[1]杨 震,宗文仓,赵艳辉.血脂异常与老年冠心病患者冠脉病变程度的相关性研究[J].医学信息,2019,(07):89-92.[doi:10.3969/j.issn.1006-1959.2019.07.026]
 YANG Zhen,ZONG Wen-cang,ZHAO Yan-hui.Correlation Study between Dyslipidemia and Degree of Coronary Artery Disease in Elderly Patients with Coronary Heart Disease[J].Medical Information,2019,(07):89-92.[doi:10.3969/j.issn.1006-1959.2019.07.026]
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血脂异常与老年冠心病患者冠脉病变程度的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年07期
页码:
89-92
栏目:
论著
出版日期:
2019-04-01

文章信息/Info

Title:
Correlation Study between Dyslipidemia and Degree of Coronary Artery Disease in Elderly Patients with Coronary Heart Disease
文章编号:
1006-1959(2019)07-0089-04
作者:
杨 震宗文仓赵艳辉
(天津市武清区人民医院心内科,天津 300000)
Author(s):
YANG ZhenZONG Wen-cangZHAO Yan-hui
(Department of Cardiology,People's Hospital of Wuqing District,Tianjin30O000,China)
关键词:
血脂冠状动脉粥样硬化性心脏病血脂比值相关性
Keywords:
Blood lipidCoronary atherosclerotic heart diseaseBlood lipid ratioCorrelation
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2019.07.026
文献标志码:
A
摘要:
目的 探讨血脂异常与老年冠心病患者冠脉病变程度的相关性。方法 选取2015年5月~2017年1月本院心内科住院的明确诊断为冠状动脉粥样硬化性心脏病(CHD)的150例老年患者设为CHD组。选取同期收治的150例非CHD患者为对照组。比较两组血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平,并计算N-HDL-C、LDL-C/N-HDL-C、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值。比较不同冠脉病变支数、不同病情严重程度的CHD患者的血脂及其比值。对血脂与冠脉病变支数、病情严重程度积分进行相关性分析。结果 CHD组患者LDL-C、TG、TC、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值均高于对照组,HDL-C水平低于对照组,差异均有统计学意义(P<0.05);不同冠脉病变支数各亚组间的TC、TG、N-HDL-C水平、TC/HDL-C比值差异存在统计学意义(P<0.05);TC、TG、N-HDL-C水平、TC/HDL-C比值均与冠脉病变支数均呈正相关(P<0.05);不同病情严重程度亚组间的LDL-C、TC、TG、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值差异存在统计学意义(P<0.05);CHD患者LDL-C、TC、TG、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值与冠状动脉病变积分均呈正相关(P<0.05)。结论 可以通过对血脂指标的监测,并计算N-HDL-C、TC/HDL-C、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值,来评估CHD病情的临床进展。
Abstract:
Objective To investigate the relationship between dyslipidemia and the severity of coronary artery disease in elderly patients with coronary heart disease.Methods A total of 150 elderly patients with coronary atherosclerotic heart disease (CHD) who were diagnosed with coronary heart disease (CHD) from May 2015 to January 2017 were enrolled in the CHD group. 150 non-CHD patients were enrolled in the same period. For the control group. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in serum were compared between the two groups, and N-HDL-C and LDL were calculated. -C/N-HDL-C, LDL-C/HDL-C, TC/HDL-C, TG/HDL-C values. Compare the blood lipids and their ratios of CHD patients with different coronary lesions and severity of different diseases. Correlation analysis was performed on the scores of blood lipids and coronary lesions and the severity of the disease.Results The levels of LDL-C, TG, TC, N-HDL-C, LDL-C/HDL-C, TC/HDL-C, TG/HDL-C in the CHD group were higher than those in the control group, and the HDL-C level was low. In the control group, the difference was statistically significant (P<0.05); there were statistically significant differences in TC, TG, N-HDL-C levels, and TC/HDL-C ratios among the subgroups of different coronary lesions (P<0.05); TC, TG, N-HDL-C level, TC/HDL-C ratio were positively correlated with coronary artery lesions (P<0.05); LDL-C between subgroups of different severity of disease TC, TG, N-HDL-C levels, LDL-C/HDL-C, TC/HDL-C, TG/HDL-C ratios were statistically significant (P<0.05); CHD patients with LDL-C, TC, TG, N-HDL-C level, LDL-C/HDL-C, TC/HDL-C, TG/HDL-C ratio were positively correlated with coronary artery lesion scores (P<0.05). Conclusion The clinical evaluation of CHD can be evaluated by monitoring the blood lipid index and calculating N-HDL-C, TC/HDL-C, LDL-C/HDL-C, TC/HDL-C, and TG/HDL-C values. progress.

参考文献/References:


[1]Schuurman AS,Vroegindewey MM,Kardys I,et al.Prognostic Value of Intravascular Ultrasound in Patients With Coronary Artery Disease[J].J Am Coll Cardiol,2018,72(17):2003-2011.
[2]AlBadri A,Sharif B,Wei J,et al.Intracoronary Bolus Injection Versus Intravenous Infusion of Adenosine for Assessment of Coronary Flow Velocity Reserve in Women With Signs and Symptoms of Myocardial Ischemia and No Obstructive Coronary Artery Disease[J].JACC Cardiovasc Interv,2018,11(20):2125-2127.
[3]孙佳艺,张倩,赵冬,等.北京市2007-2012年急性心肌梗死住院患者30天病死率变化趋势分析[J].中华流行病学杂志,2018,39(3):363-367.
[4]Lars Ryden,Grant PJ,Anker SD,et al.ESC guidelines on diabetes,pre-diabetes,and cardiovascular diseases developed in collaboration with the EASD-summary[J].Diab Vasc Dis Res,2014,11(3):133-173.
[5]Zhao D,Liu J,Xie W,et al.Cardiovascular risk assessment:a global perspective[J].Nat Rev Cardiol,2015,12(5):301-311.
[6]Li YH,Chao TH,Liu PY,et al.Lipid Lowering Therapy for Acute Coronary Syndrome and Coronary Artery Disease: Highlights of the 2017 Taiwan Lipid Guidelines for High Risk Patients[J].Acta Cardiol Sin,2018,34(5):371-378.
[7]Shabana NA,Ashiq S,Ijaz A,et al.Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects[J].Lipids Health Dis,2018,17(1):224.
[8]Zhao Q,Liu F,Wang YH,et al.LDL-C:HDL-C ratio and common carotid plaque in Xinjiang Uygur obese adults: a cross-sectional study[J].BMJ Open,2018,8(10):e022757.
[9]Li YH,Chao TH,Liu PY,et al.Lipid Lowering Therapy for Acute Coronary Syndrome and Coronary Artery Disease: Highlights of the 2017 Taiwan Lipid Guidelines for High Risk Patients[J].Acta Cardiol Sin,2018,34(5):371-378.
[10]Baez-Duarte BG,Zamora-Gínez I,González-Duarte R,et al.Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index as a reference criterion of risk for metabolic syndrome (MetS) and low insulin sensitivity in apparently healthy subjects[J].Gac Med Mex,2017,153(2):152-158.
[11]Kimak E,Zieba B,Duma D,et al.Myeloperoxidase level and inflammatory markers and lipid and lipoprotein parameters in stable coronary artery disease[J].Lipids Health Dis,2018,17(1):71.
[12]杨杰.血浆TC/HDL-C和LDL-C/HDL-C比值与冠心病严重程度的相关性分析[J].实用医药杂志,2017,34(1):14-16.
[13]黄卓山,钟钧琳,罗艳婷,等.冠心病患者LDL-C/HDL-C比值与冠脉病变严重程度的相关性[J].中山大学学报(医学科学版),2018,39(2):303-308.
[14]王铮华.血清HCY、LDL-C联合HDL-C检测在冠心病并发缺血性脑卒中患者病情评估中的应用价值[J].河南医学研究,2017,26(10):1772-1773.
[15]范艳平,卢经君,唐静怡,等.脂蛋白相关磷脂酶A2水平对老年稳定性冠心病患者心血管事件相关性的临床研究[J].中华老年心脑血管病杂志,2017,19(3):312-313.
[16]张添甜,张潇怡,孙光,等.老年原发性高血压患者心脏舒张功能的评价[J].中华老年心脑血管病杂志,2016,18(6):586-589.
[17]Baxa J,Ferda J.Coronary CT angiography-current options and future perspectives in the diagnosis of coronary artery disease[J].Cas LekCesk,2018,157(4):181-187.

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更新日期/Last Update: 2019-04-01