[1]张雪利.血清1,25(OH)2D3、MGO与2型糖尿病痛性神经病变的相关性研究[J].医学信息,2019,32(19):47-50.[doi:10.3969/j.issn.1006-1959.2019.19.015]
　ZHANG Xue-li.Correlation Between Serum 1,25(OH)2D3,MGO and Painful Neuropathy in Type 2 Diabetes[J].Journal of Medical Information,2019,32(19):47-50.[doi:10.3969/j.issn.1006-1959.2019.19.015]
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血清1,25(OH)2D3、MGO与2型糖尿病痛性神经病变的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年19期
页码:
47-50
栏目:
综述
出版日期:
2019-10-01

文章信息/Info

Title:
Correlation Between Serum 1,25(OH)2D3,MGO and Painful Neuropathy in Type 2 Diabetes
文章编号:
1006-1959（2019）19-0047-04
作者:
张雪利
（赣州市人民医院老年病科，江西 赣州 341000）
Author(s):
ZHANG Xue-li
(Department of Geriatrics,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China)
关键词:
糖尿病痛性神经病变; 甲基乙二醛; 1; 25-二羟维生素D3
Keywords:
Diabetic painful neuropathy; Methylglyoxal; 1; 25-dihydroxyvitamin D3
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2019.19.015
文献标志码:
A
摘要:
年来，糖尿病痛性神经病变（PDN）成为内分泌领域难以攻克的问题，中枢敏化及炎症反应是其发病的重要机制。甲基乙二醛（MGO）作为晚期糖基化终末产物（AGEs）的一种前体，能快速生成AGEs，可以通过蛋白转录后修饰致中枢敏化，提示MGO可能参与了PDN的发生发展。维生素D具有抗炎和免疫调节功能，1,25(OH)2D3是其活性形式，已有研究表明VitD3可以抑制2型糖尿病患者炎症细胞因子的表达，对预防2型糖尿病的发生发展和糖尿病并发症的改善具有很好的作用，但具体机制不明确。MGO与1,25(OH)2D3是否可能介导了糖尿病痛性神经病变的机制，两者之间是否存在一定的相关性，国内外尚鲜有相关报道。因此，本研究就MGO及1,25(OH)2D3与糖尿病痛性神经病变的相关性及两者之间关系进行综述。
Abstract:
In recent years, diabetic painful neuropathy (PDN) has become a difficult problem for scholars in the field of endocrinology. Central sensitization and inflammatory response are important mechanisms for its pathogenesis. Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), can rapidly generate AGEs, which can be centrally sensitized by post-transcriptional modification of proteins, suggesting that MGO may be involved in the development of PDN.Vitamin D has anti-inflammatory and immunoregulatory functions,1,25(OH)2D3 is its active form. It has been shown that VitD3 can inhibit the expression of inflammatory cytokines in patients with type 2 diabetes, suggesting a good effect on preventing the development of type 2 diabetes and improving the complications of diabetes. But the specific mechanism is not clear. Whether MGO and 1,25(OH)2D3 may mediate the mechanism of diabetic painful neuropathy, there is a certain correlation between them, and there are few reports at home and abroad. Therefore, this study reviewed the relationship between MGO and 1,25(OH)2D3 and diabetic painful neuropathy and the relationship between the two.

参考文献/References:

[1]Albers JW,Popbusui R.Diabetic neuropathy:mechanisms,emerging,Treatments,and subtypes[J].Curr Neurol Neurosci Rep,2014,14(18):473. [2]Wang FP,Zhang PA,Yang XY.Updates on the Pathways of Toll-Like Receptors Mediated by HMGB1[J].J Mod Lab Med,2017,5,32(3):162-164. [3]Ma YQ,Chen YR,Leng YF,et al.Tanshinone ⅡA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain[J].Evidence-Based Complementary and Alternative Medicine,2014(2014):639563. [4]Nishida T,Tsubota M,Kawaishi Y,et al.Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats[J].Toxicology,2016(365):48-58. [5]Nam H,Kim HY,Choi JS,et al.Association between Serum 25-hydroxyvitamin D Levels and Type 2 Diabetes in Korean Adults[J].Chonnam Medical Journal,2017,53(1):73-77. [6]Usluogullari CA,Balkan F,Caner S,et al.The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus[J].BMC Endocrine Disorders,2015(15):33. [7]Wieder-Huszla S,Jurczak A,Szkup M,et al.Relationships between Vitamin D3 and Metabolic Syndrome[J].Int J Environ Res Public Health,2019,16(2):175. [8]文芳梅,严建宇.老年2型糖尿病患者血清25.羟维生素D3水平与胰岛素抵抗的相关性[J].中国医药导报,2016,13(24):77-80. [9]张艳玲,张栩,张雯雯,等.济南地区成人血清25(OH)D水平与空腹血糖的相关性[J].山东大学学报(医学版),2014,52(3):59-63. [10]Seham E,Abdelsadek,Entesar O,et al.Serum 25(OH)vitamin D level and itsrelation to diabetic peripheral neuropathyin Egyptian patients with type 2 diabetesmellitus[J].The Egyptian Journal of Neurology,Psychiatry and Neurosurgery,2018(54):36. [11]Hosseini A,Abdollahi M.Diabetic neuropathy and oxidative stress:therapeutic perspectives[J].Oxidative Medicine and Cellular Longevity,2013(2013):168039. [12]潘佳秋,徐微微,张超.新诊断2型糖尿病患者血清高迁移率族蛋白1和Toll样受体4水平变化及其与胰岛素抵抗的关系研究[J].中国全科医学,2013,16(3):252-254. [13]陆海英,曲鹏,丁彦春等.2型糖尿病患者单核细胞TLR4表达及其与血浆TNF-α相关性研究[J].中国全科医学,2013, 16(3):252-254. [14]Alam U,Arul-Devah V,Javed S,et al.Vitamin D and Diabetic Complications:True or FalseProphet[J].Diabetes Ther,2016,7(1):11-26. [15]He R,Hu Y,Zeng H,et al.Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with type 2 diabetes[J].Diabetes Metab Res Rev,2017,33(2):e2820. [16]Shillo P,Selvarajah D,Greig M,et al.Reduced vitamin D levels in painful diabetic peripheral neuropathy[J].Diabetic Medicine,2018,36(Suppl2):13789. [17]李玉艳.维生素 D与2型糖尿病的相关性研究[J].医学信息,2016,29(32):277-278. [18]赵新翠,陈婕.2型糖尿病患者周围神经病变患者转化生长因子13,与血清25-OH维生素D表达水平及相关性研究[J].检验医学与临床,2017,14(12):1802-1804. [19]白秋芳,陈乐菊.糖尿病并发周围神经病变与血清25-羟维生素D3表达水平的相关性研究[J].现代医药卫生,2017,33(15):2257-2258. [20]武红梅,黄莹,胡园园,等.血清MMP-9,25羟维生素D3表达与2型糖尿病周围神经病变相关性[J].辽宁医学院学报,2017,38(2):4-6. [21]赵春楠,彭群新,李艳萌,等.基质金属蛋白酶组织抑制因子-1在2型糖尿病患者中的表达变化[J].广东医学,2014,35(6):888-890. [22]Shehab D,Al-Jarallah K,Mojiminiyi OA,et al.Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes[J].Diabet Med,2012,29(1):43-49. [23]Alamdari A,Mozafari R,Tafakhori A,et al.An inverse association between serum vitamin D levels with the presence and severity of impaired nerve conduction velocity and large fiber peripheral neuropathy in diabetic subjects[J].Neurol Sci,2015,36(7):1121-1126. [24]Maser RE,Lenhard MJ,Pohlig RT.Vitamin D insufficiency is associated with reduced parasympathetic nerve fiber function in type 2 diabetes[J].Endocr Pract,2015,21(2):174-181. [25]Lv WS,Zhao WJ,Gong SL,et al.Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes:a systematic review and meta-analysis[J].J Endocrinol Invest,2015,38(5):513-518. [26]Celikbilek A,Gocmen AY,Tanik N,et al.Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey[J].Acta Neurol Belg,2015,115(1):47-52. [27]Herrmann M,Sullivan DR,Veillard AS,et al.Serum 25-hydroxyvitamin D:a predictor of macrovascular and microvascular complications in patients with type 2 diabetes[J].Diabetes Care,2015,38(3):521-528. [28]Qu GB,Wang LL,Tang X,et al.The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus:An update systematic review and meta-analysis[J].Journal of Clinical&Translational Endocrinology,2017,9(25):25-31. [29]Cameron NE,Cotter MA.Effects of protein kinase cp inhibition on neurovascular dysfunction in diabetic rats:interackion with oxidative stress and essential fatty acid dysmetabolism[J].Diabetes Metah Res Rev,2002,18(4):315-323. [30]Singh R,Barden A,Mo T,et al.Advanced glycation end-products:a review[J].Diabetologia,2001,44(2):129-146. [31]Karachalias N,Babae-Jadidi R,Ahmed N,et al.Accumulation of fructosyl-lysine and advanced glycation end products in the kidney,retina and peripheral nerve of streptozotocin-induced diabetic rats[J].Biochemical Society Transactions,2003,31(6):1423-1425. [32]Tongdao X,Qun D,Zhi W.Therapeutic effect of calcitriol on painful peripheral neuropathy in diabetic patients[J].Cli Res,2016,24(12):60-61. [33]Bener A,Al-Hamaq AO,Kurtulus EM,et al.The role of vitamin D, obesity and physical exercise in regulation of glycemia in Type 2 Diabetes Mellitus patients[J].Diabetes&metabolic syndrome,2016,10(4):198-204. [34]秦宏超,张真稳.2型糖尿病周围神经病变患者外周血CD4+调节性T细胞与25-(OH)D3的关系及其意义[J].中国现代医学杂志,2018,28(18):45-49. [35]Fan L,Zhang Y,Zhu J,et al.Association of vitamin D deficiency with diabetic peripheral neuropathy and diabetic nephropathy in Tianjin, China[J].Asia Pac J Clin Nutr,2018,27(3):599-606. [36]Qu GB,Wang LL,Tang X,et al.The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: An update systematic review and meta-analysis[J].J Clin Transl Endocrinol,2017,9(9):25-31. [37]Bilir B,Tulubas F,Bilir BE,et al.The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy[J].Journal of Physical Therapy Science,2016,28(7):2159-2163. [38]Hehab D,Al-Jarallah K,Mojiminiyi OA,et al.Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?[J].Diabetic Medicine,2014,29(1):43-49. [39]Lv WS,Zhao WJ,Gong SL,et al.Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes[J].J Endocrinol Invest,2015,38(5):513-518. [40]尹秀梅,游娜,缪珩,等.补充维生素D对肥胖或糖代谢异常患者胰岛素抵抗及血糖改善效果的Meta分析[J].中华内分泌代谢杂志,2016,32(8):663-667. [41]Yan ZT,Liu YS.Relationship between blood lipids,blood glucose,inflammatory factors and type 2 diabetes mellitus and its complications[J].Int J Lab Med,2018,39(18):2296-2299.

更新日期/Last Update: 2019-10-01