[1]香植权,叶钟泰.外用重组人碱性成纤维细胞生长因子 在牙周炎中的应用效果[J].医学信息,2019,(17):83-86.[doi:10.3969/j.issn.1006-1959.2019.17.025]
 XIANG Zhi-Quan,YE Zhong-Tai.Application Effect of Topical Recombinant Human Basic Fibroblast Growth Factor in Periodontitis[J].Medical Information,2019,(17):83-86.[doi:10.3969/j.issn.1006-1959.2019.17.025]
点击复制

外用重组人碱性成纤维细胞生长因子 在牙周炎中的应用效果()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年17期
页码:
83-86
栏目:
论著
出版日期:
2019-09-01

文章信息/Info

Title:
Application Effect of Topical Recombinant Human Basic Fibroblast Growth Factor in Periodontitis
文章编号:
1006-1959(2019)17-0083-04
作者:
香植权叶钟泰
深圳市宝安区人民医院口腔科,广东 深圳 518000
Author(s):
XIANG Zhi-QuanYE Zhong-Tai
Department of Stomatology,Shenzhen Baoan District People's Hospital,Shenzhen 518000, Guangdong,China
关键词:
碱性成纤维细胞生长因子牙周炎龈沟出血指数牙周探诊深度临床附着丧失
Keywords:
Key words:Basic fibroblast growth factorPeriodontitisSulcus bleeding indexDepth of periodontal probingClinical attachment loss
分类号:
R781.4
DOI:
10.3969/j.issn.1006-1959.2019.17.025
文献标志码:
A
摘要:
目的 探究外用重组人碱性成纤维细胞生长因子(rh FGF)在牙周炎治疗中的应用效果。方法 选取2018年1月~2019年1月在我院就诊的牙周炎患者100例,随机分为对照组和观察组,每组50例。对照组采用基础疗法进行治疗,观察组在基础疗法的基础上给予外用重组人碱性成纤维细胞生长因子进行治疗。比较两组治疗后不同时间点的龈沟出血指数(SBI)、牙周探诊深度(PD)、临床附着丧失(CAL)、炎症因子和治疗有效率。结果 两组治疗3周、6周的SBI、PD和CAL与治疗前比较均有所改善,治疗6周的改善程度高于治疗3周,差异具有统计学意义(P<0.05);观察组治疗3周、6周的SBI、PD和CAL均优于对照组,差异具有统计学意义(P<0.05)。两组治疗3周、6周的IL-1β、IL-8和IL-17与治疗前比较均降低,治疗6周的IL-1β、IL-8和IL-17均低于治疗3周,差异具有统计学意义(P<0.05);观察组治疗3周、6周的IL-1β、IL-8和IL-17均低于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率高于对照组(90.00% vs 62.00%),差异具有统计学意义(P<0.05)。结论 rh FGF治疗牙周炎患者,能够改善龈沟出血指数,减少牙周探诊深度、临床附着丧失,减低炎性因子,提高牙周组织的愈合速度。
Abstract:
Abstract:Objective To explore the application of topical recombinant human basic fibroblast growth factor (rh FGF) in the treatment of periodontitis.Methods 100 patients with periodontitis who were treated in our hospital from January 2018 to January 2019 were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with basic therapy, and the observation group was treated with external recombinant human basic fibroblast growth factor on the basis of basic therapy. The sulcus bleeding index (SBI), periodontal probing depth (PD), clinical attachment loss (CAL), inflammatory factors, and treatment effectiveness were compared at different time points after treatment.Results The SBI, PD and CAL of the two groups were improved at 3 weeks and 6 weeks compared with those before treatment. The improvement rate after 6 weeks of treatment was higher than that of the treatment for 3 weeks, the difference was statistically significant (P<0.05). SBI, PD and CAL were better in the observation group than in the control group at 3 and 6 weeks,the difference was statistically significant (P<0.05). IL-1β, IL-8 and IL-17 were decreased in both groups at 3 and 6 weeks before treatment, and IL-1β, IL-8 and IL-17 were lower than treatment for 3 weeks after treatment for 6 weeks,the difference was statistically significant (P<0.05). The IL-1β, IL-8 and IL-17 levels in the observation group were lower than those in the control group at 3 and 6 weeks,the difference was statistically significant (P<0.05). The total effective rate of the observation group was higher than that of the control group (90.00% vs 62.00%),the difference was statistically significant (P<0.05).Conclusion rh FGF can improve the gingival bleeding index, reduce the depth of periodontal probing, clinical attachment loss, reduce inflammatory factors and improve the healing rate of periodontal tissue.

参考文献/References:

[1]兰倩,韩璐,孙昌娟,等.重组人碱性成纤维细胞生长因子在上颌磨牙Ⅱ度根分叉病变治疗中的作用[J].佛山科学技术学院学报(自然科学版),2016,34(6):61-64. [2]杨栋,李红梅,刘林花,等.Th17及其相关因子在不同牙周炎症状态龈沟液中的检测[J].口腔医学研究,2017,33(11):1161-1164. [3]毛小泉,郁豆,程亚楠,等.激光对炎症牙髓中碱性成纤维细胞生长因子表达的影响[J].中国组织工程研究,2014,18(46):7401-7405. [4]王新君,郭俊磊.重组牛碱性成纤维细胞生长因子凝胶联合基础疗法治疗牙龈炎的效果[J].中国民康医学,2019,31(6):83-84. [5]Wang YJ,Fan F,Li XM,et al.Influence of gingival retraction paste versus cord on periodontal health:a systematic review and meta-analysis[J].Quintessence International,2019,50(3):234-244. [6]Liaw A,Miller C,Nimmo A.Comparing the periodontal tissue response to non-surgical scaling and root planing alone,adjunctive azithromycin,or adjunctive amoxicillin plus metronidazole in generalized chronic moderate-to-severe periodontitis:a preliminary randomized controlled trial[J].Australian Dental Journal,2019,64(2):145-152. [7]孟琨.康复新液对口腔正畸所致慢性牙龈炎临床疗效及对牙龈肿胀及疼痛改善情况的影响[J].基因组学与应用生物学,2018,37(3):996-1001. [8]赵阳,贺晓,李雪梅,等.重组牛碱性成纤维细胞生长因子凝胶联合短波理疗仪治疗面部敏感性皮肤的疗效观察[J].中国皮肤性病学杂志,2018,32(9):1102-1106. [9]方会清,张子川,陈光.重组牛碱性成纤维细胞生长因子凝胶治疗干槽症的临床疗效观察[J].全科口腔医学电子杂志,2018,5(26):63-65. [10]张会选.重组牛碱性成纤维细胞生长因子联合牙周基础治疗牙龈炎的效果观察[J].河南医学研究,2018,27(20):3771-3772. [11]林洁,代志强.重组牛碱性成纤维细胞生长因子外用凝胶治疗局部烧烫伤的疗效观察[J].中国医药导刊,2014,16(6):1016-1017. [12]李小燕,聂磊,刘科峰.超脉冲CO2点阵激光联合重组牛碱性成纤维细胞生长因子凝胶治疗痤疮凹陷性瘢痕疗效观察[J].实用药物与临床,2018,21(1):58-60. [13]全知怎,陈盈哲,汪大林.重组牛碱性成纤维细胞生长因子外用凝胶用于舌癌术后放疗患者口腔溃疡的效果分析[J].实用癌症杂志,2018,33(1):163-165. [14]Zhou M,Liu NX,Zhang Q,et al.Effect of tetrahedral DNA nanostructures on proliferation and osteogenic differentiation of human periodontal ligament stem cells[J].Cell Proliferation,2019,52(3):126-129. [15]Agnes Schroder,Erika Calvano Küchler,Marjorie Omori,et al.Effects of ethanol on human periodontal ligament fibroblasts subjected to static compressive force[J].Alcohol,2019,77(21):59-70.

相似文献/References:

[1]赵 敏,杨长怡,郭晓倩,等.激光治疗中重度慢性牙周炎的临床效果评价[J].医学信息,2018,(05):93.[doi:10.3969/j.issn.1006-1959.2018.05.030]
 ZHAO Min,YANG Chang-yi,GUO Xiao-qian,et al.Clinical Evaluation of Laser Treatment for Moderate and Severe Chronic Periodontitis[J].Medical Information,2018,(17):93.[doi:10.3969/j.issn.1006-1959.2018.05.030]
[2]宋 佳,赵 刚,宋春蕾.骨碎补对牙周炎大鼠正畸牙移动保持阶段RANKL表达影响的研究[J].医学信息,2019,(04):85.[doi:10.3969/j.issn.1006-1959.2019.04.028]
 SONG Jia,ZHAO Gang,SONG Chun-lei.Effect of Drynaria on the Expression of RANKL in the Period of Orthodontic Tooth Movement in Rats with Periodontitis[J].Medical Information,2019,(17):85.[doi:10.3969/j.issn.1006-1959.2019.04.028]

更新日期/Last Update: 2019-09-01