[1]安志卫,刘 娜,薛芳芳.阿托伐他汀联合硫酸氢氯吡格雷治疗脑血栓的效果观察[J].医学信息,2019,32(17):148-149.[doi:10.3969/j.issn.1006-1959.2019.17.049]
　AN Zhi-wei,LIU Na,XUE Fang-fang.Effect of Atorvastatin Combined with Clopidogrel Hydrogen Sulfate on Cerebral Thrombosis[J].Journal of Medical Information,2019,32(17):148-149.[doi:10.3969/j.issn.1006-1959.2019.17.049]
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阿托伐他汀联合硫酸氢氯吡格雷治疗脑血栓的效果观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年17期
页码:
148-149
栏目:
药物与临床
出版日期:
2019-09-01

文章信息/Info

Title:
Effect of Atorvastatin Combined with Clopidogrel Hydrogen Sulfate on Cerebral Thrombosis
文章编号:
1006-1959（2019）17-0148-02
作者:
安志卫; 刘 娜; 薛芳芳
新疆兵团第七师医院神经内科，新疆 奎屯 833200
Author(s):
AN Zhi-wei; LIU Na; XUE Fang-fang
Department of Neurology,Xinjiang Corps Seventh Division Hospital,Kuitun 833200, Xinjiang,China
关键词:
脑血栓; 阿托伐他汀; 抗血小板药物; 后遗症
Keywords:
Key words：Cerebral thrombosis; Atorvastatin; Antiplatelet drugs; Sequelae
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2019.17.049
文献标志码:
A
摘要:
目的 观察阿托伐他汀联合抗血小板药治疗脑血栓的临床效果。方法 选择我院2018年1月~2019年1月收治的脑血栓患者80例，随机分为对照组和观察组，各40例。对照组采用抗血小板药治疗，观察组在此基础上联合阿托伐他汀治疗，比较两组患者临床疗效、平均血小板体积、血小板黏附率、血小板计数及语言障碍、肢体功能障碍、静脉血栓等后遗症情况。结果 对照组平均血小板体积、血小板黏附率及血小板计数分别为（25.30±5.44）fl、（40.54±5.93）%、（310.23±9.84）×109/L，高于观察组的（11.52±2.11）fl、（32.35±4.12）%、（277.34±7.27）×109/L，差异均有统计学意义（P＜0.05）；对照组治疗总有效率为82.50%，低于观察组的95.00%，差异有统计学意义（P＜0.05）；对照组后遗症发生率为25.00%，高于观察组的7.50%，差异有统计学意义（P＜0.05）。结论 阿托伐他汀联合抗血小板药治疗脑血栓患者的效果显著，可减少后遗症，改善患者血液粘稠度，应用效果较好。
Abstract:
Abstract：Objective To observe the clinical effect of atorvastatin combined with antiplatelet drugs in the treatment of cerebral thrombosis.Methods 80 patients with cerebral thrombosis admitted to our hospital from January 2018 to January 2019 were randomly divided into control group and observation group, 40 cases each. The control group was treated with antiplatelet drugs. The observation group was treated with atorvastatin. The clinical efficacy, mean platelet volume, platelet adhesion rate, platelet count and language disorder, limb dysfunction, venous thrombosis and other sequelae were compared between the two groups.Results The mean platelet volume, platelet adhesion rate and platelet count of the control group were (25.30±5.44) fl, (40.54±5.93)%, (310.23±9.84)×109/L, which was higher than that of the observation group (11.52±2.11) fl. (32.35±4.12)%, (277.34±7.27)×109/L, the difference was statistically significant (P<0.05); the total effective rate of the control group was 82.50%, which was lower than the observation group's 95.00%,the difference was statistically significant (P<0.05); the incidence of sequelae in the control group was 25.00%, which was higher than 7.50% in the observation group,the difference was statistically significant (P<0.05).Conclusion The efficacy of atorvastatin combined with antiplatelet drugs in the treatment of patients with cerebral thrombosis is significant, which can reduce the sequelae and improve the blood viscosity of patients.

参考文献/References:

[1]廖伟数,严国山,陈华,等.阿托伐他汀联合抗血小板药治疗对脑血栓临床效果、血小板参数及预后分析[J].当代医学,2018,24(2):87-88. [2]陈勋.探讨阿托伐他汀联合抗血小板药治疗对脑血栓的效果、血小板参数及后遗症发生率的影响[J].中国实用医药,2018,13(25):1-3. [3]高学忠.阿托伐他汀联合抗血小板药治疗脑血栓患者的疗效分析及对血小板参数的影响[J]. 心血管病防治知识,2017(9):10-11. [4]章燕,隽红燕.阿托伐他汀联合抗血小板药治疗脑血栓患者的效果及对血小板参数的影响[J].中外医学研究,2018,16(3):30-31. [5]张玉芳,李红杰,刘欢.阿托伐他汀治疗对症状性颅内动脉狭窄微栓子经颅多普勒监测的影响[J].河北医药,2015,37(11):1635-1637.

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更新日期/Last Update: 2019-09-01