨质疏松的相关性研究[J].医学信息,2019,(17):68-71.[doi:10.3969/j.issn.1006-1959.2019.17.021]
 LUO Qiao-yan,LING Zhi-fa,YAN Zong-xun,et al.Correlation between Bone Metabolic Markers and Osteoporosis in Middle-aged and Elderly Women[J].Medical Information,2019,(17):68-71.[doi:10.3969/j.issn.1006-1959.2019.17.021]
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中老年女性骨代谢指标与骨质疏松的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年17期
页码:
68-71
栏目:
论著
出版日期:
2019-09-01

文章信息/Info

Title:
Correlation between Bone Metabolic Markers and Osteoporosis in Middle-aged and Elderly Women
文章编号:
1006-1959(2019)17-0068-04
作者:
罗巧彦1凌止发2严宗逊1陈 敏 1李 玲1彭乙华1黄晓佳1
川北医学院附属医院内分泌科1,输血科2,四川 南充 637000
Author(s):
LUO Qiao-yan1LING Zhi-fa2YAN Zong-xun1CHEN Min1LI Ling1PENG Yi-hua1HUANG Xiao-jia1
Department of Endocrinology1,Department of Blood Transfusion2,Affiliated Hospital of North Sichuan Medical College, Nanchong 637000,Sichuan,China
关键词:
骨质疏松骨代谢标志物中老年女性
Keywords:
Key words:OsteoporosisBone metabolism markersMiddle-aged women
分类号:
R589.9
DOI:
10.3969/j.issn.1006-1959.2019.17.021
文献标志码:
A
摘要:
目的 分析骨代谢指标与骨质疏松的关系,为骨质疏松的防治提供流行病学依据。方法 采取随机分层抽样方法,选取2018年1月~5月来我院健康体检的30~90岁的成年女性400名。采用双能X线吸收测量仪(DEXA)测量腰椎及左侧股骨骨密度,由调查人员对所有体检对象进行问卷调查,同时收集清晨空腹血检测血常规、肝肾功、骨吸收指标TRAP-5b、CTX、 N-MID及骨形成指标BAP、PⅠNP等资料,进行统计学分析。结果 ①我院30岁以上女性骨质疏松的检出率为55.28%;②骨质疏松人群平均年龄为(63.54±9.40)岁,大于骨量减少人群的(49.42±9.51)岁和骨量正常人群的(44.14±6.71)岁,差异有统计学意义(P<0.05);年龄与骨密度存在相关性;③骨质疏松人群TRAP-5b、CTX、BAP水平大于骨量减少和骨量正常人群,均与骨密度存在相关性;N-MID、PⅠNP在骨质疏松人群、骨量减少和骨量正常人群中比较,差异无统计学意义(P>0.05),与骨密度无相关性;④年龄升高是骨质疏松的危险因素,而超重和肥胖可能是骨质疏松的保护因素。⑤以年龄>55岁来预测骨质疏松的敏感性和特异性分别为82.52%,81.48%;而以BAP>17.7 μg/L来预测骨质疏松的敏感性和特异性分别为53.84%,73.65%。结论 中老年女性骨质疏松的检出率较高,年龄升高是骨质疏松的危险因素,骨密度与骨代谢指标TRAP-5b、CTX、BAP呈负相关。
Abstract:
Abstract:Objective Analysis of the relationship between bone metabolic markers and osteoporosis provides an epidemiological basis for the prevention and treatment of osteoporosis. Methods A randomized stratified sampling method was used to select 400 adult women aged 30-90 who were admitted to our hospital from January to May 2018. The dual-energy X-ray absorptiometry (DEXA) was used to measure the bone mineral density of the lumbar vertebrae and the left femur. The investigators conducted a questionnaire survey on all the subjects, and collected the early morning fasting blood test for blood routine, liver and kidney function, and bone resorption index TRAP-5b, CTX, N-MID and bone formation indicators BAP, PINP and other data for statistical analysis.Results ①The detection rate of osteoporosis in women over 30 years old in our hospital was 55.28%;②The average age of osteoporosis population was (63.54±9.40) years old, which was greater than that of people with reduced bone mass (49.42±9.51) years old and those with normal bone mass (44.14±6.71) years old, the difference was statistically significant (P<0.05). Age is related to bone mineral density; ③The levels of TRAP-5b, CTX and BAP in osteoporosis population were higher than those with normal bone mass and normal bone mass, and were associated with bone mineral density. N-MID and PINP were in osteoporosis population, bone mass loss and normal bone mass. There was no significant difference between the two groups (P>0.05) and no correlation with bone mineral density. ④Elevated age is a risk factor for osteoporosis, and overweight and obesity may be protective factors for osteoporosis. ⑤The sensitivity and specificity of predicting osteoporosis at age >55 years were 82.52% and 81.48%, respectively. The sensitivity and specificity of predicting osteoporosis with BAP>17.7μg/L were 53.84% and 73.65%, respectively.Conclusion The detection rate of osteoporosis is higher in middle-aged and elderly women. Age is a risk factor for osteoporosis. Bone mineral density is negatively correlated with bone metabolism markers TRAP-5b, CTX and BAP.

参考文献/References:

[1]夏维波,章振林,林华,等.原发性骨质疏松症诊疗指南(2017)[J].中国骨质疏松杂志,2019,25(3):281-309. [2]杨茜,赵心宇.体检人群体重指数与脂肪肝的调查分析[J].中西医结合心血管病电子杂志,2018,6(14):188. [3]Li C,Lv WH,Wang TT,et al.The study of prevalence of osteoporsis in 1088 medical workers[J].Chin J Osteopor,2015,21(10):1217-1220. [4]Li ZJ,Zhang Y,Gu QS,et al.Survey and analysis of prevalence rate and risk factors of senile osteoporotic fracture in Chengdu Wenjiang[J].Sich Medical Journal,2015,36(2):156-159. [5]Cheraghi P,Cheraghi Z,Bozorgmehr S.The Prevalence and risk factors of osteoporosis among the elderly in Hamadan province:A cross sectional study[J].Med J Islam Repub Iran,2018,11(32):111. [6]GU Li-yu,CHEN Lei,YANG Dan-hong.Awareness and Risk Factors Of osteoporosis among Elderly People in a Community in Shanghai[J].Chinese Primary Health Care,2019,33(1):27-30. [7]Manolagas SC.From estrogen-centric to aging and oxidative stress:a revised perspective of the pathogenesis of osteoporosis[J].Endocr Rev,2010,31(3):266-300. [8]Wheater G,Elshahaly M,Tuck SP,et al.The clinical utility of bone marker measurements in osteoporosis[J].J Transl Med,2013,11(1):201-214. [9]潘奇,陈黔,钱黎.绝经后骨质疏松症患者血清TRACP-5b、Hcy、BAP水平变化及诊断效能[J].山东医药,2017,57(35):58-60.

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更新日期/Last Update: 2019-09-01