[1]周忠梅.前列地尔辅助常规治疗冠心病不稳定型心绞痛的效果及对患者凝血功能的影响[J].医学信息,2019,(20):147-149.[doi:10.3969/j.issn.1006-1959.2019.20.046]
 ZHOU Zhong-mei.Effect of Alprostadil on Routine Treatment of Unstable Angina Pectoris in Coronary Heart Disease and its Effect on Coagulation Function in Patients[J].Medical Information,2019,(20):147-149.[doi:10.3969/j.issn.1006-1959.2019.20.046]
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前列地尔辅助常规治疗冠心病不稳定型心绞痛的效果及对患者凝血功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年20期
页码:
147-149
栏目:
药物与临床
出版日期:
2019-10-15

文章信息/Info

Title:
Effect of Alprostadil on Routine Treatment of Unstable Angina Pectoris in Coronary Heart Disease and its Effect on Coagulation Function in Patients
文章编号:
1006-1959(2019)20-0147-03
作者:
周忠梅
(沈阳市苏家屯区中西医结合医院内科病房,辽宁 沈阳 110000)
Author(s):
ZHOU Zhong-mei
(Internal Ward, Sujiatun District Hospital of Integrated Traditional Chinese and Western Medicine,Shenyang 110000,Liaoning,China)
关键词:
冠心病不稳定型心绞痛前列地尔内皮素同型半胱氨酸
Keywords:
Coronary heart diseaseUnstable angina pectorisAlprostadilEndothelinHomocysteine
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2019.20.046
文献标志码:
A
摘要:
目的 观察前列地尔辅助常规治疗冠心病不稳定型心绞痛 (UAP) 患者的临床效果及其对患者血管内皮损伤和凝血功能的影响。方法 选择我院2018年1月~4月收治的62例UAP患者,按照随机数字法分为研究组各对照组,各31例。对照组予以常规治疗,研究组在对照组的基础上联合前列地尔治疗。比较两组患者血浆ET、Hcy、纤维蛋白原(FIB)、D-二聚体、血清基质金属蛋白酶(MMP-2)、肿瘤坏死因子(TNF-ɑ)、白细胞介素(IL-6、IL-8)及高敏C反应蛋白(hs-CRP)水平。结果 治疗后,研究组血浆ET、Hcy以及血清MMP-9水平分别为(80.41±8.49)pg/ml、(13.91±1.58)μmol/L、(183.61±18.58)ng/ml,均低于对照组的(96.68±9.74)pg/ml、(16.26±1.74)μmol/L、(224.13±21.94)ng/ml,差异有统计学意义(P<0.05);研究组FIB和D-二聚体水平分别为(2.91±0.23)g/L、(0.36±0.08)mg/L,均低于对照组的(3.67±0.32)g/L、(0.63±0.09)mg/L,差异有统计学意义(P<0.05);研究组血清hs-CRP、TNF-ɑ、IL-6、IL-8水平分别为(2.58±0.31)mg/L、(2.46±0.17)μg/L、(76.21±7.49)ng/L、(16.21±1.69)ng/L,均低于对照组的(3.72±0.25)mg/L、(3.15±0.18)μg/L、(87.31±8.49)ng/L、(18.51±1.23)ng/L,差异有统计学意义(P<0.05)。结论 UAP患者采用前列地尔辅助常规治疗可有效降低血管内皮损伤,缓解炎症反应,降低血液黏度,改善患者预后。
Abstract:
Objective To investigate the effect of alprostadil in the treatment of patients with unstable angina pectoris (UAP) and its effects on vascular endothelial injury and coagulation function. Methods 62 patients with UAP admitted to our hospital from January to April 2018 were enrolled.According to the random number method, the study group and the control group were divided into 31 cases. The control group received routine treatment, and the study group was treated with alprostadil on the basis of the control group. Plasma ET, Hcy, fibrinogen (FIB), D-dimer, serum matrix metalloproteinase (MMP-2), tumor necrosis factor (TNF-ɑ),Interleukin (IL-6,IL-8) and high-sensitivity C-reactive protein (hs-CRP) levels. Results After treatment, plasma ET, Hcy and serum MMP-9 levels in the study group were (80.41±8.49) pg/ml, (13.91±1.58) μmol/L, and (183.61±18.58) ng/ml, respectively, which were lower than the control group(96.68±9.74) pg/ml, (16.26±1.74) μmol/L, (224.13±21.94) ng/ml, the difference was statistically significant (P<0.05); the study group FIB and D-dimer levels were respectively (2.91±0.23) g/L, (0.36±0.08) mg/L, which were lower than (3.67±0.32) g/L and (0.63±0.09) mg/L in the control group, the difference was statistically significant (P<0.05); serum hs-CRP, TNF-ɑ, IL-6, IL-8 levels in the study group were (2.58±0.31) mg/L, (2.46±0.17) μg/L, (76.21±7.49) ng/L, (16.21±1.69) ng/L, were lower than the control group (3.72±0.25) mg/L, (3.15±0.18) μg/L,(87.31±8.49) ng/L,(18.51±1.23) ng/L, the difference was statistically significant (P<0.05). Conclusion The use of alprostadil in the UAP patients can effectively reduce vascular endothelial injury, relieve inflammation, reduce blood viscosity and improve patient prognosis.

参考文献/References:

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更新日期/Last Update: 2019-10-15