[1]任雨欣.盐酸氨溴索联合二羟丙茶碱对煤工尘肺合并COPD的疗效[J].医学信息,2020,33(03):140-141.[doi:10.3969/j.issn.1006-1959.2020.03.044]
　REN Yu-xin.Efficacy of Ambroxol Hydrochloride Combined with Dihydroxyprophylline on Coal Workers’ Pneumoconiosis with COPD[J].Medical Information,2020,33(03):140-141.[doi:10.3969/j.issn.1006-1959.2020.03.044]
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盐酸氨溴索联合二羟丙茶碱对煤工尘肺合并COPD的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年03期
页码:
140-141
栏目:
药物与临床
出版日期:
2020-02-01

文章信息/Info

Title:
Efficacy of Ambroxol Hydrochloride Combined with Dihydroxyprophylline on Coal Workers’ Pneumoconiosis with COPD
文章编号:
1006-1959（2020）03-0140-02
作者:
任雨欣
（国家卫生健康委职业安全卫生研究中心呼吸科，北京 102300）
Author(s):
REN Yu-xin
(Department of Respiratory Medicine,Occupational Safety and Health Research Center,NationalHealth Commission,Beijing 102300,China)
关键词:
盐酸氨溴索; 二羟丙茶碱; 煤工尘肺合并COPD
Keywords:
Ambroxol hydrochloride; Dihydroxypropylphylline; Coal worker pneumoconiosis with COPD
分类号:
R135.2；R563
DOI:
10.3969/j.issn.1006-1959.2020.03.044
文献标志码:
A
摘要:
目的 探讨盐酸氨溴索联合二羟丙茶碱对煤工尘肺合并慢性阻塞性肺疾病（COPD）的疗效。方法 选取2018年6月~2019年6月于我院收治的86例煤工尘肺合并COPD患者为研究对象，根据治疗方式的不同将其分成研究组和对照组，各43例。对照组采用盐酸氨溴索治疗，研究组在对照组治疗的基础上加用二羟丙茶碱。比较两组临床疗效以及肺功能指标[第1秒用力呼气容积（FEV1）、第1秒呼气容积同肺活量（FVC）之间的比值（FEV1/FVC）、FEV1占预计值以及6 min步行试验（6 MWT）]。结果 研究组治疗总有效率为95.35%，高于对照组的83.72%，差异有统计学意义（P＜0.05）；治疗后研究组FEV1、FEV1/FVC、FEV1占预计值及6MWT均高于对照组，差异有统计学意义（P＜0.05）。结论 采用盐酸氨溴索结合二羟丙茶碱治疗煤工程肺合并COPD效果确切，有助于改善患者的肺功能指标。
Abstract:
Objective To investigate the effect of ambroxol hydrochloride combined with dihydroxyprophylline on coal workers’ pneumoconiosis with chronic obstructive pulmonary disease (COPD). Methods 86 patients with coal workers’ pneumoconiosis and COPD who were treated in our hospital from June 2018 to June 2019 were selected as study objects. They were divided into study group and control group according to different treatment methods, 43 cases each. The control group was treated with ambroxol hydrochloride, and the study group was treated with dihydroxypropphylline in addition to the treatment of the control group. Compare the clinical efficacy and pulmonary function indicators of the two groups [forced expiratory volume (FEV1) at 1 second, ratio of expiratory volume at 1 second to vital capacity (FVC) (FEV1/FVC), FEV1 accounting value, and 6min walking test. (6MWT)].Results The total effective rate of treatment in the study group was 95.35%, which was higher than 83.72% in the control group,the difference was statistically significant(P＜0.05). After treatment, the predicted values of FEV1,FEV1/FVC,FEV1 and 6MWT in the study group were higher than those in the control group,the difference was statistically significant(P＜0.05).Conclusion The effect of ambroxol hydrochloride combined with dihydroxypropphylline in treating coal-engined lung with COPD is definite, and it is helpful to improve the pulmonary function of patients.

参考文献/References:

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更新日期/Last Update: 2020-02-01