[1]王洪峰.哮喘儿童发病与血液一氧化氮、肿瘤坏死因子变化的研究[J].医学信息,2019,32(17):107-108.[doi:10.3969/j.issn.1006-1959.2019.17.034]
　WANG Hong-feng.Study on the Incidence of Childhood Nitric Oxide and Tumor Necrosis Factor in Children with Asthma[J].Journal of Medical Information,2019,32(17):107-108.[doi:10.3969/j.issn.1006-1959.2019.17.034]
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哮喘儿童发病与血液一氧化氮、肿瘤坏死因子变化的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年17期
页码:
107-108
栏目:
临床研究
出版日期:
2019-09-01

文章信息/Info

Title:
Study on the Incidence of Childhood Nitric Oxide and Tumor Necrosis Factor in Children with Asthma
文章编号:
1006-1959（2019）17-0107-02
作者:
王洪峰
佳木斯市中心医院儿科，黑龙江 佳木斯 154002
Author(s):
WANG Hong-feng
Department of Pediatrics,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China
关键词:
哮喘儿童; 一氧化氮; 肿瘤坏死因子
Keywords:
Key words：Children with asthma; Nitric oxide; Tumor necrosis factor
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2019.17.034
文献标志码:
A
摘要:
目的 研究哮喘儿童发病与血液一氧化氮、肿瘤坏死因子变化。方法 选择2018年1月~2019年1月在我院诊治的哮喘儿童70例作为研究对象，依据病情分为缓解组和发作组，各35例，另选取同期在我院在体检健康儿童35例作为对照组。分别检测各组血液一氧化氮（NO）、肿瘤坏死因子水平，并分析NO、肿瘤坏死因子与哮喘儿童发病的关系。结果 发作组NO水平为（46.67±18.92）μmol/L、肿瘤坏死因子水平为（198.77±42.29）ng/L，均高于缓解组的（32.41±14.22）μmol/L、（192.42±37.83）ng/L和对照组（29.54±14.34）μmol/L、（164.51±31.11）ng/L，差异有统计学意义（P＜0.05）；缓解组NO、肿瘤坏死因子水平高于对照组，差异有统计学意义（P＜0.05）；哮喘组肿瘤坏死因子水平与NO水平呈正相关（r=0.36、0.48，P＜0.05）。结论 NO、肿瘤坏死因子参与哮喘发作期气道炎症的形成，肿瘤坏死因子水平与NO水平密切相关，肿瘤坏死因子可作为哮喘缓解期患儿炎症持续的重要指标，具有重要的临床研究意义。
Abstract:
Abstract：Objective To study the pathogenesis of children with asthma and changes of blood nitric oxide and tumor necrosis factor.Methods A total of 70 children with asthma who were treated in our hospital from January 2018 to January 2019 were enrolled in the study. According to the condition, they were divided into the remission group and the seizure group, 35 cases for each roupg, and another 35 cases of healthy children in our hospital during the same period as a control group. The levels of blood nitric oxide (NO) and tumor necrosis factor were measured in each group, and the relationship between NO, tumor necrosis factor and childhood asthma was analyzed.Results The level of NO in the seizure group was (46.67±18.92) μmol/L, and the level of tumor necrosis factor was (198.77±42.29) ng/L, which was higher than that in the remission group (32.41±14.22) μmol/L, (192.42±37.83) ng/ L and the control group (29.54±14.34) μmol/L, (164.51±31.11) ng/L, the difference was statistically significant (P<0.05); the NO and tumor necrosis factor levels in the remission group were higher than the control group, the difference was statistically significant(P<0.05); the level of tumor necrosis factor was positively correlated with NO level in asthma group(r=0.36,0.48,P<0.05).Conclusion NO and tumor necrosis factor are involved in the formation of airway inflammation during asthma attack. The level of tumor necrosis factor is closely related to the level of NO. Tumor necrosis factor can be used as an important indicator of inflammation persistence in children with asthma remission. It has important clinical significance.

参考文献/References:

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更新日期/Last Update: 2019-09-01