[1]赵 培.抗生素降阶梯方案治疗小儿重症肺炎的有效性与安全性分析[J].医学信息,2020,33(03):146-147.[doi:10.3969/j.issn.1006-1959.2020.03.047]
　ZHAO Pei.Effect of Antibiotic Step-down Protocol on Children with Severe Pneumonia[J].Medical Information,2020,33(03):146-147.[doi:10.3969/j.issn.1006-1959.2020.03.047]
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抗生素降阶梯方案治疗小儿重症肺炎的有效性与安全性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年03期
页码:
146-147
栏目:
药物与临床
出版日期:
2020-02-01

文章信息/Info

Title:
Effect of Antibiotic Step-down Protocol on Children with Severe Pneumonia
文章编号:
1006-1959（2020）03-0146-02
作者:
赵 培
（天津市津南医院药剂科，天津 300350）
Author(s):
ZHAO Pei
(Department of Pharmacy,Tianjin Jinnan Hospital,Tianjin 300350,China)
关键词:
抗生素; 降阶梯方案; 重症肺炎; 不良反应
Keywords:
Antibiotics; Step-down protocol; Severe pneumonia; Adverse reactions
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2020.03.047
文献标志码:
A
摘要:
目的 探讨抗生素降阶梯方案治疗小儿重症肺炎的有效性与安全性。方法 选取2018年7月~2019年7月于我院接受治疗的重症肺炎患儿1002例，随机分为研究组（500例）和对照组（502例），对照组行常规抗生素治疗，研究组行抗生素降阶梯方案治疗，比较两组临床疗效、感染控制时间、抗生素使用时间、住院时间及不良反应发生情况。结果 研究组治疗总有效率为99.00%，高于对照组的97.01%，差异有统计学意义（P＜0.05）；研究组感染控制时间、抗生素使用时间及住院时间均短于对照组，差异有统计学意义（P＜0.05）；研究组不良反应发生率低于对照组（1.00% vs 3.59%），差异有统计学意义（P＜0.05）。结论 抗生素降阶梯方案治疗小儿重症肺炎效果显著，可有效控制患儿感染，遏制病情发展，减少住院时间，不良反应少，安全性高。
Abstract:
Objective To explore the effectiveness and safety of antibiotic step-down protocol in treating children with severe pneumonia. Methods 1002 children with severe pneumonia who were treated in our hospital from July 2018 to July 2019 were randomly divided into a study group (500 cases) and a control group (502 cases). The control group received conventional antibiotic treatment and the study group The patients were treated with antibiotic step-down protocol, and the clinical efficacy, infection control time, antibiotic use time, hospital stay and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 99.00%, which was higher than 97.01% in the control group,the differences were statistically significant (P<0.05). The infection control time, antibiotic use time, and hospital stay in the study group were shorter than those in the control group,the differences were statistically significant(P<0.05); the incidence of adverse reactions in the study group was lower than that in the control group (1.00% vs 3.59%),the difference was statistically significant (P<0.05).Conclusion The antibiotic step-down protocol has a significant effect in treating children with severe pneumonia. It can effectively control the infection of children, curb the development of the disease, reduce the length of hospitalization, less adverse reactions, and high safety.

参考文献/References:

[1]陈昭燕,占美,田方圆,等.抗生素降阶梯方案治疗小儿重症肺炎有效性及安全性的Meta分析[J].中国抗生素杂志,2017, 12(42):1076. [2]尹维红.抗生素降阶梯治疗小儿重症肺炎疗效观察探讨[J].中国医药导刊,2017,19(2):163-164. [3]张培金,闵琦芬,刘协萍,等.抗菌药物降阶梯疗法对肺炎患者临床结局影响的Meta分析[J].中华医院感染学杂志,2017, 12(12):234-235. [4]樊婷.细菌性重症肺炎患儿继发抗生素相关性腹泻的危险因素分析[J].实用心脑肺血管病杂志,2018,26(3):141-143. [5]王利,朱波,何小鹏.肺部感染评分对重症肺炎患者抗生素的指导及对预后的影响[J].临床肺科杂志,2017,33(10):113-116.

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更新日期/Last Update: 2020-02-01