[1]张志颖.老年女性内源性循环雌二醇和卒中风险的研究[J].医学信息,2019,32(22):84-86.[doi:10.3969/j.issn.1006-1959.2019.22.025]
　ZHANG Zhi-ying.Study on Endogenous Circulating Estradiol and Stroke Risk in Elderly Women[J].Journal of Medical Information,2019,32(22):84-86.[doi:10.3969/j.issn.1006-1959.2019.22.025]
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老年女性内源性循环雌二醇和卒中风险的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年22期
页码:
84-86
栏目:
论著
出版日期:
2019-11-15

文章信息/Info

Title:
Study on Endogenous Circulating Estradiol and Stroke Risk in Elderly Women
文章编号:
1006-1959（2019）22-0084-03
作者:
张志颖
（天津市武清区人民医院神经内科，天津 301700）
Author(s):
ZHANG Zhi-ying
(Department of Neurology,People's Hospital of Wuqing District,Tianjin 301700,China)
关键词:
老年女性; 缺血性脑卒中; 内源性循环雌二醇
Keywords:
Elderly women; Ischemic stroke; Endogenous circulating estradiol
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2019.22.025
文献标志码:
A
摘要:
目的 探讨老年女性内源性循环雌二醇和卒中（IS）风险的关系。方法 选择2018年1月~2019年3月在我院就诊的131例老年女性IS患者设为IS组，按1∶1比例收集同期在我院就诊的不伴卒中的动脉粥样硬化患者设为AS组，同法收集同期在我院体检的老年女性作为对照组（C组），采用单因素和多因素分析循环游离雌二醇（E2）和性激素结合球蛋白（SHBG）与IS的关系。结果 三组年龄、吸烟史、糖尿病、高血压、心绞痛、心肌梗死史、阿司匹林服用、TC、TG、LDL-C、HDL-C、TC/HDL-C、CRP、Hcy、E2、SHBG比较，差异有统计学意义（P＜0.05），三组绝经年龄、体质量指数、目前吸烟、每周饮酒次数、规律煅炼、雌激素应用史比较，差异无统计学意义（P＞0.05）。Logistic分析结果显示，年龄＞72岁、糖尿病、LDL-C＞154.2 mg/dl、CRP＞0.52 mg/dl、E2＞36.3 pg/ml、SHBG＜37.7 μg/ml是影响IS发生的因素（P＜0.05）。结论 内源性雌二醇水平是老年绝经后女性IS风险增加的因素，降低雌二醇水平或应用其拮抗药物对高内源性雌激素女性IS的预防可能有益，值得进一步研究探讨。
Abstract:
Objective To investigate the relationship between endogenous circulating estradiol and stroke (IS) risk in elderly women. Methods A total of 131 elderly women with IS in our hospital from January 2018 to March 2019 were enrolled in the IS group. The atherosclerotic patients who were not treated with stroke in our hospital were collected at a ratio of 1:1. In the AS group, the same method was used to collect the elderly women who were in our hospital for the same period as the control group (group C). The relationship between circulating free estradiol (E2) and sex hormone binding globulin (SHBG) and IS was analyzed by single factor and multivariate analysis. Results Three groups of age, smoking history, diabetes, hypertension, angina pectoris, history of myocardial infarction, aspirin, TC, TG, LDL-C, HDL-C, TC/HDL-C, CRP, Hcy, E2, SHBG,the difference was statistically significant (P<0.05). There were no significant differences in the three groups of menopausal age, body mass index, current smoking, weekly drinking times, regular calcination, and estrogen application history (P>0.05). Logistic analysis showed that age >72 years, diabetes, LDL-C>154.2 mg/dl, CRP>0.52 mg/dl, E2>36.3 pg/ml, and SHBG<37.7 μg/ml were factors affecting IS (P<0.05). Conclusion The level of endogenous estradiol is an increasing risk of IS in postmenopausal women. Decreasing the level of estradiol or using its antagonistic drugs may be beneficial for the prevention of IS in women with high endogenous estrogen. It is worthy of further study.

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更新日期/Last Update: 2019-11-15