[1]陈小军.布地奈德联合噻托溴铵治疗哮喘-慢阻肺重叠综合征的疗效[J].医学信息,2020,33(06):154-155.[doi:10.3969/j.issn.1006-1959.2020.06.051]
 CHEN Xiao-jun.Efficacy of Budesonide Combined with Tiotropium Bromide in the Treatment of Asthma-COPD Overlap Syndrome[J].Medical Information,2020,33(06):154-155.[doi:10.3969/j.issn.1006-1959.2020.06.051]
点击复制

布地奈德联合噻托溴铵治疗哮喘-慢阻肺重叠综合征的疗效()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年06期
页码:
154-155
栏目:
药物与临床
出版日期:
2020-03-15

文章信息/Info

Title:
Efficacy of Budesonide Combined with Tiotropium Bromide in the Treatment of Asthma-COPD Overlap Syndrome
文章编号:
1006-1959(2020)06-0154-02
作者:
陈小军
(江西省吉水县中医院呼吸内科,江西 吉水 343000)
Author(s):
CHEN Xiao-jun
(Department of Respiratory Medicine,Jishui County Traditional Chinese Medicine Hospital,Jishui 343000,Jiangxi,China)
关键词:
糖皮质激素布地奈德噻托溴铵哮喘-慢阻肺重叠综合征
Keywords:
GlucocorticoidBudesonideTiotropium bromideAsthma-COPD overlap syndrome
分类号:
R563;
DOI:
10.3969/j.issn.1006-1959.2020.06.051
文献标志码:
A
摘要:
目的 观察哮喘-慢阻肺重叠综合征应用布地奈德联合噻托溴铵治疗效果。方法 选取2017年1月~2019年6月在江西省吉水县中医院诊治的48例哮喘-慢阻肺重叠综合征患者为研究对象,采用随机数字表法分为观察组和对照组,各24例。对照组给予吸入用布地奈德治疗,观察组在此基础上联合噻托溴铵治疗,比较两组治疗总有效率、哮喘症状和慢阻肺症状评分、肺功能指标[1秒用力呼气量(FEV1)、最大肺活量(FVC)]及不良反应发生率。结果 观察组治疗总有效率为91.67%,高于对照组的79.16%(P<0.05);治疗后两组哮喘症状评分、慢阻肺症状评分均低于治疗前,且观察组低于对照组(P<0.05);治疗后两组FEV1、FVC均高于治疗前,且观察组高于对照组(P<0.05);观察组不良反应发生率为4.16%,与对照组的8.33%比较,差异无统计学意义(P>0.05)。结论 布地奈德联合噻托溴铵治疗哮喘-慢阻肺重叠综合征效果确切,有助于改善患者肺功能,减轻临床症状,且临床不良反应少。
Abstract:
Objective To observe the effect of budesonide combined with tiotropium bromide in the treatment of asthma-COPD overlap syndrome. Methods 48 patients with asthma-chronic obstructive pulmonary disease syndrome who were treated at Jishui County Traditional Chinese Medicine Hospital,Jiangxi Province from January 2017 to June 2019 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 24 cases in each group. The control group was treated with inhaled budesonide, and the observation group was combined with tiotropium bromide on this basis. The two groups were compared for total effective rate, asthma symptoms and COPD scores, pulmonary function indicators [forced expiratory volume in 1 second (FEV1), maximum vital capacity (FVC)], and incidence of adverse reactions. Results The total effective rate of treatment in the observation group was 91.67%, which was higher than 79.16% in the control group(P<0.05). After treatment, the scores of asthma symptoms and COPD in the two groups were lower than before treatment. The group was lower than the control group (P<0.05); after treatment, the FEV1 and FVC were higher in both groups than before the treatment, and the observation group was higher than the control group (P<0.05); The incidence of adverse reactions in the group was 4.16%, compared with 8.33% in the control group, the difference was not statistically significant (P>0.05).Conclusion Budesonide combined with tiotropium bromide is effective in the treatment of asthma-coronary obstructive pulmonary overlap syndrome, and it can help to improve lung function, reduce clinical symptoms, and have fewer clinical adverse reactions.

参考文献/References:

[1]李永锋,许志强,韩鹏,等.哮喘-慢阻肺重叠综合征临床特征及防治措施探讨[J].河南医学研究,2016,25(8):1480-1481.[2]张卓红.吸入激素对哮喘-慢阻肺重叠综合征患者气道重塑及内皮细胞功能的影响[J].陕西医学杂志,2016,45(8):1040-1042.[3]田攀文,文富强.雾化吸入糖皮质激素治疗慢性阻塞性肺疾病急性加重期的疗效和安全性[J].中华结核和呼吸杂志,2015,38(2):89-92.[4]刘凌云.哮喘-慢阻肺重叠综合征患者呼出气一氧化氮与诱导痰嗜酸粒细胞及肺功能的相关性研究[J].岭南急诊医学杂志,2016,21(3):226-227,232.[5]欧阳可.慢阻肺急性加重期采用糖皮质激素联合特布他林治疗的临床体会[J].医学信息,2014,15(23):614-615.

相似文献/References:

[1]钟时嘉.亚急性甲状腺炎的临床分析[J].医学信息,2018,31(01):181.[doi:10.3969/j.issn.1006-1959.2018.01.073]
 ZHONG Shi-jia.Clinical Analysis of Subacute Thyroiditis[J].Medical Information,2018,31(06):181.[doi:10.3969/j.issn.1006-1959.2018.01.073]
[2]唐培渊,宋俊峰,秦克乐,等.难治性特发性血小板减少性紫癜的治疗进展[J].医学信息,2018,31(05):42.[doi:10.3969/j.issn.1006-1959.2018.05.016]
 TANG Pei-yuan,SONG Jun-feng,QIN Ke-le,et al.Progress in Treatment of Refractory Idiopathic Thrombocytopenic Purpura[J].Medical Information,2018,31(06):42.[doi:10.3969/j.issn.1006-1959.2018.05.016]
[3]苗艳茹.甲巯咪唑与糖皮质激素联合治疗甲状腺功能亢进症合并症的效果分析[J].医学信息,2018,31(05):136.[doi:10.3969/j.issn.1006-1959.2018.05.048]
 MIAO Yan-ru.Analysis of Effects of Methimazole and Glucocorticoids on Complications of Hyperthyroidism[J].Medical Information,2018,31(06):136.[doi:10.3969/j.issn.1006-1959.2018.05.048]
[4]马建娟.布地奈德联合异丙托溴铵雾化治疗COPD 急性加重期的效果评价[J].医学信息,2018,31(07):141.[doi:10.3969/j.issn.1006-1959.2018.07.048]
 MA Jian-juan.Efficacy Evaluation of Budesonide Combined with Ipratropium Bromide in Treatment of Acute Exacerbation of COPD[J].Medical Information,2018,31(06):141.[doi:10.3969/j.issn.1006-1959.2018.07.048]
[5]康 凯,郑继伟,王 闰.糖皮质激素治疗甲亢伴浸润性突眼的疗效分析[J].医学信息,2018,31(08):103.[doi:10.3969/j.issn.1006-1959.2018.08.033]
 KANG Kai,ZHENG Ji-wei,WANG Run.Efficacy of Glucocorticoids in the Treatment of Hyperthyroidism with Infiltrating Exophthalmos[J].Medical Information,2018,31(06):103.[doi:10.3969/j.issn.1006-1959.2018.08.033]
[6]罗玉霞.舒适护理在布地奈德联合氨溴索雾化吸入治疗 慢阻肺急性发作患者的效果分析[J].医学信息,2018,31(12):179.[doi:10.3969/j.issn.1006-1959.2018.12.058]
 LUO Yu-xia.Analysis of the Effect of Comfortable Nursing in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients with Aerosolized Inhalation of Budesonide and Ambroxol[J].Medical Information,2018,31(06):179.[doi:10.3969/j.issn.1006-1959.2018.12.058]
[7]张明荣.孟鲁司特钠联合布地奈德治疗小儿哮喘的临床疗效分析[J].医学信息,2018,31(13):131.[doi:10.3969/j.issn.1006-1959.2018.13.038]
 ZHANG Ming-rong.Clinical Analysis of Montelukast Sodium Combined with Budesonide in the Treatment of Childhood Asthma[J].Medical Information,2018,31(06):131.[doi:10.3969/j.issn.1006-1959.2018.13.038]
[8]赵 维,廖荣宏,王爱华.糖皮质激素治疗心力衰竭疗效与安全性的Meta分析[J].医学信息,2018,31(14):70.[doi:10.3969/j.issn.1006-1959.2018.14.021]
 ZHAO Wei,LIAO Rong-hong,WANG Ai-hua.Meta-analysis of the Efficacy and Safety of Glucocorticoids in the Treatment of Heart Failure[J].Medical Information,2018,31(06):70.[doi:10.3969/j.issn.1006-1959.2018.14.021]
[9]曾穗茹,王蓉梅.孟鲁司特联合布地奈德雾化吸入用于肺炎支原体感染后慢性咳嗽患儿的效果观察[J].医学信息,2018,31(19):137.[doi:10.3969/j.issn.1006-1959.2018.19.041]
 ZENG Sui-ru,WANG Rong-mei.Efficacy of Montelukast Combined with Budesonide Aerosol Inhalation in Children with Chronic Cough after Mycoplasma Pneumoniae Infection[J].Medical Information,2018,31(06):137.[doi:10.3969/j.issn.1006-1959.2018.19.041]
[10]刘广涛,关凤军,董 晨.原发性肾病综合征患儿肾组织P-gp170蛋白和mRNA表达与临床病理及预后的关系[J].医学信息,2018,31(21):61.[doi:10.3969/j.issn.1006-1959.2018.21.017]
 LIU Guang-tao,GUAN Feng-jun,DONG Chen.Relationship between the Expression of p-gp170 Protein and mRNA in Renal Tissue of Children with Primary Nephrotic Syndrome and Clinical Pathology and Prognosis[J].Medical Information,2018,31(06):61.[doi:10.3969/j.issn.1006-1959.2018.21.017]

更新日期/Last Update: 2020-03-15