[1]冯晓阳,陆海涛,王 薇,等.溶菌酶肠溶片治疗过敏性紫癜的临床疗效[J].医学信息,2019,32(19):153-154157.[doi:10.3969/j.issn.1006-1959.2019.19.050]
　FENG Xiao-yang,LU Hai-tao,WANG Wei,et al.Clinical Efficacy of Lysozyme Enteric-coated Tablets in the Treatment of Henoch-Schonlein Purpura[J].Journal of Medical Information,2019,32(19):153-154157.[doi:10.3969/j.issn.1006-1959.2019.19.050]
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溶菌酶肠溶片治疗过敏性紫癜的临床疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年19期
页码:
153-154157
栏目:
药物与临床
出版日期:
2019-10-01

文章信息/Info

Title:
Clinical Efficacy of Lysozyme Enteric-coated Tablets in the Treatment of Henoch-Schonlein Purpura
文章编号:
1006-1959（2019）19-0153-03
作者:
冯晓阳; 陆海涛; 王 薇; 刘利君; 牛艳东; 段昕所
（河北承德医学院附属医院皮肤科，河北 承德 067000）
Author(s):
FENG Xiao-yang; LU Hai-tao; WANG Wei; LIU Li-jun; NIU Yan-dong; DUAN Xin-suo
(Department of Dermatology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)
关键词:
溶菌酶; 过敏性紫癜; 症状缓解时间
Keywords:
Lysozyme; Henoch-Schonlein purpura; Symptom relief time
分类号:
R758.2
DOI:
10.3969/j.issn.1006-1959.2019.19.050
文献标志码:
A
摘要:
目的 探讨溶菌酶肠溶片治疗过敏性紫癜的临床疗效。方法 选择2017年1月~2018年6月我院收治的过敏性紫癜患者108例，采用随机数字表法分为实验组和对照组，每组54例。对照组给予常规治疗，包括口服维生素C片和芦丁片，实验组在对照组基础上给予溶菌酶肠溶片口服治疗，比较两组临床疗效、症状缓解时间及复发情况。结果 实验组总有效率为83.33%，高于对照组的66.67%，差异有统计学意义（P＜0.05）。实验组皮肤紫癜消退时间及尿常规恢复正常时间短于对照组，差异有统计学意义（P＜0.05）。实验组复发率为29.63%，低于对照组的50.00%，差异有统计学意义（P＜0.05）。结论 溶菌酶肠溶片治疗过敏性紫癜疗效显著，可有效缓解临床症状，且复发率小。
Abstract:
Objective To investigate the clinical efficacy of lysozyme enteric-coated tablets in the treatment of Henoch-Schonlein purpura.Methods A total of 108 patients with Henoch-Schonlein purpura admitted to our hospital from January 2017 to June 2018 were enrolled. The patients were divided into experimental group and control group by random number table, with 54 cases in each group. The control group received routine treatment, including oral vitamin C tablets and rutin tablets， the experimental group received oral administration of lysozyme enteric-coated tablets on the basis of the control group. The clinical efficacy, time to symptom relief and recurrence were compared between the two groups.Results The total effective rate of the experimental group was 83.33%, which was higher than that of the control group 66.67%,the difference was statistically significant (P<0.05). The time of skin purpura regression and the normal time of urine routine recovery in the experimental group were shorter than those in the control group,the difference was statistically significant (P<0.05). The recurrence rate of the experimental group was 29.63%, which was lower than that of the control group 50.00%,the difference was statistically significant (P<0.05).Conclusion The lysozyme enteric-coated tablets are effective in the treatment of Henoch-Schonlein purpura, which can effectively alleviate clinical symptoms and have a small recurrence rate.

参考文献/References:

[1]赵辨.中国临床皮肤病学[M].南京:江苏凤凰科学技术出版社,2017:947-949. [2]Pannuru P,Rani A,Venkatesu P,et al.The effects of biological buffers TRIS,TAPS,TES on the stability of lysozyme[J].Int J Biol Macromol,2018(112):720-727. [3]庞恋苏,李亚男.重组人溶菌酶的研究进展[J].中华老年口腔医学杂志,2017,15(5):306-309. [4]刘伟.雷公藤多苷联合甘利欣治疗过敏性紫癜疗效观察[J].中国麻风皮肤病杂志,2015,31(5):317-320. [5]王业涛.复方甘草酸苷联合西咪替丁治疗小儿过敏性紫癜的疗效观察[J].临床医药文献杂志,2018,5(63):168. [6]谢爱娣,陈晓梨,刘锦群.成人过敏性紫癜28例临床分析[J].皮肤性病诊疗学杂志,2015,22(3):196-198. [7]丁一,张艺杰,苗青.儿童过敏性紫癜256例临床分析[J].中国麻风皮肤病杂志,2016,32(6):348-350. [8]蔡丽丽,郝维民,夏宏林.淋巴细胞亚群检测在小儿过敏性紫癜诊治中的应用[J].安徽医药,2018,22(8):1507-1510. [9]徐小红,田小华,潘凤娟,等.链球菌感染与过敏性紫癜发病的关系[J].辽宁医学杂志,2016,30(3):13-14. [10]王辉,陆瑶伽.单磷酸阿糖腺苷注射剂联合溶菌酶肠溶片治疗小儿疱疹性口腔炎的临床研究[J].中国临床药理学杂志,2017,33(14):1311-1313. [11]Oliver WT,Wells JE.Lysozyme as an alternative togrowth promoting antibiotics in swine production[J].Journal of Animal Scienceand Biotechnology,2015,6(1):35. [12]朱元镇,刘婧仪,于常红.溶菌酶的研究进展及应用[J].山东医学高等专科学校学报,2018,40(3):207-210.

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更新日期/Last Update: 2019-10-01