[1]孟君艳.加巴喷丁联合盐酸羟考酮对晚期癌因性疼痛患者的效果及对其疼痛介质的影响[J].医学信息,2019,32(10):146-147.[doi:10.3969/j.issn.1006-1959.2019.10.048]
　MENG Jun-yan.Effect of Gabapentin Combined with Oxycodone Hydrochloride on Patients with Advanced Cancer-induced Pain and its Effect on Pain Media[J].Journal of Medical Information,2019,32(10):146-147.[doi:10.3969/j.issn.1006-1959.2019.10.048]
点击复制

加巴喷丁联合盐酸羟考酮对晚期癌因性疼痛患者的效果及对其疼痛介质的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年10期
页码:
146-147
栏目:
药物与临床
出版日期:
2019-05-15

文章信息/Info

Title:
Effect of Gabapentin Combined with Oxycodone Hydrochloride on Patients with Advanced Cancer-induced Pain and its Effect on Pain Media
文章编号:
1006-1959（2019）10-0146-02
作者:
孟君艳
（天津西青医院药剂科，天津 300380）
Author(s):
MENG Jun-yan
(Department of Pharmacy,Tianjin Xiqing Hospital,Tianjin 300380,China)
关键词:
加巴喷丁; 盐酸羟考酮; 晚期癌因性疼痛; 疼痛介质
Keywords:
Gabapentin; Oxycodone hydrochloride; Advanced cancer causative pain; Pain mediator
分类号:
R730.5
DOI:
10.3969/j.issn.1006-1959.2019.10.048
文献标志码:
A
摘要:
目的 分析晚期癌因性疼痛患者治疗中加巴喷丁联合盐酸羟考酮的效果、对疼痛介质的影响。方法 选取76例晚期癌因性疼痛患者随机分成参照组37例和观察组39例。参照组给予盐酸羟考酮治疗，观察组给予加巴喷丁联合盐酸羟考酮治疗。比较用药前后两组疼痛评分及疼痛介质水平。结果 用药前两组疼痛数字量表（NRS）评分，5-羟色胺（5-HT）、多巴胺（DA）、去甲肾上腺素（NE）水平比较，差异无统计学意义（P＞0.05）；用药后观察组NRS评分、5-HT、DA、NE分别为（2.30±0.75）分、（682.05±85.93）ng/L、（13254.51±2546.01）ng/L、（468.63±52.74）ng/L，低于参照组的（4.21±0.63）分、（821.17±71.02）ng/L、（15862.01±2634.51）ng/L、（497.30±53.59）ng/L，且两组各项指标均较治疗前降低，差异均有统计学意义（P＜0.05）。结论 晚期癌因性疼痛患者治疗中加巴喷丁联合盐酸羟考酮可减轻疼痛、降低疼痛介质水平。
Abstract:
Objective To analyze the effect of gabapentin combined with oxycodone hydrochloride in the treatment of patients with advanced cancer-induced pain and its effect on pain media.Methods 76 patients with advanced cancer-induced pain were randomly divided into a reference group of 37 patients and an observation group of 39 patients.The reference group was given oxycodone hydrochloride treatment, and the observation group was given gabapentin combined with oxycodone hydrochloride. The pain scores and pain media levels were compared between the two groups before and after medication.Results There were no significant differences in the pain digital scale (NRS) scores, serotonin (5-HT), dopamine (DA) and norepinephrine (NE) levels between the two groups before treatment (P>0.05). The NRS scores, 5-HT, DA, and NE in the post-observation group were (2.30±0.75),(682.05±85.93) ng/L,(13254.51±2546.01) ng/L,(468.63±52.74) ng/L,respectively,which was lower than the reference group(4.21±0.63), (821.17±71.02) ng/L,(15862.01±2634.51) ng/L,(497.30±53.59) ng/L,and the indexes of the two groups were lower than before treatment,the differences were statistically significant (P<0.05).Conclusion Gabapentin combined with oxycodone hydrochloride in patients with advanced cancer-induced pain can reduce pain and reduce the level of pain media.

参考文献/References:

[1]蒋婷,吴畏,袁明勇,等.对一例晚期癌痛病人的药学服务[J].药学服务与研究,2017,17(6):423-426.
[2]杨建强,张菊英,罗浩杰,等.五指疼痛评估法在老年带状疱疹患者疼痛评估中的应用[J].中国麻风皮肤病杂志,2018,34(7):1482-1486.
[3]成东华.恶性肿瘤的TNM分期[J].中国实用外科杂志,2004, 24(5):317-319.
[4]陈卓园园,韩兴平,鞠梅.癌症患者癌痛自我效能感和生活质量现状调查[J].实用医学杂志,2017,33(4):636-638.
[5]李德辉,孙春霞,范焕芳.复方苦参注射液联合盐酸羟考酮缓释片治疗癌痛的系统评价[J].中国疼痛医学杂志,2017,23(5):98-99.
[6]高宏,殷东风,邢向荣,等.奥施康定联合加巴喷丁治疗癌性神经病理性疼痛的临床疗效及对免疫功能的影响[J].现代生物医学进展,2017,17(23):4479-4482.
[7]陈栋樑,李玉红,王志娟,等.羟考酮联合加巴喷丁用于重度癌痛患者的长期疗效及满意度[J].中国新药与临床杂志,2017, 36(4):47-52.
[8]上官文姬,李展春,程光齐,等.骨碎补总黄酮对绝经后骨质疏松大鼠疼痛介质和疼痛反应影响[J].辽宁中医药大学学报,2017,19(3):12-14.

相似文献/References:

[1]高 营,孙 伟.加巴喷丁治疗酒依赖的临床疗效[J].医学信息,2019,32(17):142.[doi:10.3969/j.issn.1006-1959.2019.17.047]
　GAO Ying,SUN Wei.Clinical Efficacy of Gabapentin in the Treatment of Alcohol Dependence[J].Journal of Medical Information,2019,32(10):142.[doi:10.3969/j.issn.1006-1959.2019.17.047]
[2]韩丽丽.盐酸羟考酮注射液用于全麻患者术后镇痛的 有效性和安全性研究[J].医学信息,2019,32(13):145.[doi:10.3969/j.issn.1006-1959.2019.13.045]
　HAN Li-li.Efficacy and Safety of Oxycodone Hydrochloride Injection for Postoperative Analgesia in Patients with General Anesthesia[J].Journal of Medical Information,2019,32(10):145.[doi:10.3969/j.issn.1006-1959.2019.13.045]
[3]刘明明,黄仕豪.盐酸羟考酮缓释片和硫酸吗啡缓释片对结直肠癌重度疼痛患者的效果及对炎症因子水平和免疫指标的影响[J].医学信息,2022,35(21):134.[doi:10.3969/j.issn.1006-1959.2022.21.035]
　LIU Ming-ming,HUANG Shi-hao.Effect of Oxycodone Hydrochloride Prolonged-release Tablets and Morphine Sulfate Prolonged-release Tablets on Patients with Severe Pain of Colorectal Cancer,Levels of Inflammatory Factors and Immune Indexes[J].Journal of Medical Information,2022,35(10):134.[doi:10.3969/j.issn.1006-1959.2022.21.035]

更新日期/Last Update: 2019-05-15