[1]黄庆松,马爱玲,张 瑞,等.合并微出血对脑小血管闭塞性卒中患者认知功能的影响及其与P300的关系[J].医学信息,2019,32(22):66-68,78.[doi:10.3969/j.issn.1006-1959.2019.22.021]
　HUANG Qing-song,MA Ai-ling,ZHANG Rui,et al.Effect of Combined Microbleeds on Cognitive Function in Patients with Cerebral Small Vessel Occlusive Stroke and Its Relationship with P300[J].Journal of Medical Information,2019,32(22):66-68,78.[doi:10.3969/j.issn.1006-1959.2019.22.021]
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合并微出血对脑小血管闭塞性卒中患者认知功能的影响及其与P300的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年22期
页码:
66-68,78
栏目:
论著
出版日期:
2019-11-15

文章信息/Info

Title:
Effect of Combined Microbleeds on Cognitive Function in Patients with Cerebral Small Vessel Occlusive Stroke and Its Relationship with P300
文章编号:
1006-1959（2019）22-0066-04
作者:
黄庆松; 马爱玲; 张 瑞; 万浩鹏; 李化强
（上海市嘉定区中医医院脑病科，上海 201800）
Author(s):
HUANG Qing-song; MA Ai-ling; ZHANG Rui; WAN Hao-peng; LI Hua-qiang
(Department of Encephalopathy,Jiading District Traditional Chinese Medicine Hospital,Shanghai 201800,China)
关键词:
小血管闭塞性卒中; 脑微出血; 认知功能; P300
Keywords:
Small vessel occlusive stroke; Cerebral microbleeds; Cognitive function; P300
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2019.22.021
文献标志码:
A
摘要:
目的 探讨合并微出血（CMBs）对脑小动脉闭塞性卒中（SAO）患者认知功能的影响及与事件相关电位（ERP）P300的相关性。方法 选取本院2017年12月~2019年4月脑病科SAO患者70例作为研究对象，应用蒙特利尔认知评估量表（MoCA）进行认知功能评估。应用1.5T超导磁共振对所有患者进行常规序列及磁敏感（SWI）序列检查，分析SAO患者认知功能损伤与CMBs的关系。采用Keypoint诱发电位仪检测P300电位，分析SAO患者CMBs与P300电位关系。结果 本研究最终纳入70例SAO患者，其中MoCA总分异常者48例，MoCA总分正常者22 例。年龄、教育年限、高血压病史、白质疏松程度和CMBs的有无与SAO患者MoCA评分异常有关（P＜0.05）。Logistic回归分析发现，CMBs的有无（OR=5.648，95%CI=1.105~28.869，P=0.038）仍然是MoCA评分异常的独立危险因素。微出血（CMBs）组 MoCA总分降低，P300潜伏期显著延长、波幅明显降低，差异均有统计学意义（P＜0.05）。CMBs程度与P300潜伏期相关Pz（r=0.252，P＜0.05）；Cz（r=0.296，P＜0.05）。结论 CMBs与SAO患者认知功能损伤相关，伴CMBs的SAO患者P300电位有明显改变，P300可作为评估SAO合并CMBs患者的认知功能障碍的客观指标之一。
Abstract:
Objective To investigate the effects of combined microbleeds (CMBs) on cognitive function in patients with cerebral small artery occlusion stroke (SAO) and its correlation with event-related potential (ERP) P300. Methods 70 patients with SAO in encephalopathy from December 2017 to April 2019 in our hospital were selected as subjects, and the cognitive function assessment was performed using the Montreal Cognitive Assessment Scale (MoCA). Routine sequence and magnetic susceptibility (SWI) sequence examinations were performed in all patients with 1.5T superconducting magnetic resonance to analyze the relationship between cognitive impairment and CMBs in SAO patients. The P300 potential was detected by Keypoint evoked potential meter, and the relationship between CMBs and P300 potential in SAO patients was analyzed.Results The study included 70 patients with SAO, including 48 patients with abnormal MoCA scores and 22 patients with normal MoCA scores. Age, years of education, history of hypertension, degree of white matter loosening, and presence or absence of CMBs were associated with abnormal MoCA scores in SAO patients (P<0.05). Logistic regression analysis found that the presence or absence of CMBs (OR=5.648, 95% CI=1.105~28.869, P=0.038) remained an independent risk factor for abnormal MoCA scores. In the micro-bleeding (CMBs) group, the total score of MoCA decreased, the latency of P300 was significantly prolonged, and the amplitude was significantly decreased,the difference was statistically significant (P<0.05).The degree of CMBs is related to the latency of P300 Pz(r=0.252, P<0.05); Cz (r=0.296, P<0.05).Conclusion CMBs are associated with cognitive impairment in SAO patients, and P300 potential in SAO patients with CMBs is significantly altered. P300 can be used as an objective indicator for assessing cognitive dysfunction in patients with SAO and CMBs.

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更新日期/Last Update: 2019-11-15