[1]刘 杰.静脉注射利福平治疗老年肺结核的疗效[J].医学信息,2019,(18):142-143.[doi:10.3969/j.issn.1006-1959.2019.18.048]
 LIU Jie.Efficacy of Intravenous Rifampicin in the Treatment of Senile Pulmonary Tuberculosis[J].Medical Information,2019,(18):142-143.[doi:10.3969/j.issn.1006-1959.2019.18.048]
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静脉注射利福平治疗老年肺结核的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年18期
页码:
142-143
栏目:
药物与临床
出版日期:
2019-09-15

文章信息/Info

Title:
Efficacy of Intravenous Rifampicin in the Treatment of Senile Pulmonary Tuberculosis
文章编号:
1006-1959(2019)18-0142-02
作者:
刘 杰
佳木斯市肿瘤结核医院结核内一科,黑龙江 佳木斯 154007
Author(s):
LIU Jie
Department of Tuberculosis,Subject One,Cancer Tuberculosis Hospital,Jiamusi 154007,Heilongjiang,China
关键词:
静脉注射利福平老年人肺结核炎症因子
Keywords:
Key words:Intravenous injectionRifampicinElderlyTuberculosisInflammatory factors
分类号:
R521
DOI:
10.3969/j.issn.1006-1959.2019.18.048
文献标志码:
A
摘要:
目的 探讨静脉注射利福平联合抗结核药物治疗老年肺结核的疗效及对患者血清炎症因子水平的影响。方法 选取2016年3月~2017年4月我院收治的66例老年肺结核患者,采用随机数表法分为对照组和观察组,各33例。对照组在常规抗结核治疗基础上给予以口服利福平治疗,观察组在常规抗结核治疗基础上予以静脉注射利福平治疗。比较两组不同时间段痰菌阴转率、临床疗效、血清炎症因子水平。结果 观察组治疗后第1个月、3个月、6个月的痰菌阴转率分别为36.36%、63.64%、93.94%,均高于对照组15.15%、36.36%、72.73%(P<0.05);观察组临床总有效率为93.94%,高于对照组72.73%(P<0.05);治疗后,观察组血清TNF-α、IL-6、IL-10水平均低于对照组(P<0.05)。结论 静脉注射利福平可提高老年肺结核患者痰菌阴转率,降低血清炎症因子,提高临床疗效。
Abstract:
Abstract:Objective To investigate the efficacy of intravenous rifampicin combined with anti-tuberculosis drugs in the treatment of senile pulmonary tuberculosis and its effect on serum inflammatory factor levels.Methods 66 elderly patients with pulmonary tuberculosis admitted to our hospital from March 2016 to April 2017 were randomly divided into the control group and the observation group, with 33 cases in each group. The control group was treated with oral rifampicin on the basis of conventional anti-tuberculosis treatment, and the observation group was given intravenous rifampicin on the basis of conventional anti-tuberculosis treatment. The sputum negative conversion rate, clinical efficacy and serum inflammatory factor levels were compared between the two groups.Results The negative conversion rates of sputum in the observation group were 36.36%, 63.64% and 93.94% at the first month, 3 months and 6 months after treatment, respectively, which were higher than the control group 15.15%, 36.36% and 72.73%(P<0.05). The total effective rate of the observation group was 93.94%, which was higher than that of the control group 72.73%(P<0.05). After treatment,The levels of serum TNF-α, IL-6 and IL-10 in the observation group were lower than those in the control group(P<0.05).Conclusion Intravenous rifampicin can improve the rate of sputum negative conversion, reduce serum inflammatory factors and improve clinical efficacy in elderly patients with pulmonary tuberculosis.

参考文献/References:

[1]吴妍,李琦.老年肺结核的诊治现状与进展[J].中国防痨杂志,2016,37(1):60-63. [2]中华医学会结核病学分会.肺结核诊断和治疗指南[J].中华结核和呼吸杂志,2001,24(2):71-74. [3]周卫刚,迪力夏提·艾尼瓦尔.临床如何合理使用利福平注射液的探讨[J].临床肺科杂志,2016,21(6):1145-1147. [4]朱喜增,翟玉峰.静脉注射利福平治疗老年肺结核患者的疗效及对机体免疫的影响[J].中国老年学杂志,2015,35(6):1559-1561. [5]梁伊乐.利福平静脉注射对老年肺结核患者的临床疗效观察[J].中国现代药物应用,2016,10(3):126-127.

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更新日期/Last Update: 2019-09-15