[1]吴冬梅,王凤琴,姚文娟,等.高危型HPV分型检测联合TCT检查在宫颈病变筛查中的意义[J].医学信息,2020,33(04):173-174.[doi:10.3969/j.issn.1006-1959.2020.04.058]
　WU Dong-mei,WANG Feng-qin,YAO Wen-juan,et al.Significance of High-risk HPV Typing and TCT in Cervical Lesion Screening[J].Medical Information,2020,33(04):173-174.[doi:10.3969/j.issn.1006-1959.2020.04.058]
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高危型HPV分型检测联合TCT检查在宫颈病变筛查中的意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年04期
页码:
173-174
栏目:
诊疗技术
出版日期:
2020-02-15

文章信息/Info

Title:
Significance of High-risk HPV Typing and TCT in Cervical Lesion Screening
文章编号:
1006-1959（2020）04-0173-02
作者:
吴冬梅; 王凤琴; 姚文娟; 等
（河北中石油中心医院病理科，河北 廊坊 065000）
Author(s):
WU Dong-mei; WANG Feng-qin; YAO Wen-juan; et al
(Department of Pathology,Hebei PetroChina Central Hospital,Langfang 065000,Hebei,China)
关键词:
人乳头状瘤病毒; 薄层液基细胞学; 宫颈病变; 病理学诊断
Keywords:
High-risk human papilloma virus; Thin-layer liquid-based cytology; Cervical lesions; Pathological diagnosis
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2020.04.058
文献标志码:
A
摘要:
目的 探讨高危型人乳头状瘤病毒（HR-HPV）分型检测联合薄层液基细胞学检查（TCT）在宫颈病变筛查中的应用价值。方法 选取2017年3月~2018年3月我院收治的宫颈病变患者416例为研究对象，均行HR-HPV分型检测、TCT检查以及阴道镜病理活检，以组织病理学检查结果为“金标准”，比较HR-HPV分型检测与TCT检查对宫颈癌的诊断价值。结果 416例患者中病理诊断为炎症的213例，CINⅠ102例、CINⅡ69例、CINⅢ25例，鳞状细胞癌7例。联合检测的敏感性、特异性、诊断符合率分别98.52%、100.00%、99.28%分别高于TCT检查的79.80%、84.51%、82.21%以及HR-HPV检测的89.66%、63.38%、76.20%，差异有统计学意义（P＜0.05）。结论 HR-HPV分型联合TCT检测能够提高宫颈病变的检出率，降低漏诊率，对宫颈癌的防治具有重要意义。
Abstract:
Objective To investigate the application value of high-risk human papilloma virus (HR-HPV) typing and thin-layer liquid-based cytology (TCT) in screening for cervical lesions.Methods A total of 416 patients with cervical lesions admitted in our hospital from March 2017 to March 2018 were selected as the research subjects.All patients underwent HR-HPV typing,TCT and colposcopy pathological biopsy.The results of histopathological examination were"gold standard"to compare the diagnostic value of HR-HPV typing test and TCT test for cervical cancer.Results Among 416 patients,213 were pathologically diagnosed as inflammation, 102 were CINⅠ,69 were CINⅡ,25 were CINⅢ,and 7 were squamous cell carcinoma.The sensitivity,specificity,and diagnostic coincidence rates of the combined tests were 98.52%,100.00%,and 99.28%,respectively,which was higher than 79.80%,84.51%,82.21% of TCT test and 89.66%,63.38%,76.20% of HR-HPV test,the difference was statistically significant(P＜0.05).Conclusion HR-HPV classification combined with TCT detection can improve the detection rate of cervical lesions and reduce the rate of missed diagnosis,which is of great significance for the prevention and treatment of cervical cancer.

参考文献/References:

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更新日期/Last Update: 2020-02-15