[1]曹 璐.机采血小板联合冷沉淀输注对颅脑外伤大出血患者凝血功能的影响[J].医学信息,2020,33(01):113-114.[doi:10.3969/j.issn.1006-1959.2020.01.034]
　CAO Lu.Effect of Mechanical Platelet Collection Combined with Cold Precipitation Infusion on Coagulation Function in Patients with Craniocerebral Trauma[J].Medical Information,2020,33(01):113-114.[doi:10.3969/j.issn.1006-1959.2020.01.034]
点击复制

机采血小板联合冷沉淀输注对颅脑外伤大出血患者凝血功能的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年01期
页码:
113-114
栏目:
临床研究
出版日期:
2020-01-01

文章信息/Info

Title:
Effect of Mechanical Platelet Collection Combined with Cold Precipitation Infusion on Coagulation Function in Patients with Craniocerebral Trauma
文章编号:
1006-1959（2020）01-0113-02
作者:
曹 璐
（天津医科大学第二医院输血科，天津 300000）
Author(s):
CAO Lu
(Department of Blood Transfusion,the Second Hospital of Tianjin Medical University,Tianjin 300000,China)
关键词:
颅脑外伤; 凝血功能; 血小板; 冷沉淀
Keywords:
Craniocerebral trauma; Coagulation function; Platelets; Cold precipitation
分类号:
R45；R73
DOI:
10.3969/j.issn.1006-1959.2020.01.034
文献标志码:
A
摘要:
目的 探讨机采血小板联合冷沉淀输注对颅脑外伤大出血患者凝血功能的影响。方法 选取2017年1月~2018年10月我院收治的90例重型颅脑外伤患者，随机分为A、B、C三组，各30例。A组输注血小板治疗，B组输注冷沉淀治疗，C组输注血小板和冷沉淀治疗。比较三组输注血制品前后的凝血功能变化。结果 输注前1 h三组血小板（Plt）、纤维蛋白原（FIB）、凝血酶时间（TT）、活化部分凝血酶原时间（APTT）、凝血酶原时间（PT）比较，差异无统计学意义（P＞0.05）；输注24 h后三组Plt、FIB均高于输注前1 h，TT、APTT、PT均低于输注前1 h，且C组PLT、TT、APTT、PT优于A组、B组，差异均有统计学意义（P＜0.05）。结论 对于颅脑外伤大出血患者，联合输注血小板和冷沉淀对其凝血功能的改善优于单独输注血小板和冷沉淀。
Abstract:
Objective To investigate the effect of platelet harvesting combined with cryoprecipitation infusion on coagulation function in patients with craniocerebral trauma. Methods 90 patients with severe craniocerebral trauma admitted in our hospital from January 2017 to October 2018 were randomly divided into groups A, B and C, with 30 cases in each group. Platelet transfusion treatment was used in group A, cryoprecipitation treatment was infused in group B, and platelet and cryoprecipitation treatment were infused in group C. The changes of blood coagulation function before and after blood transfusion were compared among the three groups. Results There were no significant differences in platelet (Plt), fibrinogen (FIB), thrombin time (TT), activated partial thrombin time (APTT), and prothrombin time (PT) between the three groups 1 h before infusion. (P＞0.05); after 24 h of infusion, the Plt and FIB of the three groups were higher than 1 h before the infusion, and TT, APTT, and PT were lower than 1 hour before the infusion,the PLT, TT, APTT, and PT in group C were better than those in group A and B,the differences were statistically significant(P<0.05).Conclusion For patients with craniocerebral trauma hemorrhage, the combination of platelet transfusion and cryoprecipitation can improve the coagulation function better than platelet transfusion and cryoprecipitation alone.

参考文献/References:

[1]燕备战,张洪亮,吴睿,等.颅脑外伤患者术中成分输血量评估[J].中国实用神经疾病杂志,2017,3(20):36-38. [2]梁利芳.机采血小板联合冷沉淀输注对大出血患者凝血功能的影响[J].医药论坛杂志,2018,7(39):156-157. [3]Wu XH,Shi XY,Gan JX,et al.Dynamically monitoring tissue factor and tissue factor pathway inhibior following secondary brain injury[J].Chin J Traumatol,2003(6):114. [4]周立田,杨平来,丁俊宏,等.早期应用重组活化凝血因子Ⅶ对重型颅脑外伤的临床疗效[J].临床神经外科杂志,2017,14(5):374-377. [5]Laroche M,Kucher ME,Huang MC,et al.Coagulophy after traumatic brain injury[J].Neurosurgery,2012(70):1334.

相似文献/References:

[1]刘方睿,余泽波.血栓弹力图对肝病患者凝血功能的评估及输血指导研究进展[J].医学信息,2018,31(08):42.[doi:10.3969/j.issn.1006-1959.2018.08.014]
　LIU Fang-rui,YU Ze-bo.Evaluation of Blood Coagulation in Patients with Liver Disease by Thromboelastogram and Research Progress on Blood Transfusion[J].Medical Information,2018,31(01):42.[doi:10.3969/j.issn.1006-1959.2018.08.014]
[2]金 英.维甲酸联合亚砷酸治疗急性早幼粒细胞白血病的疗效及对患者血清TAT、TM、PIC水平的影响[J].医学信息,2022,35(10):126.[doi:10.3969/j.issn.1006-1959.2022.10.030]
　JIN Ying.The Curative Effect of Retinoic Acid Combined with Arsenic Acid in the Treatment of Acute Promyelocytic Leukemia and its Effect on Serum TAT, TM and PIC Levels[J].Medical Information,2022,35(01):126.[doi:10.3969/j.issn.1006-1959.2022.10.030]
[3]赵文斌,张银善,张大春,等.早期气管切开术在颅脑外伤和脑出血治疗中的效果观察[J].医学信息,2018,31(18):80.[doi:10.3969/j.issn.1006-1959.2018.18.024]
　ZHAO Wen-bin,ZHANG Yin-shan,ZHANG Da-chun,et al.Effect of Early Tracheotomy on the Treatment of Craniocerebral Trauma and Cerebral Hemorrhage[J].Medical Information,2018,31(01):80.[doi:10.3969/j.issn.1006-1959.2018.18.024]
[4]张恺悦,陈幼琼.乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究[J].医学信息,2019,32(04):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
　ZHANG Kai-yue,CHEN You-qiong.Effect of Ulinastatin Combined with Xuebijing on Coagulation Function and Systemic Inflammatory Response in Patients with Sepsis after Burn[J].Medical Information,2019,32(01):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
[5]陈志萍.阿托伐他汀联合低分子肝素治疗短暂性脑缺血临床疗效[J].医学信息,2019,32(09):153.[doi:10.3969/j.issn.1006-1959.2019.09.051]
　CHEN Zhi-ping.Clinical Efficacy of Atorvastatin Combined with Low Molecular Weight Heparin in the Treatment of Transient Cerebral Ischemia[J].Medical Information,2019,32(01):153.[doi:10.3969/j.issn.1006-1959.2019.09.051]
[6]刘革铭,马洪俊,刘 毅,等.紫杉醇药物涂层球囊治疗急性心肌梗死的临床疗效及对患者术后凝血状态的影响[J].医学信息,2022,35(14):113.[doi:10.3969/j.issn.1006-1959.2022.14.027]
　LIU Ge-ming,MA Hong-jun,LIU Yi,et al.The Clinical Efficacy of Paclitaxel Drug Coated Balloon in the Treatment of Acute Myocardial Infarction and its Influence on Postoperative Coagulation State of Patients[J].Medical Information,2022,35(01):113.[doi:10.3969/j.issn.1006-1959.2022.14.027]
[7]吴 飞,余 路.尿毒清颗粒及前列地尔联合丹参酮治疗糖尿病肾病的疗效[J].医学信息,2019,32(13):153.[doi:10.3969/j.issn.1006-1959.2019.13.048]
　WU Fei,YU Lu.Therapeutic Effect of Urinary Granules and Alprostadil Combined with Tanshinone on Diabetic Nephropathy[J].Medical Information,2019,32(01):153.[doi:10.3969/j.issn.1006-1959.2019.13.048]
[8]关利平,李建文.凝血相关指标与乳腺癌新辅助化疗疗效预测的相关性研究[J].医学信息,2022,35(16):159.[doi:10.3969/j.issn.1006-1959.2022.16.041]
　GUAN Li-ping,LI Jian-wen.Study on Correlation Between Coagulation- related Indexes and Efficacy Prediction of Neoadjuvant Chemotherapy for Breast Cancer[J].Medical Information,2022,35(01):159.[doi:10.3969/j.issn.1006-1959.2022.16.041]
[9]胡可纯,张强惠子,刘海飞,等.抗凝药物预防PICC导管相关性血栓形成的Meta分析[J].医学信息,2023,36(19):23.[doi:10.3969/j.issn.1006-1959.2023.19.006]
　HU Ke-chun,ZHANG Qiang-hui-zi,LIU Hai-fei,et al.Meta-analysis of Anticoagulant Drugs for Prevention of PICC Catheter-related Thrombosis[J].Medical Information,2023,36(01):23.[doi:10.3969/j.issn.1006-1959.2023.19.006]
[10]潘 玲,刘玲玲,苏卫东.常规凝血功能指标与血栓弹力图在患者凝血功能检测中的对比研究[J].医学信息,2022,35(17):141.[doi:10.3969/j.issn.1006-1959.2022.17.039]
　PAN Ling,LIU Ling-ling,SU Wei-dong.Comparison of Thromboelastography and Conventional Coagulation in the Detection of Coagulation Function in Patients[J].Medical Information,2022,35(01):141.[doi:10.3969/j.issn.1006-1959.2022.17.039]

更新日期/Last Update: 2020-01-01