[1]周忠梅.前列地尔辅助常规治疗冠心病不稳定型心绞痛的效果及对患者凝血功能的影响[J].医学信息,2019,32(20):147-149.[doi:10.3969/j.issn.1006-1959.2019.20.046]
　ZHOU Zhong-mei.Effect of Alprostadil on Routine Treatment of Unstable Angina Pectoris in Coronary Heart Disease and its Effect on Coagulation Function in Patients[J].Journal of Medical Information,2019,32(20):147-149.[doi:10.3969/j.issn.1006-1959.2019.20.046]
点击复制

前列地尔辅助常规治疗冠心病不稳定型心绞痛的效果及对患者凝血功能的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年20期
页码:
147-149
栏目:
药物与临床
出版日期:
2019-10-15

文章信息/Info

Title:
Effect of Alprostadil on Routine Treatment of Unstable Angina Pectoris in Coronary Heart Disease and its Effect on Coagulation Function in Patients
文章编号:
1006-1959（2019）20-0147-03
作者:
周忠梅
（沈阳市苏家屯区中西医结合医院内科病房，辽宁 沈阳 110000）
Author(s):
ZHOU Zhong-mei
(Internal Ward, Sujiatun District Hospital of Integrated Traditional Chinese and Western Medicine,Shenyang 110000,Liaoning,China)
关键词:
冠心病; 不稳定型心绞痛; 前列地尔; 内皮素; 同型半胱氨酸
Keywords:
Coronary heart disease; Unstable angina pectoris; Alprostadil; Endothelin; Homocysteine
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2019.20.046
文献标志码:
A
摘要:
目的 观察前列地尔辅助常规治疗冠心病不稳定型心绞痛 (UAP) 患者的临床效果及其对患者血管内皮损伤和凝血功能的影响。方法 选择我院2018年1月~4月收治的62例UAP患者，按照随机数字法分为研究组各对照组，各31例。对照组予以常规治疗，研究组在对照组的基础上联合前列地尔治疗。比较两组患者血浆ET、Hcy、纤维蛋白原（FIB）、D-二聚体、血清基质金属蛋白酶（MMP-2）、肿瘤坏死因子（TNF-ɑ）、白细胞介素（IL-6、IL-8）及高敏C反应蛋白（hs-CRP）水平。结果 治疗后，研究组血浆ET、Hcy以及血清MMP-9水平分别为（80.41±8.49）pg/ml、（13.91±1.58）μmol/L、（183.61±18.58）ng/ml，均低于对照组的（96.68±9.74）pg/ml、（16.26±1.74）μmol/L、（224.13±21.94）ng/ml，差异有统计学意义（P＜0.05）；研究组FIB和D-二聚体水平分别为（2.91±0.23）g/L、（0.36±0.08）mg/L，均低于对照组的（3.67±0.32）g/L、（0.63±0.09）mg/L，差异有统计学意义（P＜0.05）；研究组血清hs-CRP、TNF-ɑ、IL-6、IL-8水平分别为（2.58±0.31）mg/L、（2.46±0.17）μg/L、（76.21±7.49）ng/L、（16.21±1.69）ng/L，均低于对照组的（3.72±0.25）mg/L、（3.15±0.18）μg/L、（87.31±8.49）ng/L、（18.51±1.23）ng/L，差异有统计学意义（P＜0.05）。结论 UAP患者采用前列地尔辅助常规治疗可有效降低血管内皮损伤，缓解炎症反应，降低血液黏度，改善患者预后。
Abstract:
Objective To investigate the effect of alprostadil in the treatment of patients with unstable angina pectoris (UAP) and its effects on vascular endothelial injury and coagulation function. Methods 62 patients with UAP admitted to our hospital from January to April 2018 were enrolled.According to the random number method, the study group and the control group were divided into 31 cases. The control group received routine treatment, and the study group was treated with alprostadil on the basis of the control group. Plasma ET, Hcy, fibrinogen (FIB), D-dimer, serum matrix metalloproteinase (MMP-2), tumor necrosis factor (TNF-ɑ),Interleukin (IL-6,IL-8) and high-sensitivity C-reactive protein (hs-CRP) levels. Results After treatment, plasma ET, Hcy and serum MMP-9 levels in the study group were (80.41±8.49) pg/ml, (13.91±1.58) μmol/L, and (183.61±18.58) ng/ml, respectively, which were lower than the control group(96.68±9.74) pg/ml, (16.26±1.74) μmol/L, (224.13±21.94) ng/ml, the difference was statistically significant (P<0.05); the study group FIB and D-dimer levels were respectively (2.91±0.23) g/L, (0.36±0.08) mg/L, which were lower than (3.67±0.32) g/L and (0.63±0.09) mg/L in the control group, the difference was statistically significant (P<0.05); serum hs-CRP, TNF-ɑ, IL-6, IL-8 levels in the study group were (2.58±0.31) mg/L, (2.46±0.17) μg/L, (76.21±7.49) ng/L, (16.21±1.69) ng/L, were lower than the control group (3.72±0.25) mg/L, (3.15±0.18) μg/L,(87.31±8.49) ng/L,(18.51±1.23) ng/L, the difference was statistically significant (P<0.05). Conclusion The use of alprostadil in the UAP patients can effectively reduce vascular endothelial injury, relieve inflammation, reduce blood viscosity and improve patient prognosis.

参考文献/References:

[1]韩会来,尹红,吕国芬,等.前列地尔辅助介入术治疗不稳定型心绞痛的临床观察[J].解放军预防医学杂志,2018,36(1): 62-63. [2]张健维,高建军,刘德林,等.老年冠心病心绞痛患者急性发作期应用前列地尔的临床观察[J].中国处方药,2018,16(11):152-153. [3]李迎春.前列地尔注射液联合红花黄色素治疗冠心病不稳定性心绞痛的效果观察[J].河南医学研究,2018,13(1):2994-2996. [4]周衍国,麦瑞林,黄敏旋,等.前列地尔对冠心病患者血浆内皮素、同型半胱氨酸和凝血功能的影响[J].海南医学,2018,10(7):917-919. [5]王超,王利红,刘宝,等.前列地尔注射液对老年不稳定型心绞痛病人临床症状、心电图及血常规的影响[J].中西医结合心脑血管病杂志,2018,16(9):91-93. [6]徐丽萍.前列地尔注射液治疗冠心病心绞痛的临床疗效分析[J].中医临床研究,2018,10(12):54-55. [7]黄路梅.前列地尔注射液辅助治疗老年冠心病稳定型心绞痛的临床疗效[J].深圳中西医结合杂志,2017,23(2):82-84. [8]古东,林洁.麝香保心丸与前列地尔联合治疗冠心病心绞痛的临床研究[J].中外医学研究,2018,379(11):137-138. [9]马庆阳,周捷,饶友义.前列地尔联合通脉颗粒治疗不稳定型心绞痛的疗效及其血清IL-6、hs-CRP的变化分析[J].中国心血管病研究,2018,23(6):549-554. [10]汪亚峰.丹参酮注射液联合前列地尔注射液治疗冠心病心绞痛的临床疗效观察[J].临床医药文献电子杂志,2017,19(80):15804.

相似文献/References:

[1]袁 帅,邢晓博,李 晓,等.MTHFR基因多态性与中年男性冠状动脉病变程度的相关研究[J].医学信息,2018,31(03):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
　YUAN Shuai,XING Xiao-bo,LI Xiao,et al.Association of MTHFR Gene Polymorphism with Coronary Artery Lesions in Middle-aged Men[J].Journal of Medical Information,2018,31(20):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
[2]张挺挺.经股和桡动脉介入治疗冠心病的临床疗效对比[J].医学信息,2018,31(03):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
　ZHANG Ting-ting.Comparison of Clinical Effects of Interventional Treatment of Coronary Heart Disease by Femoral and Radial Artery[J].Journal of Medical Information,2018,31(20):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
[3]迮艳华.稳心颗粒联合美托洛尔治疗冠心病心律失常的疗效分析[J].医学信息,2018,31(03):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
　ZE Yan-hua.Therapeutic Effect of Wenxin Granule Combined with Metoprolol on Arrhythmia of Coronary Heart Disease[J].Journal of Medical Information,2018,31(20):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
[4]张 旭.冠心病心绞痛患者进行护理干预的临床效果及 对护理质量影响研究[J].医学信息,2018,31(05):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
　ZHANG Xu.Clinical Effect of Nursing Intervention in Patients with Angina Pectoris of Coronary Heart Disease and its Influence on Nursing Quality[J].Journal of Medical Information,2018,31(20):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
[5]向明明,赵晓辉.黑龙江省东部地区汉族人群冠心病的危险因素研究[J].医学信息,2018,31(07):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
　XIANG Ming-ming,ZHAO Xiao-hui.Study on Risk Factors of Coronary Heart Disease in Han Nationality Population in Eastern Heilongjiang Province[J].Journal of Medical Information,2018,31(20):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
[6]王 坤,张永春.血清胆红素水平、单核细胞数、红细胞分布宽度与 冠状动脉病变程度的关系[J].医学信息,2018,31(08):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
　WANG Kun,ZHANG Yong-chun.Relationship between Serum Bilirubin Level,Monocyte Count,Red Blood Cell Distribution Width and Severity of Coronary Artery Disease[J].Journal of Medical Information,2018,31(20):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
[7]毛红岩.冠状动脉介入治疗冠心病的疗效及 对患者血清炎症因子的影响[J].医学信息,2018,31(10):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
　MAO Hong-yan.Effect of Coronary Intervention on Coronary Heart Disease and its Influence on Serum Inflammatory Factors[J].Journal of Medical Information,2018,31(20):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
[8]杨锦龙,刘 欢,吕秋菊,等.非糖尿病患者糖化血红蛋白和胰岛素抵抗与 冠状动脉病变程度的相关性研究[J].医学信息,2018,31(10):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
　YANG Jin-long,LIU Huan,LV Qiu-ju,et al.Correlation between Glycosylated Hemoglobin and Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetic Patients[J].Journal of Medical Information,2018,31(20):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
[9]李 铎,王建华.盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响[J].医学信息,2018,31(10):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
　LI Duo,WANG Jian-hua.Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure[J].Journal of Medical Information,2018,31(20):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
[10]田跃雷.冠心病介入治疗后再狭窄的中西医防治[J].医学信息,2022,35(09):46.[doi:10.3969/j.issn.1006-1959.2022.09.011]
　TIAN Yue-lei.Prevention and Treatment of Restenosis After Percutaneous Coronary Intervention with Chinese and Western Medicine[J].Journal of Medical Information,2022,35(20):46.[doi:10.3969/j.issn.1006-1959.2022.09.011]

更新日期/Last Update: 2019-10-15