[1]郭利平,牛瑞兵,东晓仙,等.卡介菌多糖核酸对寻常型白癜风患者外周血Treg细胞的影响[J].医学信息,2019,32(20):82-84.[doi:10.3969/j.issn.1006-1959.2019.20.022]
　GUO Li-ping,NIU Rui-bing,DONG Xiao-xian,et al.Effect of BCG-polysaccharide Nucleic Acid on Peripheral Blood Treg Cells in Patients with Vitiligo Vulgaris[J].Journal of Medical Information,2019,32(20):82-84.[doi:10.3969/j.issn.1006-1959.2019.20.022]
点击复制

卡介菌多糖核酸对寻常型白癜风患者外周血Treg细胞的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年20期
页码:
82-84
栏目:
论著
出版日期:
2019-10-15

文章信息/Info

Title:
Effect of BCG-polysaccharide Nucleic Acid on Peripheral Blood Treg Cells in Patients with Vitiligo Vulgaris
文章编号:
1006-1959（2019）20-0082-03
作者:
郭利平1; 牛瑞兵2; 东晓仙1; 郭 隽1
（鄂尔多斯市中心医院皮肤科1，检验科2，内蒙古 鄂尔多斯 017000）
Author(s):
GUO Li-ping; NIU Rui-bing; DONG Xiao-xian; GUO Jun
(Department of Dermatology1,Department of Clinical Laboratory2,Erdos City Center Hospital,Erdos 017000,Inner Mongolia,China)
关键词:
寻常型白癜风; 卡介菌多糖核酸; Treg细胞
Keywords:
Vitiligo vulgaris; BCG polysaccharide nucleic acid; Treg cells
分类号:
R758.41
DOI:
10.3969/j.issn.1006-1959.2019.20.022
文献标志码:
A
摘要:
目的 探讨卡介菌多糖核酸BCG-PSN联合308 nm准分子光对寻常型白癜风患者外周血Treg细胞的影响。方法 选取2013年9月~2017年5月我院收治的寻常型白癜风患者120例设为治疗组，采用随机数字表法分成Ⅰ组和Ⅱ组，各60例。Ⅰ组采用308 nm准分子光单独治疗，Ⅱ组联合卡介菌多糖核酸肌注。另选取同期我院健康体检者30例作为对照组，比较治疗组与对照组外周血Treg细胞比值、治疗组不同分期外周血Treg细胞比值、各组治疗前后外周血Treg细胞比值以及Ⅰ组和Ⅱ组治疗总有效率。结果 治疗组外周血Treg细胞比值低于对照组，差异有统计学意义（P＜0.05）；进展期外周血Treg细胞比值低于稳定期，差异有统计学意义（P＜0.05）；与对照组比较，Treg细胞比值均降低，且进展期下降更明显；治疗后Ⅰ组、Ⅱ组Treg细胞比值均较治疗前升高，且Ⅱ组升高更为明显，差异有统计学意义（P＜0.05）；治疗后Ⅰ组Treg细胞比值低于对照组，差异有统计学意义（P＜0.05）；Ⅱ组治疗总有效率高于Ⅰ组，差异有统计学意义（P＜0.05）。结论 BCG-PSN可以通过增加Treg细胞水平提高患者细胞免疫功能，临床疗效确切，安全性高，不良反应少，值得临床应用。
Abstract:
Objective To investigate the effect of BCG-PSN combined with 308 nm excimer light on peripheral blood Treg cells in patients with vitiligo vulgaris.Methods 120 patients with vitiligo vulgaris admitted to our hospital from September 2013 to May 2017 were enrolled in the treatment group. They were divided into group I and group II by random number table, 60 cases each. Group I was treated with 308 nm excimer light alone, and group II was combined with BCG polysaccharide nucleic acid. In addition, 30 healthy subjects in our hospital were selected as the control group. The ratio of peripheral blood Treg cells in the treatment group and the control group, the ratio of Treg cells in the peripheral blood of the different treatment groups, the ratio of Treg cells in the peripheral blood of each group before and after treatment, and the groups I and II. The total effective rate of treatment in the group.Results The ratio of Treg cells in the peripheral blood of the treatment group was lower than that of the control group , the difference was statistically significant(P<0.05). The ratio of Treg cells in the peripheral blood was lower than that in the stable phase, the difference was statistically significant(P<0.05). Compared with the control group, the ratio of Treg cells decreased, and the progression decreased. Obviously, the ratio of Treg cells in group I and group II increased after treatment, and the increase in group II was more significant , the difference was statistically significant(P<0.05). The ratio of Treg cells in group I after treatment was compared with the control group, the difference was statistically significant(P<0.05). The total effective rate of group II was higher than that of group I , the difference was statistically significant(P<0.05).Conclusion BCG-PSN can improve the cellular immune function of patients by increasing the level of Treg cells. The clinical efficacy is clear, the safety is high, and the adverse reactions are few, which is worthy of clinical application.

参考文献/References:

[1]Zhou L,Li K,Shi YL,et al.Systemic analyses of immunophenotypes of peripheral T cells non-segmental vitiligo:implication of defective natural killer T cells[J].Pigment Cell Melanoma Res,2012,25(5):602-611. [2]Tembhre MK,Parihar AS,Sharma VK,et al.Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation[J].Br J Dermatol,2015,172(4):940-950. [3]王迪,苗青,王萍.白癜风患者血清中IL-33和TNF-α水平的研究[J].中国美容医学,2019,28(2):91-93. [4]李建英,刘津民,曹海育,等.卡介菌多糖核酸对白癜风的免疫调节作用[J].中华临床医师杂志,2015,9(12):2426-2428. [5]赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2013:1268-1273. [6]卢保振,柏冰雪.调节性T细胞在白癜风发病中的研究进展[J].国际免疫学杂志,2016,39(1):93-96. [7]赵娟娟.ATO对SAA患者外周血中CD4+CD25+CD127low调节性T细胞比例的调节作用[D]. 郑州大学, 2018. [8]Basak PY,Adiloglu AK,Ceyhan AM,et a1.The role of helper and regulatory.T cells in the pathogenesis of vitiligo[J].J Am Acad Derntatol,2009,60(2):256-260. [9]顾明生,刘海琴,赵婧.窄谱中波紫外线联合退白颗粒治疗白癜风疗效与患者CD4+CD25+Treg水平分析[J].皮肤病与性病,2017,39(2):79-82. [10]Lili Y,Yi W,Ji Y,et al.Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo[J].PLoS One,2012,7(5):e37513. [11]李泓馨,王华,高天文.寻常型进展期白癜风患者外周血CD4+CD25+调节性T细胞检测[J].临床皮肤科杂志,2008,37(11):714-716. [12]王洋.卡介菌多糖核酸联合奥洛他定治疗慢性荨麻疹的临床疗效观察[D].大连医科大学,2018.

更新日期/Last Update: 2019-10-15