[1]刘 亭,鞠 进.氨磷汀联合精准护理治疗口腔癌放疗的临床效果[J].医学信息,2019,32(17):182-184.[doi:10.3969/j.issn.1006-1959.2019.17.063]
　LIU Ting,JU Jin.Clinical Effect of Amifostine Combined with Precision Nursing in the Treatment of Oral Cancer Radiotherapy[J].Journal of Medical Information,2019,32(17):182-184.[doi:10.3969/j.issn.1006-1959.2019.17.063]
点击复制

氨磷汀联合精准护理治疗口腔癌放疗的临床效果()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年17期
页码:
182-184
栏目:
护理研究
出版日期:
2019-09-01

文章信息/Info

Title:
Clinical Effect of Amifostine Combined with Precision Nursing in the Treatment of Oral Cancer Radiotherapy
文章编号:
1006-1959（2019）17-0182-03
作者:
刘 亭; 鞠 进
重庆医科大学附属第一医院肿瘤科，重庆 400016
Author(s):
LIU Ting; JU Jin
Department of Oncology,the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016,China
关键词:
氨磷汀; 放疗; 口腔癌; 精准护理
Keywords:
Key words：Amifostine; Radiotherapy; Oral cancer; Precise care
分类号:
R473.5
DOI:
10.3969/j.issn.1006-1959.2019.17.063
文献标志码:
A
摘要:
目的 探讨氨磷汀联合精准护理治疗口腔癌放疗的效果。方法 选择2015年1月~2017年12月我院收治的口腔癌根治性放化疗患者104例，随机分为观察组（n=43）和对照组（n=52），两组患者均实施精准护理，观察组配合使用氨磷汀，对照组未使用。比较两组患者放射性口腔黏膜炎发生情况及氨磷汀的消化道反应情况。结果 观察组Ⅳ度放射性黏膜炎5例，愈合时间中位数为28 d，对照组Ⅳ度放射性黏膜炎12例，愈合时间中位数为35 d。观察组出现Ⅳ度黏膜炎比例更低，且愈合时间更快，差异均有统计学意义（P＜0.05）；观察组Ⅰ度消化道反应19例（44.19%）、Ⅱ度消化道反应10例（23.26%），对照组Ⅰ度消化道反应20例（38.46%）、Ⅱ度消化道反应11例（21.15%），两组均无Ⅳ度消化道反应出现，观察组Ⅰ~Ⅱ度消化道反应发生率高于对照组，但差异无统计学意义（P＞0.05）。结论 采用氨磷汀治疗口腔癌放疗患者的同时配合精准护理，降低了放射性口腔黏膜炎的发生率，缩短愈合时间，同时氨磷汀的消化道反应未影响患者的生活质量。
Abstract:
Abstract：Objective To explore the effect of amifostine combined with precision nursing on oral cancer radiotherapy.Methods A total of 104 patients with radical chemoradiotherapy for oral cancer admitted to our hospital from January 2015 to December 2017 were randomly divided into observation group (n=43) and control group (n=52), both groups of patients were treated with precision care, and the observation group was combined with amifostine. The control group was not used. The incidence of radioactive oral mucositis and the digestive tract reaction of amifostine were compared between the two groups.Results 5 patients with grade IV radiation mucositis were observed in the observation group. The median healing time was 28 d. In the control group, 12 patients with grade IV radiation mucositis had a median healing time of 35 d. In the observation group, the proportion of IV degree mucositis was lower, and the healing time was faster, the difference was statistically significant (P<0.05). In the observation group, 19 cases (44.19%) of grade I digestive tract reaction and 10 cases of grade II digestive tract reaction (23.26%), In the control group, there were 20 cases of digestive tract reaction (38.46%) and 11 cases of grade II digestive tract reaction (21.15%). There was no IV digestive tract reaction in both groups. The incidence of I-II degree digestive tract reaction in the observation group was higher than that in the control group, but the difference was not statistically significant (P>0.05).Conclusion The use of amifostine in the treatment of oral cancer patients with radiotherapy has reduced the incidence of radiation oral mucositis and shortened the healing time. At the same time, the digestive tract reaction of amifostine did not affect the quality of life of patients.

参考文献/References:

[1]程磊,吴海涛,陶磊,等.经下颌骨裂开外旋入路切除扁桃体癌术后组织缺损的修复[J].临床耳鼻咽喉头颈外科杂志,2017, 31(6):415-419. [2]孙翠,李丽,王栋梅,等.精准护理在神经外科多重耐药菌感染控制中的应用[J].医学信息,2016,29(36):57-60. [3]吴葛芬.鼻咽癌放化疗致口腔黏膜炎的综合护理[J].中西医结合护理,2017,3(2):101-103. [4]李娜.白血病化疗患者口腔黏膜炎的精细化优质化护理[J].河南外科学杂志,2016,22(3):138-139. [5]梁菜清.鼻咽癌日间放疗患者放射性口腔黏膜炎的护理效果[J].实用临床护理学电子杂志,2017,2(34):129,134. [6]洪熙.物理抗菌剂在老年留置胃管口腔护理中的应用观察[J].皮肤病与性病,2015(5):298-299. [7]潘宏铭,徐农.肿瘤内科诊治策略[M].上海:上海科学技术出版社,2002:428-429. [8]Brizel DM,Wasserman TH,Henke M,et al.Phase －Ⅲ randomized trial of amifostine as a radioprotector in head and neck cancer[J].J Clin Oncol,2000,18(19):3339-3345. [9]颜巧元．精准医疗背景下护理学科面临的挑战[J].护理研究,2016,30(30):3713-3716．

相似文献/References:

[1]王春城.放疗联合替莫唑胺在高级别脑胶质瘤患者中的疗效观察[J].医学信息,2019,32(03):160.[doi:10.3969/j.issn.1006-1959.2019.03.053]
　WANG Chun-cheng.Therapeutic Effect of Radiotherapy Combined with Temozolomide in Patients with High Grade Glioma[J].Journal of Medical Information,2019,32(17):160.[doi:10.3969/j.issn.1006-1959.2019.03.053]
[2]钟文静,战 鹏,朱晓峰,等.胸骨软骨肉瘤1例报告[J].医学信息,2019,32(15):191.[doi:10.3969/j.issn.1006-1959.2019.15.066]
[3]龚建忠,韦 燕,潘琦津,等.锌剂防治鼻咽癌同步放化疗患者放射性口咽炎的效果分析[J].医学信息,2019,32(17):63.[doi:10.3969/j.issn.1006-1959.2019.17.020]
　GONG Jian-zhong,WEI Yan,PAN Qi-jin,et al.Effect of Zinc on Prevention and Treatment of Radiation Oropharyngeal Mucositis in Patients with Nasopharyngeal Carcinoma Treated with Concurrent Chemoradiotherapy[J].Journal of Medical Information,2019,32(17):63.[doi:10.3969/j.issn.1006-1959.2019.17.020]
[4]杨 柳,余忠华.鼻咽癌放疗所致口腔黏膜反应的防治研究[J].医学信息,2020,33(05):56.[doi:10.3969/j.issn.1006-1959.2020.05.017]
　YANG Liu,YU Zhong-hua.Study on Prevention and Treatment of Oral Mucosa Reaction Caused by Nasopharyngeal Carcinoma Radiotherapy[J].Journal of Medical Information,2020,33(17):56.[doi:10.3969/j.issn.1006-1959.2020.05.017]
[5]郭 雪,石学军.替吉奥与卡培他滨同步放疗治疗复发性结直肠癌疗效与安全性的Meta分析[J].医学信息,2020,33(07):71.[doi:10.3969/j.issn.1006-1959.2020.07.021]
　GUO Xue,SHI Xue-jun.Meta-analysis of the Efficacy and Safety of Simultaneous Therapy of Tegafur and Capecitabine for Recurrent Colorectal Cancer[J].Journal of Medical Information,2020,33(17):71.[doi:10.3969/j.issn.1006-1959.2020.07.021]
[6]李 博.唑来膦酸联合放疗治疗恶性肿瘤骨转移患者的效果[J].医学信息,2020,33(09):138.[doi:10.3969/j.issn.1006-1959.2020.09.044]
　YU Shou-jie,JIA Qian.The Effect of Zoledronic Acid Combined with Radiotherapy in Patients with Bone Metastases from Malignant TumorsLI Bo[J].Journal of Medical Information,2020,33(17):138.[doi:10.3969/j.issn.1006-1959.2020.09.044]
[7]钱晓芳,王舒蓓,竺 铭,等.品管圈活动对提高放射治疗科工作效率的效果[J].医学信息,2020,33(09):165.[doi:10.3969/j.issn.1006-1959.2020.09.055]
　QIAN Xiao-fang,WANG Shu-bei,ZHU Ming,et al.Effect of Quality Control Circle Activities on Improving the Efficiency of Radiotherapy Department[J].Journal of Medical Information,2020,33(17):165.[doi:10.3969/j.issn.1006-1959.2020.09.055]
[8]刘安东,刘崇华,王园园.参麦注射液联合放射治疗对中晚期食管癌老年患者的疗效[J].医学信息,2020,33(16):152.[doi:10.3969/j.issn.1006-1959.2020.16.048]
　LIU An-dong,LIU Chong-hua,WANG Yuan-yuan.The Effect of Shenmai Injection Combined with Radiotherapy on Elderly Patients with Advanced Esophageal Cancer[J].Journal of Medical Information,2020,33(17):152.[doi:10.3969/j.issn.1006-1959.2020.16.048]
[9]李 杨,吴舒鑫.放疗CT增强定位时护士接针时机引起的误差分析[J].医学信息,2020,33(17):173.[doi:10.3969/j.issn.1006-1959.2020.17.053]
　LI Yang,WU Shu-xin.Analysis of Errors Caused by Nurses’ Needle Timing During Radiotherapy with Enhanced CT Positioning[J].Journal of Medical Information,2020,33(17):173.[doi:10.3969/j.issn.1006-1959.2020.17.053]
[10]罗艳红,张 颖,郑春艳,等.沙利度胺预防宫颈癌放疗所致急性放射性肠炎的效果及对IL-6水平的影响[J].医学信息,2020,33(21):143.[doi:10.3969/j.issn.1006-1959.2020.21.044]
　LUO Yan-hong,ZHANG Ying,ZHENG Chun-yan,et al.The Effect of Thalidomide in Preventing Acute Radiation Enteritis Caused by Radiotherapy of Cervical Cancer and Its Effect on IL-6 Level[J].Journal of Medical Information,2020,33(17):143.[doi:10.3969/j.issn.1006-1959.2020.21.044]

更新日期/Last Update: 2019-09-01