[1]韩丽丽.甘精胰岛素与格列美脲联合治疗口服降糖药控制不佳 2型糖尿病的疗效[J].医学信息,2019,32(18):146-148.[doi:10.3969/j.issn.1006-1959.2019.18.050]
　HAN Lili.Therapeutic Effect of Insulin Glargine Combined with Glimepiride on Oral Hypoglycemic Agents for Poor Control of Type 2 Diabetes[J].Journal of Medical Information,2019,32(18):146-148.[doi:10.3969/j.issn.1006-1959.2019.18.050]
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甘精胰岛素与格列美脲联合治疗口服降糖药控制不佳 2型糖尿病的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年18期
页码:
146-148
栏目:
药物与临床
出版日期:
2019-09-15

文章信息/Info

Title:
Therapeutic Effect of Insulin Glargine Combined with Glimepiride on Oral Hypoglycemic Agents for Poor Control of Type 2 Diabetes
文章编号:
1006-1959（2019）18-0146-03
作者:
韩丽丽
首都医科大学石景山教学医院药剂科，北京 100043
Author(s):
HAN Lili
Department of Pharmacy,Shijingshan Teaching Hospital,Capital Medical University,Beijing 100043,China
关键词:
甘精胰岛素; 格列美脲; 2型糖尿病
Keywords:
Key words：Insulin glargine; Glimepiride; Type 2 diabetes
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2019.18.050
文献标志码:
A
摘要:
目的 观察甘精胰岛素与格列美脲联合治疗口服降糖药控制不佳2型糖尿病的疗效。方法 选择2018年6月~2019年3月在我院诊治的90例口服降糖药控制不佳2型糖尿病患者作为研究对象，随机分为对照组和观察组，各45例，对照组采用格列美脲治疗，观察组在对照组基础上联合甘精胰岛素治疗，对比两组临床治疗疗效、空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbA1c）水平以及低血糖发生情况。结果 治疗后，观察组治疗总有效率（93.33%）与对照组治疗总有效率（91.11%）比较，差异无统计学意义（P＞0.05）。治疗后两组FPG、2hPG、HbA1c水平均较治疗前降低，差异有统计学意义（P＜0.05）；观察组FPG、2hPG与对照组比较，差异无统计学意义（P＞0.05）；观察组HbA1c与对照组比较，差异有统计学意义（P＜0.05）；观察组低血糖发生率（17.78%）低于对照组（35.56%），差异有统计学意义（P＜0.05）。结论 口服降糖药控制不佳2型糖尿病患者采用甘精胰岛素联合格列美脲治疗疗效理想，且可降低治疗期间低血糖发生率，安全性高，值得临床应用。
Abstract:
Abstract：Objective To observe the efficacy of insulin glargine combined with glimepiride in the treatment of poorly controlled type 2 diabetes mellitus with oral hypoglycemic agents. Methods 90 patients with poor control of type 2 diabetes mellitus who were treated with oral hypoglycemic agents in our hospital from June 2018 to March 2019 were randomly divided into control group and observation group, 45 cases in each group. After urea treatment, the observation group was treated with insulin glargine on the basis of the control group. The clinical treatment efficacy, fasting blood glucose (FPG), postprandial 2h blood glucose (2hPG), glycosylated hemoglobin (HbA1c) level and hypoglycemia were observed.Results After treatment, the total effective rate of the observation group (93.33%) was compared with the total effective rate of the control group (91.11%),the difference was not statistically significant (P>0.05). After treatment, the levels of FPG, 2hPG and HbA1c in the two groups were lower than those before treatment,the difference was statistically significant (P<0.05). There was no significant difference between the observation group FPG and 2hPG and the control group (P>0.05).Compared with the control group, the difference of HbA1c in the observation group was statistically significant (P<0.05).The incidence of hypoglycemia in the observation group was(17.78%) lower than that in the control group( 35.56%),the difference was statistically significant (P<0.05).Conclusion Oral hypoglycemic agents have poor control of type 2 diabetes patients. The combination of insulin glargine and glimepiride is effective, and can reduce the incidence of hypoglycemia during treatment. It has high clinical safety and has important clinical application.

参考文献/References:

[1]董敬坚,甘利明.甘精胰岛素与格列美脲联合治疗口服降糖药控制不佳2型糖尿病的疗效[J].中国老年学杂志,2014(12):2892-2893. [2]于海英,刘畅,王福青,等.两种联合用药方案治疗2型糖尿病的疗效[J].中国老年学杂志,2015,31(15):2864-2865. [3]王丹,杨玉芝,冯琨.2型糖尿病患者口服药失效应用不同剂型胰岛素联合格列美脲的疗效比较[J].黑龙江医学,2014,36(6):401-403. [4]韩春生.甘精胰岛素和诺和灵N分别与格列美脲联合治疗2型糖尿病疗效比较[J].中国实用医药,2016,3(12):80-83. [5]卢防,魏爱生,陈苹.甘精胰岛素联合那格列奈与胰岛素泵对2型糖尿病骨折患者围手术期的疗效观察[J].中华内分泌代谢杂志,2014,26(2):127-129.

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更新日期/Last Update: 2019-09-15