[1]张雪利.血清1,25(OH)2D3、MGO与2型糖尿病痛性神经病变的相关性研究[J].医学信息,2019,(19):47-50.[doi:10.3969/j.issn.1006-1959.2019.19.015]
 ZHANG Xue-li.Correlation Between Serum 1,25(OH)2D3,MGO and Painful Neuropathy in Type 2 Diabetes[J].Medical Information,2019,(19):47-50.[doi:10.3969/j.issn.1006-1959.2019.19.015]
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血清1,25(OH)2D3、MGO与2型糖尿病痛性神经病变的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年19期
页码:
47-50
栏目:
综述
出版日期:
2019-10-01

文章信息/Info

Title:
Correlation Between Serum 1,25(OH)2D3,MGO and Painful Neuropathy in Type 2 Diabetes
文章编号:
1006-1959(2019)19-0047-04
作者:
张雪利
(赣州市人民医院老年病科,江西 赣州 341000)
Author(s):
ZHANG Xue-li
(Department of Geriatrics,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China)
关键词:
糖尿病痛性神经病变甲基乙二醛125-二羟维生素D3
Keywords:
Diabetic painful neuropathyMethylglyoxal125-dihydroxyvitamin D3
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2019.19.015
文献标志码:
A
摘要:
年来,糖尿病痛性神经病变(PDN)成为内分泌领域难以攻克的问题,中枢敏化及炎症反应是其发病的重要机制。甲基乙二醛(MGO)作为晚期糖基化终末产物(AGEs)的一种前体,能快速生成AGEs,可以通过蛋白转录后修饰致中枢敏化,提示MGO可能参与了PDN的发生发展。维生素D具有抗炎和免疫调节功能,1,25(OH)2D3是其活性形式,已有研究表明VitD3可以抑制2型糖尿病患者炎症细胞因子的表达,对预防2型糖尿病的发生发展和糖尿病并发症的改善具有很好的作用,但具体机制不明确。MGO与1,25(OH)2D3是否可能介导了糖尿病痛性神经病变的机制,两者之间是否存在一定的相关性,国内外尚鲜有相关报道。因此,本研究就MGO及1,25(OH)2D3与糖尿病痛性神经病变的相关性及两者之间关系进行综述。
Abstract:
In recent years, diabetic painful neuropathy (PDN) has become a difficult problem for scholars in the field of endocrinology. Central sensitization and inflammatory response are important mechanisms for its pathogenesis. Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), can rapidly generate AGEs, which can be centrally sensitized by post-transcriptional modification of proteins, suggesting that MGO may be involved in the development of PDN.Vitamin D has anti-inflammatory and immunoregulatory functions,1,25(OH)2D3 is its active form. It has been shown that VitD3 can inhibit the expression of inflammatory cytokines in patients with type 2 diabetes, suggesting a good effect on preventing the development of type 2 diabetes and improving the complications of diabetes. But the specific mechanism is not clear. Whether MGO and 1,25(OH)2D3 may mediate the mechanism of diabetic painful neuropathy, there is a certain correlation between them, and there are few reports at home and abroad. Therefore, this study reviewed the relationship between MGO and 1,25(OH)2D3 and diabetic painful neuropathy and the relationship between the two.

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更新日期/Last Update: 2019-10-01