[1]李大千,蒋 云,梅燕萍.抗凝血酶Ⅲ、D-二聚体与纤维蛋白原在 下肢静脉血栓形成中的临床应用[J].医学信息,2019,32(17):167-169.[doi:10.3969/j.issn.1006-1959.2019.17.057]
　LI Da-qian,JIANG Yun,MEI Yan-ping.Clinical Application of Antithrombin III,D-dimer and Fibrinogen in Venous Thrombosis of Lower Extremity[J].Journal of Medical Information,2019,32(17):167-169.[doi:10.3969/j.issn.1006-1959.2019.17.057]
点击复制

抗凝血酶Ⅲ、D-二聚体与纤维蛋白原在 下肢静脉血栓形成中的临床应用()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年17期
页码:
167-169
栏目:
诊疗技术
出版日期:
2019-09-01

文章信息/Info

Title:
Clinical Application of Antithrombin III,D-dimer and Fibrinogen in Venous Thrombosis of Lower Extremity
文章编号:
1006-1959（2019）17-0167-03
作者:
李大千; 蒋 云; 梅燕萍
南京市第一医院检验科，江苏 南京 210006
Author(s):
LI Da-qian; JIANG Yun; MEI Yan-ping
Department of Clinical Laboratory,Nanjing First Hospital,Nanjing 210006,Jiangsu,China
关键词:
抗凝血酶Ⅲ; D-二聚体; 纤维蛋白原; 下肢静脉血栓
Keywords:
Key words：Antithrombin III; D-dimer; Fibrinogen; Lower extremity venous thrombosis
分类号:
R543.6
DOI:
10.3969/j.issn.1006-1959.2019.17.057
文献标志码:
A
摘要:
目的 探讨抗凝血酶Ⅲ（AT-Ⅲ）、D-二聚体（D-D）与纤维蛋白原（Fbg）对下肢静脉血栓形成的临床应用价值。方法 选取2018年1月~12月我院收治的下肢静脉血栓患者100例设为观察组，另选取同期100名健康体检者设为对照组。观察组给予什么治疗方法，比较两组AT-Ⅲ、D-D与Fbg变化及其对下肢静脉血栓的诊断率。结果 术前观察组AT-Ⅲ低于对照组[（82.82±9.17）% vs（101.4±7.66）%]，D-D与Fbg高于对照组[（23.49±14.82） g/mL vs（0.37±0.12） g/mL]、[（4.65±1.12）g/L vs（2.52±0.51）g/L]，差异有统计学意义（P＜0.05）。观察组术后6 d AT-Ⅲ高于术后3 d[（90.61±7.68）% vs（89.13±29.01）%]，但差异无统计学意义（P＞0.05）；D-D与Fbg低于术后3 d[（2.80±0.95） g/mL vs（12.35±8.01） g/mL]、[（2.75±1.01）g/L vs（3.58±1.07）g/L]，差异有统计学意义（P＜0.05）。三项联合检测对下肢静脉血栓的诊断率高于AT-Ⅲ、D-D和Fbg单项检测，差异有统计学意义（P＜0.05）。结论 检测AT-Ⅲ、D-D和Fbg是判断机体抗凝水平和血栓形成较为简便且快速的方法，可以作为下肢静脉血栓形成早期诊断与治疗的指标，且三项联合检测可提高下肢静脉血栓诊断率。
Abstract:
Abstract：Objective To investigate the clinical value of antithrombin III (AT-III), D-dimer (D-D) and fibrinogen (Fbg) in the treatment of lower extremity venous thrombosis.Methods 100 patients with lower extremity venous thrombosis admitted to our hospital from January to December 2018 were enrolled in the observation group. Another 100 healthy subjects were selected as the control group. What treatment methods were given by the observation group, and the changes of AT-III, D-D and Fbg and the diagnosis rate of venous thrombosis of the lower extremities were compared between the two groups.Results Before operation, the AT-III of the observation group was lower than the control group [(82.82±9.17)% vs (101.4±7.66)%], and the D-D and Fbg were higher than the control group [(23.49±14.82)μg/mL vs(0.37±0.12)g/mL], [(4.65±1.12) g/L vs (2.52±0.51) g/L], the difference was statistically significant (P<0.05). At 6 d after operation, AT-III was higher than that at 3 d after operation [(90.61±7.68)% vs (89.13±29.01)%], but the difference was not statistically significant (P>0.05); D-D and Fbg were lower than postoperative 3 d[(2.80±0.95)μg/mL vs(12.35±8.01)μg/mL], [(2.75±1.01)g/L vs(3.58±1.07)g/L], the difference was statistically significant (P<0.05). The diagnostic rate of the three joint tests for lower extremity venous thrombosis was higher than that of AT-III, D-D and Fbg,the difference was statistically significant (P<0.05).Conclusion Detection of AT-III, D-D and Fbg is a simple and rapid method for judging the body's anticoagulant level and thrombosis. It can be used as an early diagnosis and treatment index for lower extremity venous thrombosis, and three combined tests can improve the diagnosis rate of venous thrombosis of lower extremities.

参考文献/References:

[1]李荣,张月玲.下肢静脉血栓形成的治疗及护理[J].吉林医学,2014(14):3146. [2]张宪振,王建峰.D-二聚体与纤维蛋白原在下肢静脉血栓诊断中的应用价值[J].双足与保健,2018,27(17):25,198. [3]黄少坤.彩色多普勒超声诊断下肢静脉血栓的临床效果观察[J].吉林医学,2018,39(12):2324-2325. [4]Fuji T,Akagi M,Abe Y,et al.Incidence of venous thromboembolism and bleeding events in patients with lower extremity orthopedic surgery:a retrospective analysis of a Japanese healthcare database[J].J Orthop Surg Res,2017,12(1):55. [5]Drescher FS,Sirovich BE,Lee A,et al.Aspirin versus anticoagulation for prevention of venous thromboembolism major lower extremity orthopedic surgery:a systematic review and meta-analysis[J].J Hosp Med,2014,9(9):579-585. [6]朱月峰,岳明.双下肢直接法多层螺旋CT静脉造影术对外伤骨折下肢深静脉血栓的早期诊断[J].中国医学影像学杂志,2016(7):524. [7]曹秀珠,赵林芳,王雅萍,等.53例下肢静脉曲张造影患者在超声引导下置入留置针的护理[J].中华护理杂志,2017,52(11):1396-1398. [8]唐金凤,陈先春,刘婷,等.2型糖尿病患者血浆凝血因子Ⅴ、凝血因子Ⅷ和纤维蛋白原、抗凝血酶Ⅲ联合检测的临床应用价值[J].黑龙江医学,2015(2):144. [9]赵熹君,王虹.抗凝血酶Ⅲ检测与血黏度的关系[J].国际检验医学杂志,2016,37(11):1482-1483. [10]郭玉婷,付艳丽,孔涛.人抗凝血酶Ⅲ的临床应用研究[J].国际生物制品学杂志,2018,41(2):86-90. [11]吴辉,王满琴,章柏平,等.低分子肝素联合血必净注射液治疗创伤性弥散性血管内凝血疗效及安全性分析[J].临床军医杂志,2017,45(9):983-985. [12]杨勇,蔡明.高龄下肢骨折患者术后血栓预防中D-二聚体临界值的研究[J].同济大学学报(医学版),2015(1):83. [13]胡钦胜,沈彬,杨静,等.动态检测D-二聚体与血浆纤维蛋白原预测全髋置换术后下肢深静脉血栓的价值[J].中国骨与关节杂志,2013(3):133. [14]李晓娟,李铁威,张洋.纤维蛋白原在心血管疾病中的临床应用价值[J].中国循环杂志,2017,32(12):1240-1242. [15]彭捷,陈韡.D-体和抗凝血酶联合检测在弥散性血管内凝血诊断中的应用价值分析[J].临床合理用药杂志,2018,11(32):147-148. [16]王鸿利,王学峰.血栓病临床新技术[M].北京:人民军医出版社,2003.

相似文献/References:

[1]和珍珍,吴彦洪,刘艳,等.凝血指标测定对诊断胎盘早剥的价值分析[J].医学信息,2018,31(01):153.[doi:10.3969/j.issn.1006-1959.2018.01.060]
　HE Zhen-zhen,WU Yan-hong,LIU Yan,et al.Value Analysis of Coagulation Index in Diagnosing Placental Abruption[J].Journal of Medical Information,2018,31(17):153.[doi:10.3969/j.issn.1006-1959.2018.01.060]
[2]孙朝霞,曹显刚,赵 利,等.发热伴血小板减少综合征患者D-二聚体、心肌酶谱及肝酶谱的检测[J].医学信息,2018,31(03):85.[doi:10.3969/j.issn.1006-1959.2018.03.026]
　SUN Zhao-xia,CAO Xian-gang,ZHAO li,et al.Detection of D-Dimer,Myocardial and Liver Enzymes in Patients with Fever and Thrombocytopenia Syndrome[J].Journal of Medical Information,2018,31(17):85.[doi:10.3969/j.issn.1006-1959.2018.03.026]
[3]付云杰.肺癌患者血浆D-二聚体、NSE及CYFRA21-1联合检测的临床价值[J].医学信息,2018,31(23):161.[doi:10.3969/j.issn.1006-1959.2018.23.047]
　FU Yun-jie.Clinical Value of the Plasma D-dimer and Serum NSE,CYFRA21-1 Combined Detection in the Diagnosis of Lung Cancer[J].Journal of Medical Information,2018,31(17):161.[doi:10.3969/j.issn.1006-1959.2018.23.047]
[4]赵华莹,李运泽,韦天灵,等.肝硬化合并门静脉血栓形成的危险因素分析[J].医学信息,2019,32(03):86.[doi:10.3969/j.issn.1006-1959.2019.03.026]
　ZHAO Hua-ying,LI Yun-ze,WEI Tian-ling,et al.Analysis of Risk Factors for Cirrhotic Patients with Portal Vein Thrombosis[J].Journal of Medical Information,2019,32(17):86.[doi:10.3969/j.issn.1006-1959.2019.03.026]
[5]宫园园.LDL、Hcy、D-二聚体及颈动脉粥样硬化与急性缺血性脑卒中相关性研究[J].医学信息,2019,32(05):117.[doi:10.3969/j.issn.1006-1959.2019.05.036]
　GONG Yuan-yuan.Correlation between LDL,Hcy,D-dimer and Carotid Atherosclerosis and Acute Ischemic Stroke[J].Journal of Medical Information,2019,32(17):117.[doi:10.3969/j.issn.1006-1959.2019.05.036]
[6]祁 闻,赵 红,王龙胜,等.肺栓塞CTPA间接征象诊断价值分析及临床意义[J].医学信息,2019,32(08):88.[doi:10.3969/j.issn.1006-1959.2019.08.026]
　QI Wen,ZHAO Hong,WANG Long-sheng,et al.Diagnostic Value and Clinical Significance of CTPA indirect signs in Pulmonary Embolism[J].Journal of Medical Information,2019,32(17):88.[doi:10.3969/j.issn.1006-1959.2019.08.026]
[7]杜治国,何 龙,黄 进,等.下肢创伤骨折后静脉血栓栓塞症相关检测项目分析[J].医学信息,2019,32(10):64.[doi:10.3969/j.issn.1006-1959.2019.10.022]
　DU Zhi-guo,HE Long,HUANG Jin,et al.Analysis of Related Items of Venous Thromboembolism after Traumatic Fracture of Lower Extremity[J].Journal of Medical Information,2019,32(17):64.[doi:10.3969/j.issn.1006-1959.2019.10.022]
[8]龚嘉玮,朱旭日,徐 锋,等.化瘀定痛液联合低分子肝素治疗老年粗隆间骨折围手术期肿痛的效果[J].医学信息,2020,33(03):148.[doi:10.3969/j.issn.1006-1959.2020.03.048]
　GONG Jia-wei,ZHU Xu-ri,XU Feng,et al.Effect of Huayudingtong Liquid Combined with Low-molecular-weight Heparin on Perioperative Swelling and Pain in Elderly Intertrochanteric Fractures[J].Journal of Medical Information,2020,33(17):148.[doi:10.3969/j.issn.1006-1959.2020.03.048]
[9]阙禄辉.闭合性骨折后下肢DVT患者D-二聚体、纤维蛋白原与Caprini评分的相关性分析[J].医学信息,2020,33(04):101.[doi:10.3969/j.issn.1006-1959.2020.04.030]
　QUE Lu-hui.Correlation Analysis of D-Dimer,Fibrinogen and Caprini Score in Patients with Lower Extremity DVT After Closed Fracture[J].Journal of Medical Information,2020,33(17):101.[doi:10.3969/j.issn.1006-1959.2020.04.030]
[10]张 起,彭晓蓉,彭梦瑶.血清CA125、CA153、TSGF及血浆D-二聚体联合检测诊断乳腺癌的价值[J].医学信息,2020,33(12):91.[doi:10.3969/j.issn.1006-1959.2020.12.026]
　ZHANG Qi,PENG Xiao-rong,PENG Meng-yao.Diagnostic Value of Combined Detection of Serum CA125,CA153,TSGF and Plasma D-dimer in Breast Cancer[J].Journal of Medical Information,2020,33(17):91.[doi:10.3969/j.issn.1006-1959.2020.12.026]

更新日期/Last Update: 2019-09-01