[1]闫雪波,王 炯.RKIP在不同类型肺癌中表达的变化及临床意义[J].医学信息,2019,32(22):55-58.[doi:10.3969/j.issn.1006-1959.2019.22.018]
　YAN Xue-bo,WANG Jiong.Changes of RKIP Expression in Different Types of Lung Cancer and Its Clinical Significance[J].Journal of Medical Information,2019,32(22):55-58.[doi:10.3969/j.issn.1006-1959.2019.22.018]
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RKIP在不同类型肺癌中表达的变化及临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年22期
页码:
55-58
栏目:
论著
出版日期:
2019-11-15

文章信息/Info

Title:
Changes of RKIP Expression in Different Types of Lung Cancer and Its Clinical Significance
文章编号:
1006-1959（2019）22-0055-04
作者:
闫雪波; 王 炯
（安徽医科大学第一附属医院干部呼吸与危重医学科，安徽 合肥 230022）
Author(s):
YAN Xue-bo; WANG Jiong
(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)
关键词:
RKIP; ERK1/2; 肺癌; 腺癌; 癌症分期
Keywords:
RKIP; ERK1/2; Lung cancer; Adenocarcinoma; Cancer staging
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2019.22.018
文献标志码:
A
摘要:
目的 观察Raf激酶抑制蛋白（RKIP）在不同类型肺癌中表达的变化及探讨其临床价值。方法 选取鳞癌21例、腺癌23例及小细胞肺癌10例设为实验组，肺良性病变10例设为对照组，采用免疫组化的方法检测RKIP的表达，观察在不同类型肺癌中表达的差异及与临床分期的关系。结果 与对照组比较，实验组中RKIP的表达水平均降低，差异有统计学意义（P＜0.05）。实验组中RKIP的表达最低的是小细胞癌，其次为鳞癌，再次腺癌。对腺癌进一步研究发现，与Ⅰ及Ⅱ期比较，RKIP在Ⅲ及Ⅳ期的表达更低；与Ⅰ期比较，RKIP在Ⅱ期中表达稍有减低，但差异无统计学意义（P＞0.05）；与Ⅲ期比较，RKIP在Ⅳ期中表达稍有减低，但差异无统计学意义（P＞0.05）。磷酸化ERK1/2（p-ERK1/2）的表达趋势与RKIP相反，与Ⅰ和Ⅱ期比较，在Ⅲ和Ⅳ期中表达明显升高。相关性分析显示，RKIP与p-ERK1/2的表达呈负相关（r=-0.893，P＜0.05）。结论 RKIP表达水平的缺失可能促进了ERK1/2的磷酸化，从而促进了肺癌的发生及发展，因此检测RKIP的表达水平可能对诊断肺癌及分期预后有重要的临床价值。
Abstract:
Objective To observe the changes of expression of Raf kinase inhibitory protein (RKIP) in different types of lung cancer and to explore its clinical value. Methods 21 cases of squamous cell carcinoma, 23 cases of adenocarcinoma and 10 cases of small cell lung cancer were selected as experimental group. 10 cases of benign lung lesions were used as control group. The expression of RKIP was detected by immunohistochemistry and observed in different types of lung cancer. Differences and relationships with clinical staging. Results Compared with the control group, the expression level of RKIP in the experimental group decreased,the difference was statistically significant (P<0.05). The lowest expression of RKIP in the experimental group was small cell carcinoma, followed by squamous cell carcinoma and re-adenocarcinoma. Further studies on adenocarcinoma found that RKIP was lower in stage III and IV than stage I and stage II. Compared with stage I, RKIP was slightly decreased in stage II, but the difference was not statistically significant (P>0.05). Compared with stage III, RKIP expression was slightly decreased in stage IV, but the difference was not statistically significant (P>0.05). The expression trend of phosphorylated ERK1/2 (p-ERK1/2) was opposite to that of RKIP, and the expression was significantly increased in stages III and IV compared with stage I and II. Correlation analysis showed that RKIP was negatively correlated with p-ERK1/2 expression (r=-0.893, P<0.05). Conclusion The loss of RKIP expression may promote the phosphorylation of ERK1/2, which promotes the occurrence and development of lung cancer. Therefore, the detection of RKIP expression may have important clinical value in the diagnosis of lung cancer and staged prognosis.

参考文献/References:

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更新日期/Last Update: 2019-11-15