[1]陈冀远.右美托咪啶对脓毒症急性肾损伤患者肾功能及血管紧张素Ⅱ表达的影响[J].医学信息,2020,33(01):142-143.[doi:10.3969/j.issn.1006-1959.2020.01.045]
　CHEN Ji-yuan.Effect of Dexmedetomidine on Renal Function and Angiotensin Ⅱ Expression in Patients with Acute Renal Injury in Sepsis[J].Medical Information,2020,33(01):142-143.[doi:10.3969/j.issn.1006-1959.2020.01.045]
点击复制

右美托咪啶对脓毒症急性肾损伤患者肾功能及血管紧张素Ⅱ表达的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年01期
页码:
142-143
栏目:
药物与临床
出版日期:
2020-01-01

文章信息/Info

Title:
Effect of Dexmedetomidine on Renal Function and Angiotensin Ⅱ Expression in Patients with Acute Renal Injury in Sepsis
文章编号:
1006-1959（2020）01-0142-02
作者:
陈冀远
（河南省西峡县人民医院肾内科，河南 西峡 474500）
Author(s):
CHEN Ji-yuan
(Department of Nephrology,Xixia County People’s Hospital,Xixia 474500,Henan,China)
关键词:
右美托咪啶; 脓毒症; 急性肾损伤; 肾功能; 血管紧张素
Keywords:
Dexmedetomidine; Sepsis; Acute kidney injury; Renal function; Angiotensin
分类号:
R459.7；R692.5
DOI:
10.3969/j.issn.1006-1959.2020.01.045
文献标志码:
A
摘要:
目的 分析右美托咪啶对脓毒症急性肾损伤患者肾功能及血管紧张素Ⅱ表达的影响。方法 选择2018年3月~2019年3月在我院诊治的脓毒症急性肾损伤患者96例，随机分为对照组和观察组，各48例。对照组采用常规对症治疗，观察组在对照组基础上采用右美托咪啶治疗。比较两组临床肾功能指标[血肌酐（Scr）、尿素氮（BUN）、血清胱抑素C（Cys C）、尿24h肌酐清除率（24h Ccr）]、血管紧张素Ⅱ（Ang Ⅱ）。结果 治疗后两组Scr、BUN、Cys C均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；治疗后两组24h Ccr高于治疗前，且观察组高于对照组，差异有统计学意义（P＜0.05）；治疗后两组AngⅡ均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）。结论 右美托咪啶治疗脓毒症急性肾损伤，可有效保护肾功能，减少AngⅡ表达，进一步减轻AngⅡ导致的相关损伤。
Abstract:
Objective To analyze the effects of dexmedetomidine on renal function and angiotensin Ⅱ expression in patients with acute kidney injury in sepsis. Methods A total of 96 patients with acute kidney injury with sepsis diagnosed and treated in our hospital from March 2018 to March 2019 were selected and randomly divided into a control group and an observation group, 48 cases each. The control group received conventional symptomatic treatment, and the observation group received dexmedetomidine on the basis of the control group. The clinical renal function indicators [blood creatinine (Scr), urea nitrogen (BUN), serum cystatin C (Cys C), urine 24h creatinine clearance (24h Ccr)], and angiotensin Ⅱ (Ang Ⅱ) were compared between the two groups.Results After treatment, the Scr, BUN, and Cys C of the two groups were lower than before the treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05).After treatment, the 24h Ccr in the two groups was higher than before the treatment, and the observation group was higher than the control group, the difference was statistically significant (P<0.05).After treatment, AngⅡ was lower in both groups than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05).Conclusion Dexmedetomidine in the treatment of acute kidney injury in sepsis can effectively protect renal function, reduce the expression of AngⅡ, and further reduce the related damage caused by AngⅡ.

参考文献/References:

[1]高爽,郭树彬．脓毒症急性肾损伤的评价方法及临床意义[J].中国急救医学,2014(9):769-774. [2]陈燕,孟艳.人参二醇组皂苷改善内毒素诱导急性肾损伤小鼠肾功能的机制[J].中国老年学杂志,2014,34(10):2806-2809 [3]朱丹丹,于健,王之余.盲肠结扎穿孔术大鼠外周血内皮细胞微粒改变及意义[J].中华实验外科杂志,2016,33(3):614-617 [4]朴英花,朴兰.右美托咪定药理学特点及临床应用新进展[J].中国实用医药,2015,7(35):243-244. [5]周少丽,谭芳,陈裕洁.右美托咪啶用于治疗脓毒症的研究及其进展[J].实用医学杂志,2016,29(15):2421-2422.

相似文献/References:

[1]温占兵.血管生成素-1水平变化预测脓毒症急性肺损伤的价值[J].医学信息,2018,31(13):95.[doi:10.3969/j.issn.1006-1959.2018.13.027]
　WEN Zhan-bing.The Value of Angiopoietin-1 Level Change in Predicting Acute Lung Injury in Sepsis[J].Medical Information,2018,31(01):95.[doi:10.3969/j.issn.1006-1959.2018.13.027]
[2]吴 萌,王 平.右美托咪啶对老年重症肺炎有创机械通气患者镇静效果研究[J].医学信息,2018,31(16):118.[doi:10.3969/j.issn.1006-1959.2018.16.036]
　WU Meng,WANG Ping.Effect of Dexmedetomidine on Sedation in Elderly Patients with Severe Pneumonia Undergoing Invasive Mechanical Ventilation[J].Medical Information,2018,31(01):118.[doi:10.3969/j.issn.1006-1959.2018.16.036]
[3]文婷婷,杨懿琳,李秀泽.不同剂量右美托咪定联合七氟醚诱导在保留 自主呼吸气管插管中的对比研究[J].医学信息,2018,31(18):115.[doi:10.3969/j.issn.1006-1959.2018.18.036]
　WEN Ting-ting,YANG Yi-lin,LI Xiu-ze.Comparison of Different Doses of Dexmedetomidine Combined with Sevoflurane Induction in Tracheal Intubation with Spontaneous Breathing[J].Medical Information,2018,31(01):115.[doi:10.3969/j.issn.1006-1959.2018.18.036]
[4]申 贵,彭 翔,秦光梅.抗感染督导治疗对脓毒症患者预后影响的研究[J].医学信息,2019,32(01):82.[doi:10.3969/j.issn.1006-1959.2019.01.026]
　SHEN Gui,PENG Xiang,QIN Guang-mei.Study on the Effect of Anti-infective Supervision on the Prognosis of Patients with Sepsis[J].Medical Information,2019,32(01):82.[doi:10.3969/j.issn.1006-1959.2019.01.026]
[5]张恺悦,陈幼琼.乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究[J].医学信息,2019,32(04):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
　ZHANG Kai-yue,CHEN You-qiong.Effect of Ulinastatin Combined with Xuebijing on Coagulation Function and Systemic Inflammatory Response in Patients with Sepsis after Burn[J].Medical Information,2019,32(01):138.[doi:10.3969/j.issn.1006-1959.2019.04.044]
[6]张文旭,徐 绸.红细胞宽度对脓毒症患者病情诊断及预后评估的价值[J].医学信息,2022,35(14):71.[doi:10.3969/j.issn.1006-1959.2022.14.015]
　ZHANG Wen-xu,XU Chou.The Value of Red-blood-cell Distribution Width in the Diagnosis and Prognosis of Patients with Sepsis[J].Medical Information,2022,35(01):71.[doi:10.3969/j.issn.1006-1959.2022.14.015]
[7]朱思哲,叶成林.基于生物信息学分析构建免疫相关基因脓毒症预后模型[J].医学信息,2022,35(15):1.[doi:10.3969/j.issn.1006-1959.2022.15.001]
　ZHU Si-zhe,YE Cheng-lin.Identification of Immune-related Gene Prognostic Model for Sepsis Based on Bioinformatics Analysis[J].Medical Information,2022,35(01):1.[doi:10.3969/j.issn.1006-1959.2022.15.001]
[8]杨勋能.参苓白术散对脓毒症患者肠道功能的影响[J].医学信息,2019,32(16):146.[doi:10.3969/j.issn.1006-1959.2019.16.049]
　YANG Xun-neng.Effect of Shenling Baizhu Powder on Intestinal Function in Patients with Sepsis[J].Medical Information,2019,32(01):146.[doi:10.3969/j.issn.1006-1959.2019.16.049]
[9]杜金洁,胡 鹏.ESKAPE病原菌感染引起脓毒症的研究[J].医学信息,2019,32(21):33.[doi:10.3969/j.issn.1006-1959.2019.21.012]
　DU Jin-jie,HU Peng.Study on Sepsis Caused by ESKAPE Pathogen Infection[J].Medical Information,2019,32(01):33.[doi:10.3969/j.issn.1006-1959.2019.21.012]
[10]刘安平,段海真,汪 松.抗菌肽LL-37的生物学活性及其作用[J].医学信息,2019,32(24):13.[doi:10.3969/j.issn.1006-1959.2019.24.005]
　LIU An-ping,DUAN Hai-zhen,WANG Song.Biological Activity and Effect of Antibacterial Peptide LL-37[J].Medical Information,2019,32(01):13.[doi:10.3969/j.issn.1006-1959.2019.24.005]

更新日期/Last Update: 2020-01-01