[1]刘书斌,刘云庚,陈财福,等.低剂量mFOLFOX6联合同步三维适形放疗在T3期直肠癌术前治疗中的可行性[J].医学信息,2019,32(22):109-111.[doi:10.3969/j.issn.1006-1959.2019.22.035]
　LIU Shu-bin,LIU Yun-geng,CHEN Cai-fu,et al.Feasibility of Low-dose mFOLFOX6 Combined with Synchronous Three-dimensional Conformal Radiotherapy for Preoperative Treatment of Rectal Cancer in Stage T3[J].Journal of Medical Information,2019,32(22):109-111.[doi:10.3969/j.issn.1006-1959.2019.22.035]
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低剂量mFOLFOX6联合同步三维适形放疗在T3期直肠癌术前治疗中的可行性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年22期
页码:
109-111
栏目:
临床研究
出版日期:
2019-11-15

文章信息/Info

Title:
Feasibility of Low-dose mFOLFOX6 Combined with Synchronous Three-dimensional Conformal Radiotherapy for Preoperative Treatment of Rectal Cancer in Stage T3
文章编号:
1006-1959（2019）22-0109-03
作者:
刘书斌1; 刘云庚2; 陈财福1; 易建中2; 赖景春1
（江西省赣州市人民医院肿瘤科1，胃肠外科2，江西 赣州 341000）
Author(s):
LIU Shu-bin1; LIU Yun-geng2; CHEN Cai-fu1; YI Jian-zhong2; LAI Jing-chun1
(Department of Oncology1,Department of Gastrointestinal Surgery2,People's Hospital of Ganzhou City,Ganzhou 341000,Jiangxi,China)
关键词:
低剂量; mFPLFOX6; 三维适形放疗; T3期直肠癌
Keywords:
Low dose; mFPLFOX6; Three-dimensional conformal radiotherapy; T3 rectal cancer
分类号:
R735.3+7
DOI:
10.3969/j.issn.1006-1959.2019.22.035
文献标志码:
A
摘要:
目的 探讨低剂量mFPLFOX6联合同步三维适形放疗治疗在T3期直肠癌术前治疗中的可行性。方法 选取2016年1月~2018年10月我院收治的T3期中低位直肠癌患者80例，均予以低剂量mFPLFOX6方案同步三维适形放疗治疗，在治疗结束8周后行全直肠系膜切除术，分析患者放化疗期间毒性反应发生情况、围术期并发症以及手术情况，并评估患者化疗后T、N降期情况。结果 所有患者均未出现3级、4级血液学毒性，仅有2例出现放射性皮炎和1例腹泻的3级非血液学毒性，发生率分别为2.50%和1.25%。治疗后，有24例患者T、N同时降期，降期率为30.00%；有49例患者T分期下降，降期率为61.25%；有43例患者N分期下降，降期率为53.75%。围术期并发症发生率为7.50%；保肛率为81.25%、远处转移率为3.75%。结论 术前低剂量mFPLFOX6联合同步三维适形放疗能够减少毒性反应发生，有助于T3期直肠癌患者T、N降期，提高保肛率，安全可靠。
Abstract:
Objective To investigate the feasibility of low-dose mFPLFOX6 combined with three-dimensional conformal radiotherapy in the preoperative treatment of rectal cancer in stage T3. Methods 80 patients with moderate to low rectal cancer of T3 who were admitted to our hospital from January 2016 to October 2018 were enrolled in this study. All patients were treated with low-dose mFPLFOX6 synchronous three-dimensional conformal radiotherapy. Total mesorectal excision was performed 8 weeks after the end of treatment. The incidence of toxicity, perioperative complications and surgery during radiotherapy and chemotherapy, and assess the T and N decline after chemotherapy. Results There were no grade 3 or 4 hematologic toxicity in all patients, only 2 cases of radiation dermatitis and 1 case of diarrhea with grade 3 non-hematologic toxicity, with incidence rates of 2.50% and 1.25%, respectively. After treatment, 24 patients with T and N decreased at the same time, the rate of decline was 30.00%; 49 patients with T stage decreased, the rate of decline was 61.25%; 43 patients with N stage decreased, the rate of decline was 53.75% . The perioperative complication rate was 7.50%; the anal sphincter rate was 81.25%, and the distant metastasis rate was 3.75%. Conclusion Preoperative low-dose mFPLFOX6 combined with synchronous three-dimensional conformal radiotherapy can reduce the occurrence of toxicity, help T and N in patients with T3 rectal cancer, and improve the rate of anal sphincm. It is safe and reliable.

参考文献/References:

[1]龙成,李国权,姜永梅.三维适形放疗同步奥沙利铂加卡培他滨术前治疗Ⅱ~Ⅲ期直肠癌的疗效观察[J].临床肿瘤学杂志,2015,20(10):918-921. [2]蔡艳萍,薛顺和.志苓胶囊联合mFOLFOX6方案用于初治老年晚期直肠癌疗效及其安全性观察[J].世界中医药,2017,12(10):2343-2346. [3]冯燕茹.Ⅱ/Ⅲ期直肠癌根治术后同步放化疗疗效及预后分析[D].北京协和医学院,2016. [4]Farhan F,Fazeli MS,Samiei F,et al.Morbidity and Mortality Following Short Course Preoperative Radiotherapy in Rectal Carcinoma[J].Acta Medica Iranica,2015,53(10):627-632. [5]李蓉蓉,殷先利,刘振洋,等.XELOX方案和mFOLFOX6方案治疗结直肠癌的临床疗效与安全性分析[J].现代中西医结合杂志,2016,25(36):4069-4070. [6]李敏,方明治.健脾补肾方联合mFolfox6方案治疗结直肠癌的疗效观察[J].中医药导报,2015,21(24):26-28. [7]卢宁宁,金晶,李晔雄,等.Ⅱ期和Ⅲ期直肠癌根治术后卡培他滨同期放化疗疗效及失败原因分析[J].中华放射肿瘤学杂志,2011,20(6):497-501. [8]Gérard JP,Conroy T,Bonnetain F,et al.Preoperative Radiotherapy With or Without Concurrent Fluorouracil and Leucovorin in T3-4 Rectal Cancers:Results of FFCD 9203[J].Journal of Clinical Oncology,2006,24(28):4620-4625. [9]朱卫国,尤振兵,韩济华,等.术前三维适形放射治疗并希罗达治疗局部晚期直肠癌的疗效[J].实用医学杂志,2009,25(06):967-969.

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更新日期/Last Update: 2019-11-15