[1]谭晓瑜,黄金智,赖锦胜,等.SP/NK-1R及其与子宫内膜癌的关系[J].医学信息,2020,33(07):29-32.[doi:10.3969/j.issn.1006-1959.2020.07.010]
 TAN Xiao-yu,HUANG Jin-zhi,LAI Jin-sheng,et al.Study on SP/NK-1R and Its Relationship with Endometrial Cancer[J].Medical Information,2020,33(07):29-32.[doi:10.3969/j.issn.1006-1959.2020.07.010]
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SP/NK-1R及其与子宫内膜癌的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年07期
页码:
29-32
栏目:
综述
出版日期:
2020-04-01

文章信息/Info

Title:
Study on SP/NK-1R and Its Relationship with Endometrial Cancer
文章编号:
1006-1959(2020)07-0029-04
作者:
谭晓瑜黄金智赖锦胜
(1.广东医科大学,广东 湛江 524001;2.广东医科大学附属医院妇产科,广东 湛江 524002)
Author(s):
TAN Xiao-yuHUANG Jin-zhiLAI Jin-shenget al
(1.Guangdong Medical University,Zhanjiang 524001,Guangdong,China;2.Department of Obstetrics and Gynecology,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524002,Guangdong,China)
关键词:
SP/NK-1R肿瘤功能子宫内膜癌
Keywords:
SP/NK-1RTumor functionEndometrial cancer
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2020.07.010
文献标志码:
A
摘要:
随着分子生物学和免疫学的发展,源自中枢组织的P物质(SP)因其广泛分布于人体各个组织而成为研究的热点。SP主要通过与其特异性受体神经激肽1受体(NK-1)结合而具有多种生物学活性,比如诱导炎症环境,促进肿瘤细胞的神经向性,诱导肿瘤细胞的增殖、迁移及促进胰岛素抵抗,上述机制与子宫内膜癌的发病及预后关系密切,可作为临床诊治子宫内膜癌的一个新靶点。因此,本文就该因子的生物学功能、在肿瘤方面的作用及其与子宫内膜癌的关系进行综述。
Abstract:
With the development of molecular biology and immunology, substance P(SP)derived from central tissues has become a research focus due to its widespread distribution in various human tissues.SP mainly has a variety of biological activities by binding to its specific receptor neurokinin 1 receptor(NK-1),such as inducing an inflammatory environment,promoting the neurotropy of tumor cells,inducing the proliferation, migration and promotion of tumor cells Insulin resistance,the above mechanism is closely related to the incidence and prognosis of endometrial cancer,and may become a new target for clinical diagnosis and treatment of endometrial cancer.This article reviews the biological function of the factor,its role in tumors,and its relationship with endometrial cancer.

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更新日期/Last Update: 2020-04-01