[1]卜易莹,韩东兴,刘邦令,等.血清miR-145表达与乳腺癌患者的相关性分析[J].医学信息,2019,(07):5-7.[doi:10.3969/j.issn.1006-1959.2019.07.002]
 BU Yi-ying,HAN Dong-xing,LIU Bang-ling,et al.Correlation Analysis between Serum miR-145 Expression and Breast Cancer Patients[J].Medical Information,2019,(07):5-7.[doi:10.3969/j.issn.1006-1959.2019.07.002]
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血清miR-145表达与乳腺癌患者的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年07期
页码:
5-7
栏目:
乳腺癌专题
出版日期:
2019-04-01

文章信息/Info

Title:
Correlation Analysis between Serum miR-145 Expression and Breast Cancer Patients
文章编号:
1006-1959(2019)07-0005-03
作者:
卜易莹1韩东兴1刘邦令1姚 露1刘少扬2
(1.上海市建工医院乳腺外科,上海 200080;2.上海市普陀区中心医院骨科,上海 200333)
Author(s):
BU Yi-ying1HAN Dong-xing1LIU Bang-ling1YAO Lu1LIU Shao-yang2
(1.Department of Breast Surgery,Shanghai Construction Engineering Hospital,Shanghai 200080,China;2.Department of Orthopaedics,Shanghai Putuo District Central Hospital,Shanghai 200333,China)
关键词:
miR-145乳腺癌骨转移
Keywords:
miR-145Breast cancerBone metastasis
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2019.07.002
文献标志码:
A
摘要:
目的 探讨乳腺癌骨转移患者血清miR-145的表达水平及其临床意义。方法 采集上海市建工医院于2014年8月~2017年8月收治的160例乳腺癌患者的血清样本,其中乳腺癌骨转移患者与非骨转移患者各80例。采用实时荧光定量PCR检测血清样本中miR-145的表达水平,并分析其与有无骨转移,骨转移程度、骨痛程度的相关关系。结果 骨转移患者血清中miR-145的相对表达量低于乳腺癌非骨转移患者[(1.22±0.24)vs(2.57±0.38) ],差异有统计学意义(P<0.05);且miR-145的相对表达量与患者的骨转移程度(r=-0.873)、骨痛程度(r=-0.685)呈负相关,差异有统计学意义(P<0.05)。结论 乳腺癌骨转移患者血清miR-145的表达量明显降低,且与病情呈负相关,miR-145可作为诊断及病情评估指标。
Abstract:
Objective To investigate the expression level of serum miR-145 in patients with breast cancer and its clinical significance. Methods Serum samples of 160 breast cancer patients admitted to Shanghai Construction Engineering Hospital from August 2014 to August 2017 were collected, including 80 patients with breast cancer metastasis and non-bone metastasis. Real-time quantitative PCR was used to detect the expression level of miR-145 in serum samples, and its correlation with bone metastasis, bone metastasis and bone pain was analyzed. Results The relative expression of miR-145 in patients with bone metastases was lower than that in patients with non-bone metastases [(1.22±0.24) vs (2.57±0.38)], the difference was statistically significant (P<0.05); and miR-145 The relative expression was negatively correlated with the degree of bone metastasis (r=-0.873) and the degree of bone pain (r=-0.685), the difference was statistically significant (P<0.05). Conclusion The expression of serum miR-145 is significantly decreased in patients with bone metastasis from breast cancer, and it is negatively correlated with the condition. miR-145 can be used as a diagnostic and disease assessment index.

参考文献/References:


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更新日期/Last Update: 2019-04-01