[1]高占群,李 霜,刘 杨.苯那普利联合阿托伐他汀治疗冠心病合并2型糖尿病 心功能不全的临床效果[J].医学信息,2019,(17):135-136,141.[doi:10.3969/j.issn.1006-1959.2019.17.044]
 GAO Zhan-qun,LI Shuang,LIU Yang.Clinical Effect of Benazepril Combined with Atorvastatin in the Treatment of Coronary Heart Disease Complicated with Type 2 Diabetes with Cardiac Insufficiency[J].Medical Information,2019,(17):135-136,141.[doi:10.3969/j.issn.1006-1959.2019.17.044]
点击复制

苯那普利联合阿托伐他汀治疗冠心病合并2型糖尿病 心功能不全的临床效果()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年17期
页码:
135-136,141
栏目:
药物与临床
出版日期:
2019-09-01

文章信息/Info

Title:
Clinical Effect of Benazepril Combined with Atorvastatin in the Treatment of Coronary Heart Disease Complicated with Type 2 Diabetes with Cardiac Insufficiency
文章编号:
1006-1959(2019)17-0135-03
作者:
高占群李 霜刘 杨
佳木斯大学附属第一医院心内科,黑龙江 佳木斯 154002
Author(s):
GAO Zhan-qunLI ShuangLIU Yang
Department of Cardiology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154002, Heilongjiang,China
关键词:
阿托伐他汀苯那普利冠心病2型糖尿病心功能不全
Keywords:
Key words:AtorvastatinBenazeprilCoronary heart diseaseType 2 diabetesCardiac insufficiency
分类号:
R541.4;R587.2
DOI:
10.3969/j.issn.1006-1959.2019.17.044
文献标志码:
A
摘要:
目的 分析苯那普利联合阿托伐他汀治疗冠心病合并2型糖尿病(T2DM)心功能不全患者的临床疗效。方法 选择我院2016年10月~2017年9月收治的70例冠心病合并T2DM心功能不全患者为研究对象,随机分为普通组与观察组,各35例,普通组患者行阿托伐他汀治疗,观察组在此基础上联合苯那普利治疗,比较两组患者空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)水平,左心室射血分数(LVEF)、左心室舒张末内径(LVEDD)及左心室收缩末内径(LVESD),随访1年观察两组不良事件发生情况。结果 观察组患者FBG、2hPG、HbA1c分别为(5.53±1.10)mmol/L、(7.79±1.12)mmol/L、(7.12±0.86)%,低于对照组的(6.87±1.54)mmol/L、(9.12±1.43)mmol/L、(8.04±1.01)%,差异有统计学意义(P<0.05);观察组LVEF水平高于普通组,LVEDD、LVESD低于普通组,差异有统计学意义(P<0.05);随访1年,观察组不良事件发生率为8.57%,低于普通组的25.71%,差异有统计学意义(P<0.05)。结论 苯那普利联合阿托伐他汀治疗冠心病合并T2DM心功能不全患者,临床疗效显著,可降低患者血糖水平,改善其心功能,减少不良事件的发生,应用效果较好。
Abstract:
Abstract:Objective To analyze the clinical efficacy of benazepril combined with atorvastatin in patients with coronary heart disease complicated with type 2 diabetes mellitus (T2DM).Methods 70 patients with coronary heart disease and T2DM cardiac dysfunction who were admitted to our hospital from October 2016 to September 2017 were randomly divided into the general group and the observation group, 35 cases each. The general group received atorvastatin treatment, the observation group was combined with benazepril on the basis of this, comparing fasting blood glucose (FBG), postprandial 2h blood glucose (2hPG), glycosylated hemoglobin (HbA1c) level, left ventricular ejection fraction (LVEF), left Ventricular end diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) were observed at 1 year follow-up.Results The FBG, 2hPG and HbA1c in the observation group were (5.53±1.10) mmol/L, (7.79±1.12) mmol/L, (7.12±0.86)%, which was lower than that of the control group (6.87±1.54) mmol/L, ( 9.12±1.43)mmol/L, (8.04±1.01)%, the difference was statistically significant (P<0.05); the LVEF level in the observation group was higher than that in the normal group, and the LVEDD and LVESD were lower than the normal group, the difference was statistically significant (P<0.05); After 1 year of follow-up, the incidence of adverse events was 8.57% in the observation group, which was lower than that in the normal group 25.71%,the difference was statistically significant (P<0.05).Conclusion Benazepril combined with atorvastatin in the treatment of patients with coronary heart disease and T2DM cardiac dysfunction has a significant clinical effect, which can reduce blood glucose levels, improve cardiac function, reduce adverse events, and have a good application effect.

参考文献/References:

[1]陈奇盛,张萍,梁慧.阿托伐他汀钙对中老年2型糖尿病合并冠心病的疗效分析[J].广西医科大学学报,2018,35(6):858-861. [2]黄彩念.依那普利联合阿托伐他汀钙胶囊治疗高血压并冠心病的临床疗效及安全性[J].吉林医学,2017,38(12):2306-2307. [3]薛强,苑媛,孙静,等.中西医结合治疗对T2DM合并CHD患者血糖、血脂及血管内皮功能的影响[J].现代生物医学进展,2017,17(32):6299-6303. [4]冀永春,王蕊.依那普利联合硝苯地平控释片对老年冠心病合并高血压患者的临床疗效研究[J].中国医学前沿杂志(电子版),2017,9(7):170-173. [5]李云超,刘晓静.依那普利联合美托洛尔对原发性高血压合并冠心病患者的临床疗效及应用价值[J].河北医药,2018,40(6):911-913,917. [6]刘燕,高莉.苯那普利联合替米沙坦治疗高血压的临床疗效及对动脉硬化的影响[J].中国慢性病预防与控制,2017,25(9):705-707. [7]高博文.联用硝苯地平与依那普利对老年冠心病合并高血压患者进行治疗的效果探究[J].当代医药论丛,2017,15(16):87-88. [8]胡姗姗,肖莉,胡菁,等.阿托伐他汀联合苯那普利治疗冠心病合并2型糖尿病心功能不全者56例疗效观察[J].中国临床医生杂志,2018,46(11):40-43.

相似文献/References:

[1]王 毅.阿托伐他汀联合曲美他嗪治疗冠心病的临床效果评价[J].医学信息,2018,(13):139.[doi:10.3969/j.issn.1006-1959.2018.13.041]
 WANG Yi.Clinical Evaluation of Atto Vastatin Combined with Trimetazidine in the Treatment of Coronary Atherosclerotic Heart Disease[J].Medical Information,2018,(17):139.[doi:10.3969/j.issn.1006-1959.2018.13.041]
[2]王润俊.阿托伐他汀改善蛛网膜下腔出血患者的预后分析[J].医学信息,2018,(14):142.[doi:10.3969/j.issn.1006-1959.2018.14.043]
 WANG Run-jun.Analysis of Atorvastatin Improves Prognosis in Patients with Subarachnoid Hemorrhage[J].Medical Information,2018,(17):142.[doi:10.3969/j.issn.1006-1959.2018.14.043]
[3]袁 敏,周袁成.阿托伐他汀联合抗血小板药治疗脑血栓患者的疗效及对 血小板参数的影响[J].医学信息,2018,(16):123.[doi:10.3969/j.issn.1006-1959.2018.16.038]
 YUAN Min,ZHOU Yuan-cheng.Effect of Atorvastatin Combined with Antiplatelet Drugs on Patients with Cerebral Thrombosis and its Influence on Platelet Parameters[J].Medical Information,2018,(17):123.[doi:10.3969/j.issn.1006-1959.2018.16.038]
[4]徐润鸿.血府逐瘀汤联合阿托伐他汀钙治疗急性脑梗死的临床观察[J].医学信息,2019,(05):165.[doi:10.3969/j.issn.1006-1959.2019.05.054]
 XU Run-hong.Clinical Observation on Treatment of Acute Cerebral Infarction with Xuefu Zhuyu Decoction Combined with Atorvastatin Calcium[J].Medical Information,2019,(17):165.[doi:10.3969/j.issn.1006-1959.2019.05.054]
[5]沈有录,卢红涛,刘维军.阿托伐他汀和瑞舒伐他汀对高海拔地区PCI患者血脂、炎症因子和血管内皮功能的影响[J].医学信息,2019,(06):67.[doi:10.3969/j.issn.1006-1959.2019.06.022]
 SHEN You-lu,LU Hong-tao,LIU Wei-jun.Effects of Atorvastatin and Rosuvastatin on Blood Lipids,Inflammatory Factors and Vascular Endothelial Function in Patients with High Altitude PCI[J].Medical Information,2019,(17):67.[doi:10.3969/j.issn.1006-1959.2019.06.022]
[6]陈志萍.阿托伐他汀联合低分子肝素治疗短暂性脑缺血临床疗效[J].医学信息,2019,(09):153.[doi:10.3969/j.issn.1006-1959.2019.09.051]
 CHEN Zhi-ping.Clinical Efficacy of Atorvastatin Combined with Low Molecular Weight Heparin in the Treatment of Transient Cerebral Ischemia[J].Medical Information,2019,(17):153.[doi:10.3969/j.issn.1006-1959.2019.09.051]
[7]安志卫,刘 娜,薛芳芳.阿托伐他汀联合硫酸氢氯吡格雷治疗脑血栓的效果观察[J].医学信息,2019,(17):148.[doi:10.3969/j.issn.1006-1959.2019.17.049]
 AN Zhi-wei,LIU Na,XUE Fang-fang.Effect of Atorvastatin Combined with Clopidogrel Hydrogen Sulfate on Cerebral Thrombosis[J].Medical Information,2019,(17):148.[doi:10.3969/j.issn.1006-1959.2019.17.049]

更新日期/Last Update: 2019-09-01