参考文献/References:
[1]赵辨.中国临床皮肤性病学[M].南京:江苏科学技术出版社,2017:1577-1578.
[2]Gauglitz GG,Korting HC,Pavicic T.Hypertrophic scarring and keloids: patho mechanisms and current and emerging treatment strategies[J].Mol Med,2011,17(1-2):113-125.
[3]夏照帆,吕开阳.中国临床瘢痕防治专家共识[J].中华损伤与修复杂志(电子版),2017,12(6):401-408.
[4]Lian N,Li T.Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications[J].Biomed Pharmacother,2016(84):42-50.
[5]Zhu Z,Ding J,Shankowsky HA.The molecular mechanism ofhypertrophic scar[J].Cell Commun Signal,2013,7(4):239-252.
[6]Kiritsi D,Nystr?觟m A.The role of TGFβ in wound healing pathologies[J].Mech Ageing Dev,2018(172):51-58.
[7]杨明.靶向调控TGFβ/smad通路中smad4蛋白对增生性瘢痕成纤维细胞的影响[D].昆明医科大学,2016.
[8]Kamato D,Do BH,Osman N.Smad linkerregion phosphorylation is a signalling pathway in its own right and not only amodulator of canonical TGF-β signalling[J].Cell Mol Life Sci,2019(2019):1-9.
[9]陈炎.TGF-β信号中R-Smads磷酸酶在宫颈癌发生发展过程中的表达及作用机制研究[D].安徽医科大学,2018.
[10]Pakyari M,Farrokhi A,Maharlooei MK.Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing[J].Adv Wound Care (New Rochelle),2013,2(5):215-224.
[11]Sun Q,Guo S,Wang CC.Cross-talk between TGF-β/Smad pathway and Wnt/β-catenin pathway in pathological scar formation[J].Clin Exp Pathol,2015,8(6):7631-7639.
[12]Xie JL,Qi SH,Pan S.Expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts in response to transforming growth factor beta1[J].Dermatol Surg,2008,34(9):1216-1224.
[13]Wei G,Xu Q,Liu L.LY2109761 reduces TGF-β1-induced collagen production and contraction in hypertrophic scar fibroblasts[J].Arch Dermatol Res,2018,310(8):615-623.
[14]Zhao D,Wang Y,Du C.Honokiol AlleviatesHypertrophic Scar by Targeting Transforming Growth Factor-β/Smad2/3 Signaling Pathway[J].Front Pharmacol,2017(8):206.
[15]王鹏.TGF-β1介导TGF-β1/Smad及ERK/MAPK通路协同促进大鼠骨髓炎瘢痕形成的机制研究[D].山东大学,2017.
[16]胡瑜.ERK1/2蛋白信号在BPD新生鼠肺成纤维细胞增殖、转化及迁移中作用的研究[D].中国医科大学,2018.
[17]陈伟,付小兵,葛世丽.增生性瘢痕形成和成熟过程中细胞外信号调节激酶基因表达的变化[J].中华创伤杂志,2004(1):48-49.
[18]Zhang X,Arnott JA,Rehman S.Src is a major signaling component for CTGF induction by TGF-beta1 inosteoblasts[J].Cell Physiol,2010,224(3):691-701.
[19]Cuadrado A,Nebreda AR.Mechanisms and functions of p38 MAPKsignalling[J].Biochem J,2010,429(3):403-417.
[20]Chen Z,Chen Y,Pan L.Dachengqi Decoction Attenuates Inflammatory Response via Inhibiting HMGB1 Mediated NF-κB and P38 MAPK Signaling Pathways in Severe Acute Pancreatitis[J].Cell Physiol Biochem,2015,37(4):1379-1789.
[21]孙金玲,郑金旭,史小东,等.柴胡皂甙D通过调控TGF-β1/Smads信号通路抑制人胚肺成纤维细胞增殖和胶原蛋白产生[J].细胞与分子免疫学杂志,2019,35(3):256-261.
[22]Du QC,Zhang DZ,Chen XJ.The effect of p38MAPK oncyclic stretch in human facial hypertrophic scar fibroblast differentiatio[J].PLoS One,2013,8(10):e75635.
[23]Chai CY,Song J,Tan Z.Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway[J].J Cell Biochem,2019,120(3):4057-4064.
[24]Li Y,Zhang W,Gao J.Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38/MAPK signaling pathway[J].Stem Cell Res Ther,2016,7(1):102.
[25]Sun Q,Guo S,Wang CC,et al.Cross-talk between TGF-β/Smad pathway and Wnt/β-catenin pathway in pathological scar formation[J].Int J Clin Exp Pathol,2015,8(6):7631-7639.
[26]Clark CE,Nourse CC,Cooper HM.The tangled web of non-canonical Wnt signalling in neural migration[J].Neurosignals,2012,20(3):202-220.
[27]张新,巨朝娟,张剑,等.形觉剥夺性近视模型大鼠巩膜成纤维细胞中TGF-β1表达及Wnt/β-catenin信号通路的调控作用[J].吉林大学学报(医学版),2019,45(4):861-866.
[28]Carre AL,Hu MS,James AW.β-Catenin-Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding[J].Plast Reconstr Surg,2018,141(3):669-678.
[29]刘佳琦.Wnt/β-catenin信号通路在TGF-β1诱导的真皮成纤维细胞向肌成纤维细胞表型转化中作用和机制的研究[D].第四军医大学,2012.
[30]何俊洲.PI3K/AKT信号通路在骨结核发病中骨破坏机制的研究[D].贵州医科大学,2016.
[31]赵滢,高立红,王楠,等.S100A4基因沉默对人胃癌细胞中PI3K/AKT/mTOR信号通路及VEGF表达的影响[J].解剖科学进展,2018,24(4):354-356.
[32]White ES,Sagana RL,Booth AJ.Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway[J].Exp Cell Res,2010,316(16):2644-2253.
[33]Zhai XX,Tang ZM,Ding JC.Expression of TGF-β1/mTOR signaling pathway in pathological scar fibroblasts[J].Mol Med Rep,2017,15(6):3467-3472.
[34]Huang S,Yang C,Li M.Effect of dual mTOR inhibitor on TGFβ1-induced fibrosis in primary human urethral scar fibroblasts[J].Biomed Pharmacother,2018(106):1182-1187.
[35]Harvey KF,Zhang X,Thomas DM.The Hippo pathway and human cancer[J].Nat Rev Cancer,2013,13(4):246-257.
[36]张丽.Hippo信号通路在病理性瘢痕发生机制中作用研究[D].扬州大学,2017.
[37]Piccolo S,Dupont S,Cordenonsi M.The biology of YAP/TAZ: hippo signaling and beyond[J].Physiol Rev,2014,94(4):1287-1312.
[38]Liu F,Lagares D,Choi KM.Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis[J].Am J Physiol Lung Cell Mol Physiol,2015,308(4):L344-L357.
[39]张曼,李均.Notch和TGF信号通路对话在肾间质纤维化的研究[J].临床肾脏病杂志,2019(9):705-709.
[40]姚卫君. Notch1蛋白在正常皮肤、增生性瘢痕及皮肤瘢痕癌中的表达[D].郑州大学,2018.
[41]Kim JE,Lee JH,Jeong KH.Notch intracellular domainexpression in various skin fibroproliferative diseases[J].Ann Dermatol,2014,26(3):332-337.
[42]Li B,Gao C,Diao JS.Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes[J].Exp Dermatol,2016,25(2):137-142.
[43]Wang P,Shu B,Xu Y.Basic fibroblast growth factor reduces scar by inhibiting thedifferentiation of epidermal stem cells to myofibroblasts via the Notch1/Jagged1 pathway[J].Stem Cell Res Ther,2017,8(1):114.
[44]Syed IS,Pedram A,Farhat WA.Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis[J].Curr Urol Rep,2016,17(2):11.
[45]Fink DM,Sun MR,Heyne GW.Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway[J].Cell Signal,2018(44):1-9.
[46]Bohm M,Stegemann A.Bleomycin-induced fibrosis in MC1 signalling-deficient C57BL/6J-Mc1r(e/e) mice further supports a modulating role for melanocortins in collagen synthesis of the skin[J].Exp Dermatol,2014,23(6):431-433.
相似文献/References:
[1]张益勋,胡逸萍,钟穗航,等.DNA甲基化在病理性瘢痕中的作用研究[J].医学信息,2018,31(09):46.[doi:10.3969/j.issn.1006-1959.2018.09.015]
ZHANG Yi-xun,HU Yi-ping,ZHONG Sui-hang,et al.Study on the Role of DNA Methylation in Pathological Scars[J].Journal of Medical Information,2018,31(22):46.[doi:10.3969/j.issn.1006-1959.2018.09.015]
[2]杜雅静,王宇意,章丹婷,等.研磨珠均质仪提取增生性瘢痕组织蛋白质的方法[J].医学信息,2018,31(15):51.[doi:10.3969/j.issn.1006-1959.2018.15.017]
DU Ya-jing,WANG Yu-yi,ZHANG Dan-ting,et al.Method for Extracting Hyperplastic Scar Tissue Protein by Grinding Bead Homogenizer[J].Journal of Medical Information,2018,31(22):51.[doi:10.3969/j.issn.1006-1959.2018.15.017]
[3]朱伟东,王富生,王志远.瘢痕组织中胶原蛋白提取及纯化研究[J].医学信息,2018,31(17):84.[doi:10.3969/j.issn.1006-1959.2018.17.025]
ZHU Wei-dong,WANG Fu-sheng,WANG Zhi-yuan.Extraction and Purification of Collagen from Scar Tissue[J].Journal of Medical Information,2018,31(22):84.[doi:10.3969/j.issn.1006-1959.2018.17.025]
[4]蔡润智,谢有富,何飘飘,等.HIF-1α在病理性瘢痕中的作用研究[J].医学信息,2021,34(04):57.[doi:10.3969/j.issn.1006-1959.2021.04.015]
CAI Run-zhi,XIE You-fu,HE Piao-piao,et al.Study on the Role of HIF-1α in Pathological Scars[J].Journal of Medical Information,2021,34(22):57.[doi:10.3969/j.issn.1006-1959.2021.04.015]