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The Role of SDF-1/CXCR4/CXCR7 Signal Axis in Ischemic Stroke
吴 滢
(上海中医药大学附属上海市中西医结合医院神经内科,上海 200082)
WU Ying
(Department of Neurology,Shanghai Integrated Traditional Chinese and Western Medicine Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China)
Stromal cell-derived factor-1Ischemic strokeCXCR4CXCR7
Stromal cell-derived factor-1 (SDF-1) is a CXC-like chemotactic protein produced by bone marrow stromal cells. CXCR4 and CXCR7 are two known G protein-coupled receptors activated by SDF-1, which are both expressed in the developing and mature central nervous system and participate in various pathophysiological processes in the central nervous system, including the brain Development, angiogenesis, neurodegeneration and neurogenesis. After cerebral ischemic injury, the level of SDF-1 in the ischemic penumbra significantly increased and induced neurological function repair. The SDF-1 / CXCR4 / CXCR7 signaling pathway may provide a new target for the treatment of stroke. This article mainly reviews the structure of SDF-1 / CXCR4 / CXCR7, its expression and interaction in the central nervous system, and its role in cerebral ischemia, aiming to provide a theoretical reference for the treatment of ischemic stroke.


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更新日期/Last Update: 1900-01-01