[1]王芳芳,吴晓翠.尼莫地平对脑出血患者局部脑血流、脑水肿及不同时间用药临床变化的影响[J].医学信息,2019,(05):158-159.[doi:10.3969/j.issn.1006-1959.2019.05.051]
 WANG Fang-fang,WU Xiao-cui.Effects of Nimodipine on Regional Cerebral Blood Flow,Brain Edema and Clinical Changes in Patients with Cerebral Hemorrhage[J].Medical Information,2019,(05):158-159.[doi:10.3969/j.issn.1006-1959.2019.05.051]
点击复制

尼莫地平对脑出血患者局部脑血流、脑水肿及不同时间用药临床变化的影响()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年05期
页码:
158-159
栏目:
药物与临床
出版日期:
2019-03-01

文章信息/Info

Title:
Effects of Nimodipine on Regional Cerebral Blood Flow,Brain Edema and Clinical Changes in Patients with Cerebral Hemorrhage
文章编号:
1006-1959(2019)05-0158-02
作者:
王芳芳吴晓翠
(天津市津南区咸水沽医院神经内科,天津 300350)
Author(s):
WANG Fang-fangWU Xiao-cui
(Department of Neurology,Xianshuigu Hospital,Jinnan District,Tianjin 300350,China)
关键词:
尼莫地平脑出血脑水肿临床变化
Keywords:
NimodipineCerebral hemorrhageBrain edemaClinical changes
分类号:
R473.34
DOI:
10.3969/j.issn.1006-1959.2019.05.051
文献标志码:
A
摘要:
目的 研究尼莫地平不同时间用药对脑出血患者局部脑血流、脑水肿及临床变化的影响。方法 选取2017年4月~2018年4月在我院诊治的96例脑出血患者,将其随机分为4组,A组为发病24 h内给予尼莫地平治疗(对照组),B组发病24~48 h给药、C组发病48~72 h给药、D组发病72 h后给药,比较各组治疗后局部水肿体积、神经功能缺损评分、生活能力评分等改善情况。结果 与对照组对比,随着给药时间推移,病灶水肿体积、神经功能缺损评分、缺血体积等指标逐渐增加,而生活能力评分逐渐降低,差异有统计学意义(P<0.05)。给药时间越早,尼莫地平对脑血流、脑水肿的改善效果越好,其差异显著(P<0.05)。结论 对于脑出血患者采用尼莫地平治疗,可以改善局部血流、脑水肿状况,减轻神经功能缺损,且24 h内用药治疗可以获得更加的疗效和预后效果。
Abstract:
Objective To investigate the effects of nimodipine at different times on regional cerebral blood flow, brain edema and clinical changes in patients with cerebral hemorrhage. Methods 96 patients with cerebral hemorrhage diagnosed in our hospital from April 2017 to April 2018 were randomly divided into 4 groups. Group A (control group)was treated with nimodipine within 24 h after onset, and group B was affected for 24 to 48 h. The drug was administered in group C for 48-72 h, and group D administered 72 h after onse. The improvement of local edema volume, neurological deficit score, and life ability score after treatment were compared. Results Compared with the control group, the lesion edema volume, neurological deficit score, ischemic volume and other indicators gradually increased with the administration time, while the life ability score gradually decreased, the difference was statistically significant (P<0.05). The earlier the administration time, the better the effect of nimodipine on cerebral blood flow and cerebral edema, and the difference was significant (P<0.05). Conclusion Nimodipine treatment for patients with cerebral hemorrhage can improve local blood flow, cerebral edema and reduce neurological deficits, and more effective and prognostic effects can be obtained within 24 h.

参考文献/References:


[1]杨鹤云,杨正宇,张红莲,等.尼莫地平对高血压脑出血患者脑血肿、水肿及神经功能恢复的影响[J].中国医药科学,2015(1):121-123.
[2]刘艳,熊瑛,刘志广.不同降压药物对高血压脑出血患者血肿体积及神经功能恢复的影响[J].中国实用神经疾病杂志,2014, 17(7):8-10.
[3]吴樵,蔡艺灵,杜娟,等.尼莫地平联合益脑脉胶囊在高血压性脑出血中的应用研究[J].现代生物医学进展,2012,12(36):7018-7020.
[4]李凡强.探讨尼莫地平注射液治疗急性高血压性脑出血及控制继发性再出血的临床效果[J].转化医学电子杂志,2016,3(6):47-48.
[5]张月华.尼莫地平对高血压脑出血患者脑血流动力学参数的改善作用[J].中国老年学杂志,2012,32(14):3092.

相似文献/References:

[1]杨立翠.优质护理应用于脑出血手术患者的效果观察[J].医学信息,2018,(01):165.[doi:10.3969/j.issn.1006-1959.2018.01.065]
 YANG Li-cui.Observation of the Effect of High Quality Nursing on Patients with Cerebral Hemorrhage[J].Medical Information,2018,(05):165.[doi:10.3969/j.issn.1006-1959.2018.01.065]
[2]周井铎,王旭飞,田康爱.脑出血与应激性高血糖的关系及处理[J].医学信息,2018,(05):7.[doi:10.3969/j.issn.1006-1959.2018.05.003]
 ZHOU Jing-duo,WANG Xu-fei,TIAN Kang-ai.Relationship between Intracerebral Hemorrhage and Stress Hyperglycemia and its Management[J].Medical Information,2018,(05):7.[doi:10.3969/j.issn.1006-1959.2018.05.003]
[3]孙 志,邢效如,揣兰香,等.青年脑出血患者的临床特点及发病危险因素分析[J].医学信息,2018,(06):80.[doi:10.3969/j.issn.1006-1959.2018.06.025]
 SUN Zhi,XING Xiao-ru,CHUAI Lan-xiang,et al.Analysis of Clinical Features and Risk Factors of Cerebral Hemorrhage in Youth[J].Medical Information,2018,(05):80.[doi:10.3969/j.issn.1006-1959.2018.06.025]
[4]周 涛.含膳食纤维肠内营养在脑出血术后患者中的价值分析[J].医学信息,2018,(10):111.[doi:10.3969/j.issn.1006-1959.2018.10.035]
 ZHOU Tao.Analysis of the Value of Dietary Fiber Enteral Nutrition in Postoperative Patients with Cerebral Hemorrhage[J].Medical Information,2018,(05):111.[doi:10.3969/j.issn.1006-1959.2018.10.035]
[5]张旦旦.早期康复护理对脑出血吞咽障碍患者康复的应用效果观察[J].医学信息,2018,(17):173.[doi:10.3969/j.issn.1006-1959.2018.17.055]
 ZHANG Dan-dan.Observation on the Effect of Early Rehabilitation Nursing on Rehabilitation of Patients with Cerebral Hemorrhage and Deglutition Disorders[J].Medical Information,2018,(05):173.[doi:10.3969/j.issn.1006-1959.2018.17.055]
[6]赵文斌,张银善,张大春,等.早期气管切开术在颅脑外伤和脑出血治疗中的效果观察[J].医学信息,2018,(18):80.[doi:10.3969/j.issn.1006-1959.2018.18.024]
 ZHAO Wen-bin,ZHANG Yin-shan,ZHANG Da-chun,et al.Effect of Early Tracheotomy on the Treatment of Craniocerebral Trauma and Cerebral Hemorrhage[J].Medical Information,2018,(05):80.[doi:10.3969/j.issn.1006-1959.2018.18.024]
[7]彭莹萍.尼莫地平与盐酸氟桂利嗪治疗老年偏头痛的临床疗效观察[J].医学信息,2018,(22):150.[doi:10.3969/j.issn.1006-1959.2018.22.044]
 PENG Ying-ping.Clinical Efficacy of Nimodipine and Flunarizine Hydrochloride in the Treatment of Senile Migraine[J].Medical Information,2018,(05):150.[doi:10.3969/j.issn.1006-1959.2018.22.044]

更新日期/Last Update: 2019-03-01