[1]吴 滢.SDF-1/CXCR4/CXCR7信号轴在缺血性脑卒中中的作用[J].医学信息,2020,(11):34-37.[doi:10.3969/j.issn.1006-1959.2020.11.012]
 WU Ying.The Role of SDF-1/CXCR4/CXCR7 Signal Axis in Ischemic Stroke[J].Medical Information,2020,(11):34-37.[doi:10.3969/j.issn.1006-1959.2020.11.012]
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SDF-1/CXCR4/CXCR7信号轴在缺血性脑卒中中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2020年11期
页码:
34-37
栏目:
综述
出版日期:
2020-06-01

文章信息/Info

Title:
The Role of SDF-1/CXCR4/CXCR7 Signal Axis in Ischemic Stroke
文章编号:
1006-1959(2020)11-0034-04
作者:
吴 滢
(上海中医药大学附属上海市中西医结合医院神经内科,上海 200082)
Author(s):
WU Ying
(Department of Neurology,Shanghai Integrated Traditional Chinese and Western Medicine Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China)
关键词:
基质细胞衍生因子-1缺血性卒中CXCR4CXCR7
Keywords:
Stromal cell-derived factor-1Ischemic strokeCXCR4CXCR7
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2020.11.012
文献标志码:
A
摘要:
基质细胞衍生因子-1(SDF-1)是由骨髓基质细胞产生的CXC类趋化蛋白。CXCR4和CXCR7是已知的两个由SDF-1激活的两个G蛋白偶联受体,在发育和成熟的中枢神经系统中均表达,并参与中枢神经系统中多种病理生理过程,包括脑发育、血管生成、神经变性和神经发生。脑缺血性损伤后,缺血半暗带内SDF-1水平显着增加并诱导神经功能修复,SDF-1/CXCR4/CXCR7信号传导通路可能为卒中的治疗提供新的靶点。本文主要就SDF-1/CXCR4/CXCR7的结构、在中枢神经系统中的表达、相互作用以及其在脑缺血中的作用进行综述,旨在为缺血性脑卒中的治疗提供理论参考。
Abstract:
Stromal cell-derived factor-1 (SDF-1) is a CXC-like chemotactic protein produced by bone marrow stromal cells. CXCR4 and CXCR7 are two known G protein-coupled receptors activated by SDF-1, which are both expressed in the developing and mature central nervous system and participate in various pathophysiological processes in the central nervous system, including the brain Development, angiogenesis, neurodegeneration and neurogenesis. After cerebral ischemic injury, the level of SDF-1 in the ischemic penumbra significantly increased and induced neurological function repair. The SDF-1 / CXCR4 / CXCR7 signaling pathway may provide a new target for the treatment of stroke. This article mainly reviews the structure of SDF-1 / CXCR4 / CXCR7, its expression and interaction in the central nervous system, and its role in cerebral ischemia, aiming to provide a theoretical reference for the treatment of ischemic stroke.

参考文献/References:

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更新日期/Last Update: 1900-01-01