[1]徐应朋,陈岩召.氨甲环酸对老年稳定型股骨粗隆间骨折围术期失血量影响[J].医学信息,2019,(05):148-150.[doi:10.3969/j.issn.1006-1959.2019.05.047]
 XU Ying-peng,CHEN Yan-zhao.Effect of Tranexamic Acid on Perioperative Blood Loss in Elderly Patients with Stable Intertrochanteric Fracture[J].Medical Information,2019,(05):148-150.[doi:10.3969/j.issn.1006-1959.2019.05.047]
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氨甲环酸对老年稳定型股骨粗隆间骨折围术期失血量影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年05期
页码:
148-150
栏目:
药物与临床
出版日期:
2019-03-01

文章信息/Info

Title:
Effect of Tranexamic Acid on Perioperative Blood Loss in Elderly Patients with Stable Intertrochanteric Fracture
文章编号:
1006-1959(2019)05-0148-03
作者:
徐应朋1陈岩召2
(1.湖北中医药大学,湖北 武汉 430065;2.中国人民解放军中部战区总医院骨科,湖北 武汉 430000)
Author(s):
XU Ying-peng1CHEN Yan-zhao2
(1.Hubei University of Chinese Medicine,Wuhan 430065,Hubei,China;2.Orthopedics Department,Central Theater Command General Hospital of the Chinese People’s Liberation Army,Wuhan 430000, Hubei,China)
关键词:
氨甲环酸股骨粗隆间骨折DHS失血
Keywords:
Tranexamic acidFemoral intertrochanteric fractureDHSBlood loss
分类号:
R687.3
DOI:
10.3969/j.issn.1006-1959.2019.05.047
文献标志码:
A
摘要:
目的 评价术前静脉使用氨甲环酸(TXA)对老年稳定型股骨粗隆间骨折患者行动力髋螺钉(DHS)内固定围手术期失血量的影响。方法 回顾性分析2015年1月1日~2018年12月1日因股骨粗隆间骨折在中国人民解放军中部战区总医院骨科行DHS内固定的老年患者90例,根据患者围手术期是否使用TXA分为两组。对照组45例,术前术后均未给予TXA;实验组45例,术前15 min静脉滴注TXA 20 mg/kg。记录患者术前及术后第1、3、5天血红蛋白、红细胞压积、凝血功能,比较两组隐性失血量、显性失血量、围手术期总失血量、输血率,记录血栓性并发症发生情况。结果 实验组围手术期总失血量、隐性失血量、显性失血量分别为(614.42±62.92)ml、(149.74±59.23)ml、(465.32±96.33)ml,低于对照组的(844.81±75.51)ml、(187.72±83.13)ml、(657.63±83.61)ml,差异有统计学意义(P<0.05)。实验组输血率为33.33%,低于对照组的60.00%,差异有统计学意义(P<0.05)。两组患者术后均未出现肺栓塞及下肢深静脉血栓形成。结论 术前使用TXA可以减少DHS治疗股骨粗隆间骨折围手术期失血量和输血率,且不增加术后深静脉血栓风险。
Abstract:
Objective To evaluate the effect of preoperative intravenous tranexamic acid (TXA) on perioperative blood loss in patients with stable intertrochanteric fractures of the aged with mobility-hose screw (DHS). Methods A retrospective analysis of 90 elderly patients who underwent DHS in the Department of Orthopaedics of the Central Hospital of the Central People’s Liberation Army from January 1, 2015 to December 1, 2018, according to whether the patient used TXA during the perioperative period. Divided into two groups. In the control group, 45 patients were not given TXA before and after operation. In the experimental group, 45 patients received intravenous infusion of TXA 20 mg/kg 15 min before surgery. The patients were recorded for hemoglobin, hematocrit and coagulation function before and 1st, 3rd and 5th day after operation. The hidden blood loss, dominant blood loss, total perioperative blood loss and blood transfusion rate were recorded. The thrombotic concurrency was recorded. The occurrence of the disease. Results The total perioperative blood loss, recessive blood loss and dominant blood loss of the experimental group were (614.42±62.92) ml, (149.74±59.23) ml, (465.32±96.33) ml, which was lower than that of the control group (844.81±75.51) ml, (187.72±83.13) ml, (657.63±83.61) ml, the difference was statistically significant (P<0.05). The blood transfusion rate of the experimental group was 33.33%, which was lower than that of the control group 60.00%,the difference was statistically significant (P<0.05). There were no pulmonary embolism and deep venous thrombosis of the lower extremities in both groups. Conclusion Preoperative TXA can reduce the perioperative blood loss and blood transfusion rate of DHS in the treatment of intertrochanteric fractures without increasing the risk of postoperative deep vein thrombosis.

参考文献/References:


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更新日期/Last Update: 2019-03-01