[1]向青林,张 伟.HER2、EGFR、VEGFR在胃印戒细胞癌中的表达及其临床意义[J].医学信息,2020,33(06):87-89.[doi:10.3969/j.issn.1006-1959.2020.06.025]
　XIANG Qing-lin,ZHANG Wei.Expression of HER2,EGFR and VEGFR in Gastric Signet Ring Cell Carcinoma and Its Clinical Significance[J].Medical Information,2020,33(06):87-89.[doi:10.3969/j.issn.1006-1959.2020.06.025]
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HER2、EGFR、VEGFR在胃印戒细胞癌中的表达及其临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年06期
页码:
87-89
栏目:
论著
出版日期:
2020-03-15

文章信息/Info

Title:
Expression of HER2,EGFR and VEGFR in Gastric Signet Ring Cell Carcinoma and Its Clinical Significance
文章编号:
1006-1959（2020）06-0087-03
作者:
向青林; 张 伟
（重庆医科大学附属第一医院胃肠外科，重庆 400010）
Author(s):
XIANG Qing-lin; ZHANG Wei
(Department of Gastroenterology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
关键词:
胃印戒细胞癌; EGFR; VEGF; HER2
Keywords:
Gastric signet ring cell carcinoma; EGFR; VEGF; HER2
分类号:
R735.2
DOI:
10.3969/j.issn.1006-1959.2020.06.025
文献标志码:
A
摘要:
目的 探讨HER2、EGFR、VEGFR在胃印戒细胞癌中的表达及其临床意义。方法 选取我院2013年 4月~2018年3月胃印戒细胞癌组织55例，检测中的人类表皮生长因子受体2（HER2）、表皮生长因子受体（EGFR）和血管内皮生长因子（VEGF-R）表达并分析其与胃印戒细胞癌临床特征的关系。结果 胃印戒细胞癌组织中HER2、EGFR、VEGFR的表达率分别为43.64%（24/55）、38.18%（21/55）和38.18%（21/55）。相关性分析显示，HER2、EGFR、VEGFR表达与浸润深度、淋巴结转移及TNM分期有关（P＜0.05），与性别、年龄无关（P＞0.05）；HER2、EGFR、VEGFR三者存在共表达现象，表达强度呈正相关。结论 胃印戒细胞癌组织中HER2、EGFR、VEGFR表达水平与胃印戒细胞癌组织恶性程度密切相关，通过对HER2、EGFR、VEGFR三者表达水平的检测可能有助于降低胃印戒细胞癌术前的误诊率、为靶向HER2、EGFR、VEGFR生物治疗制剂在胃印戒细胞癌生物治疗中的应用及联合应用提供了一定的理论依据。
Abstract:
Objective To investigate the expression of HER2, EGFR and VEGFR in gastric signet ring cell carcinoma and its clinical significance. Methods 55 cases of gastric signet ring cell carcinoma tissues from April 2013 to March 2018 in our hospital were selected. The expressions of human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF-R) in the test were analyzed and their relationship with clinical features of gastric signet ring cell carcinoma was analyzed. Results The expression rates of HER2, EGFR, and VEGFR in gastric signet ring cell carcinoma tissues were 43.64% (24/55), 38.18% (21/55), and 38.18% (21/55). Correlation analysis showed that the expressions of HER2, EGFR, and VEGFR were related to the depth of invasion, lymph node metastasis, and TNM stage (P<0.05), and were not related to gender and age (P>0.05);co-expression of HER2, EGFR, and VEGFR existed, and the expression intensity was positively correlated.Conclusion The expression levels of HER2, EGFR, and VEGFR in gastric signet ring cell carcinoma tissues are closely related to the malignant degree of gastric signet ring cell carcinoma tissues. Detection of the expression levels of HER2, EGFR, and VEGFR may help reduce gastric signet ring cell carcinoma. The preoperative misdiagnosis rate provided a certain theoretical basis for the application and combination of targeted HER2, EGFR, and VEGFR biotherapeutics in the biological treatment of signet ring cell carcinoma.

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更新日期/Last Update: 2020-03-15